当前位置： SCI文献检索 > JOURNAL OF PHARMACOLOGICAL SCIENCES期刊下所有文献 > Effects of melittin on the production of matrix metalloproteinase-1 and -3 in rheumatoid arthritic fibroblast-like synoviocytes.

Effects of melittin on the production of matrix metalloproteinase-1 and -3 in rheumatoid arthritic fibroblast-like synoviocytes.

Abstract：

:Bee venom (BV) has been used in patients with rheumatoid arthritis, a condition characterized by rheumatoid joint destruction mediated, in large part, by matrix metalloproteinases (MMPs). We investigated the effects of melittin, a major component of bee venom, on the production of MMPs in human rheumatoid arthritic fibroblast-like synoviocytes (FLS). Lipopolysaccharide (LPS)-stimulated MMP3 production was significantly inhibited by melittin, which also inhibited LPS-induced DNA binding by nuclear factor kappaB (NF-kappaB). Mellitin had no effect on IL-1beta- or TNF-alpha-induced MMP1 or MMP3 production and did not decrease LPS-induced secretion of MMP1. Taken together, these findings suggest that melittin may exert its anti-rheumatoid effects, at least in part, by inhibiting MMP3 production, most likely through inhibition of NF-kappaB activity.

journal_name

J Pharmacol Sci

journal_title

Journal of pharmacological sciences

authors

Nah SS,Ha E,Mun SH,Won HJ,Chung JH

doi

10.1254/jphs.sc0070215

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

162-6

issue

1

eissn

1347-8613

issn

1347-8648

pii

JST.JSTAGE/jphs/SC0070215

journal_volume

106

pub_type

杂志文章

相关文献

JOURNAL OF PHARMACOLOGICAL SCIENCES文献大全
  • Antidepressant-like effect of venlafaxine is abolished in μ-opioid receptor-knockout mice.

    abstract：:Although the opioid system is known to modulate depression-like behaviors, its role in the effects of antidepressants is not yet clear. We investigated the role of μ-opioid receptors (MOPs) in the effects of venlafaxine, a serotonin and norepinephrine reuptake inhibitor, in the forced swim test using MOP-knockout (KO)...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.10136sc

    authors： Ide S,Fujiwara S,Fujiwara M,Sora I,Ikeda K,Minami M,Uhl GR,Ishihara K

    更新日期：2010-01-01 00:00:00

  • Na+, K+-ATPase inhibition induces neuronal cell death in rat hippocampal slice cultures: Association with GLAST and glial cell abnormalities.

    abstract：:Na+, K+-ATPase is a highly expressed membrane protein. Dysfunction of Na+, K+-ATPase has been implicated in the pathophysiology of several neurodegenerative and psychiatric disorders, however, the underlying mechanism of neuronal cell death resulting from Na+, K+-ATPase dysfunction is poorly understood. Here, we inves...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2018.09.004

    authors： Kurauchi Y,Noma K,Hisatsune A,Seki T,Katsuki H

    更新日期：2018-11-01 00:00:00

  • A simple method using anesthetics to test effects of sleep-inducing substances in mice.

    abstract：:We investigated the effects of sleep-inducing agents with different mechanisms of action on the loss of the righting reflex induced by isoflurane or a mixture of medetomidine, midazolam, and butorphanol (MMB), followed by atipamezole reversal. Chlorpromazine and brotizolam delayed recovery from both types of anesthesi...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2019.12.003

    authors： Murai H,Suzuki H,Tanji H,Kimura T,Iba Y

    更新日期：2020-02-01 00:00:00

  • The selective metabotropic glutamate 2/3 receptor agonist MGS0028 reverses isolation rearing-induced abnormal behaviors in mice.

    abstract：:Isolation-induced abnormal behaviors are useful animal models for assessing potential anti-psychotic drugs. This study examined the effect of MGS0028, a selective metabotropic glutamate 2/3 receptor agonist, on abnormal behaviors such as hyperactivity, aggression, and deficits of prepulse inhibition in isolation-reare...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.11200sc

    authors： Ago Y,Araki R,Yano K,Kawasaki T,Chaki S,Nakazato A,Onoe H,Hashimoto H,Baba A,Takuma K,Matsuda T

    更新日期：2012-01-01 00:00:00

  • Bladder Contractility Is Mediated by Different K+ Channels in the Urothelium and Detrusor Smooth Muscle.

    abstract：:The roles played by K+ channels in the urothelium (UE) and detrusor smooth muscle (DSM) in regulating agonist-induced bladder contraction is not known at present. Thus, the effects in carbachol (CCh)-induced contraction in UE-intact (+UE) and UE-denuded (-UE) rat detrusor strips pretreated with K+-channel blockers wer...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.10162FP

    authors： Hidayat Santoso AG,Liang W

    更新日期：2011-01-01 00:00:00

  • Pathophysiological significance of T-type Ca2+ channels: expression of T-type Ca2+ channels in fetal and diseased heart.

