Abstract:
:At the end of the last century, microarray technology that examines the total genes and transcripts present in a cell became available as a laboratory tool. Mast cells are known to play a pivotal role in initiating allergic inflammation by releasing various mediators and cytokines. According to the recent microarray-based studies, mast cells have been found to be much more versatile functional molecules than we ever thought. Also, genes that are exclusively expressed in mast cells have been identified in comparison with other cell types. In this article, the outcome of microarray-based analyses on the role of mast cells in allergic inflammation will be reviewed by focusing on the mast cell-specific genes as drug targets.
journal_name
J Pharmacol Scijournal_title
Journal of pharmacological sciencesauthors
Saito Hdoi
10.1254/jphs.fm0070192subject
Has Abstractpub_date
2008-03-01 00:00:00pages
341-6issue
3eissn
1347-8613issn
1347-8648pii
JST.JSTAGE/jphs/FM0070192journal_volume
106pub_type
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