    abstract：:Re-expression of fetal genes has been considered to underlie ionic remodeling in diseased heart. T-type Ca(2+) channels have been reported to be functionally expressed in embryonic hearts. In this review, we summarize developmental changes of T-type Ca(2+) channels in mouse ventricles from 9.5 days postcoitum (dpc) to...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章,评审

    doi：10.1254/jphs.fmj05002x3

    authors： Yasui K,Niwa N,Takemura H,Opthof T,Muto T,Horiba M,Shimizu A,Lee JK,Honjo H,Kamiya K,Kodama I

    更新日期：2005-11-01 00:00:00

  • TRPV4-like non-selective cation currents in cultured aortic myocytes.

    abstract：:In this study, we provide evidence of critical changes in the expression of non-selective cation currents (NSCC) during culture in rat aortic myocytes. A selective TRPV4 agonist, 4alpha-phorbol 12,13-didecanoate (4alphaPDD), had little effect on membrane currents and intracellular Ca(2+) (Ca(2+)(i)) in freshly isolate...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.08133fp

    authors： Tanaka R,Muraki K,Ohya S,Yamamura H,Hatano N,Itoh Y,Imaizumi Y

    更新日期：2008-10-01 00:00:00

  • A perspective on metabolic surgery from a gastroenterologist.

    abstract：:Type 2 diabetes (T2D) and obesity are important public health problems. The global prevalence of diabetes mellitus is 8.8%. Interventional diabetology and obesitology have been recently advocated as treatment options for T2D and obesity. The roles of metabolic surgery such as Roux-en-Y gastric bypass, sleeve gastrecto...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.jphs.2017.01.001

    authors： Syu YF,Inui A,Chen CY

    更新日期：2017-02-01 00:00:00

  • Basic and translational research on proteinase-activated receptors: antagonism of the proteinase-activated receptor 1 for thrombin, a novel approach to antiplatelet therapy for atherothrombotic disease.

    abstract：:Atherothrombotic disease is a leading public health problem. Although current antiplatelet agents, such as aspirin and adenosine diphosphate (ADP)-receptor antagonists, reduce the morbidity and mortality associated with atherothrombotic disease, the residual risk for ischemic events remains substantial. The high resid...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.08r06fm

    authors： Chintala M,Shimizu K,Ogawa M,Yamaguchi H,Doi M,Jensen P

    更新日期：2008-12-01 00:00:00

  • Nitric oxide plays a critical role in methotrexate-induced hyperplasia of enterochromaffin cells containing 5-hydroxytryptamine in rat small intestine.

    abstract：:The role of nitric oxide (NO) in the changes in enterochromaffin cells and ileal 5-hydroxytryptamine (5-HT) content induced by a single i.p. administration of methotrexate was investigated in rats. Methotrexate significantly increased inducible NO synthase (iNOS) mRNA and protein expressions in the intestinal tissue a...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2019.09.001

    authors： Takano Y,Hirano M,Machida T,Obara Y,Hamaue N,Fujita K,Taniguchi M,Endo T,Shiga S,Machida M,Iizuka K,Hirafuji M

    更新日期：2019-09-01 00:00:00

  • Cyclic ADP-ribose mediates formyl methionyl leucyl phenylalanine (fMLP)-induced intracellular Ca(2+) rise and migration of human neutrophils.

    abstract：:Although cyclic ADP-ribose (cADPR), a novel Ca(2+)-mobilizing mediator, is suggested to be involved in the functions of neutrophils in rodents, its role in human neutrophils remains unclear. The present study examined the ability of cADPR to mobilize Ca(2+) and mediate formyl methionyl leucyl phenylalanine (fMLP)-stim...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.fp0072083

    authors： Morita K,Saida M,Morioka N,Kitayama T,Akagawa Y,Dohi T

    更新日期：2008-03-01 00:00:00

  • New topics in vasopressin receptors and approach to novel drugs: involvement of vasopressin V1a and V1b receptors in nociceptive responses and morphine-induced effects.

    abstract：:Arginine vasopressin (AVP) receptors have been classified into V1a, V1b, and V2 subtypes. Recent studies have demonstrated the involvement of AVP in anti-nociception and in morphine-induced anti-nociception. However, the roles of individual AVP-receptor subtypes have not been fully elucidated. Here, we have summarized...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章,评审

    doi：10.1254/jphs.08r30fm

    authors： Honda K,Takano Y

    更新日期：2009-01-01 00:00:00

  • Role of neurosteroid allopregnanolone on age-related differences in exercise-induced hypoalgesia in rats.

    abstract：:The beneficial effects of physical activity for pain are denominated exercise-induced hypoalgesia (EIH). Here, we examined the age-related change and potential role of the neurosteroid allopregnanolone (ALLO) on EIH in rats. Adult and aged rats were randomly divided into one of three groups; non-exercise control, Low-...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2018.11.009

    authors： Aoyama B,Kawano T,Iwata H,Nishigaki A,Yamanaka D,Tateiwa H,Shigematsu-Locatelli M,Eguchi S,Locatelli FM,Yokoyama M

    更新日期：2019-02-01 00:00:00

  • Possible involvement of endogenous opioid system located downstream of α7 nicotinic acetylcholine receptor in mice with physical dependence on nicotine.

    abstract：:We previously reported that nicotine (NIC)-induced analgesia was elicited in part by activation of the endogenous opioid system. Moreover, it is well known that NIC has physical-dependence liability, but its mechanism is unclear. Therefore, we examined whether physical dependence on NIC was mediated by activation of t...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.13172fp

    authors： Ueno K,Kiguchi N,Kobayashi Y,Saika F,Wakida N,Yamamoto C,Maeda T,Ozaki M,Kishioka S

    更新日期：2014-01-01 00:00:00

  • Cucurbitacin B induces inhibitory effects via the CIP2A/PP2A/C-KIT signaling axis in t(8;21) acute myeloid leukemia.

    abstract：:Acute myeloid leukemia (AML) is the most common subtype of hematological malignancy in humans, and its incidence increases with age. The treatment of AML still faces challenges. Therefore, there is an urgent need to develop more effective targeted therapies. The receptor tyrosine kinase C-KIT confers critical prolifer...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2018.12.010

    authors： Ma W,Xiang Y,Yang R,Zhang T,Xu J,Wu Y,Liu X,Xiang K,Zhao H,Liu Y,Si Y

    更新日期：2019-04-01 00:00:00

  • Schisandra chinensis acidic polysaccharide partialy reverses acetaminophen-induced liver injury in mice.

    abstract：:Schisandra chinensis is a hepatoprotective herb that has been used for centuries in China. Polysaccharide is one of the major active components in S. chinensis, which has been reported to improve liver injuries induced by carbon tetrachloride, alcohol, or high-fat diet. In this study, we observed the effects and corre...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2019.07.008

    authors： Che J,Yang S,Qiao Z,Li H,Sun J,Zhuang W,Chen J,Wang C

    更新日期：2019-07-01 00:00:00

  • History of the G protein-coupled receptor (GPCR) assays from traditional to a state-of-the-art biosensor assay.

    abstract：:The G protein-coupled receptors (GPCRs) form the largest and the most versatile superfamily that share a seven-transmembrane-spanning architecture. GPCR-signaling is involved in vision, taste, olfaction, sympathetic/parasympathetic nervous functions, metabolism, and immune regulation, indicating that GPCRs are extreme...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章,评审

    doi：10.1254/jphs.14R13CP

    authors： Miyano K,Sudo Y,Yokoyama A,Hisaoka-Nakashima K,Morioka N,Takebayashi M,Nakata Y,Higami Y,Uezono Y

    更新日期：2014-01-01 00:00:00

  • Blonanserin suppresses impulsive action in rats.

    abstract：:High impulsivity will increase the risk of criminal behavior, drug abuse, and suicide. We chose two drugs by following a strategy recently we proposed for identifying potential anti-impulsivity drugs, and examined the effects on impulsive action in rats by using a 3-choice serial reaction time task. We showed that the...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2019.09.013

    authors： Nishitani N,Sasamori H,Ohmura Y,Yoshida T,Yoshioka M

    更新日期：2019-11-01 00:00:00

  • Pharmacology in health foods: effects of arachidonic acid and docosahexaenoic acid on the age-related decline in brain and cardiovascular system function.

    abstract：:Arachidonic acid (ARA) and docosahexaenoic acid (DHA) are major constituents of cell membranes and play important roles in preserving physiological and psychological function. Recently, data from several studies have indicated that impairments in long-term potentiation (LTP), the process underlying plasticity in synap...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章,评审

    doi：10.1254/jphs.10r39fm

    authors： Kiso Y

    更新日期：2011-01-01 00:00:00

  • Effect of lamotrigine on Na(v)1.4 voltage-gated sodium channels.

    abstract：:Lamotrigine (LTG) is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder and it has been known that LTG targets voltage-dependent sodium channels (VGSCs). In this study, we investigated the effect of LTG on the Nav1.4 Na(+) current using HEK293 cells expressing mouse Nav1.4 VGSCs. By the trea...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.13116sc

    authors： Nakatani Y,Masuko H,Amano T

    更新日期：2013-01-01 00:00:00

  • Effects of anti-osteoporosis drugs against dexamethasone-induced osteoporosis-like phenotype using a zebrafish scale-regeneration model.

    abstract：:There are several animal models of glucocorticoid-induced osteoporosis (GIOP), but each requires a long time to evaluate drug effects. Zebrafish scales are classified as dermal bone and potentially represent a convenient animal model of GIOP because they rapidly regenerate following their removal. We clarified that de...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2020.02.011

    authors： Saito Y,Nakamura S,Chinen N,Shimazawa M,Hara H

    更新日期：2020-06-01 00:00:00

  • Simvastatin, an HMG-CoA reductase inhibitor, reduced the expression of matrix metalloproteinase-9 (Gelatinase B) in osteoblastic cells and HT1080 fibrosarcoma cells.

    abstract：:MMP-9 or Gelatinase B, a member of the matrix metalloproteinase family (MMPs), plays important roles in physiological events such as tissue remodeling and in pathological processes that lead to destructive bone diseases, including osteoarthritis and periodontitis. In addition to its effect on the increase of total bon...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.94.403

    authors： Thunyakitpisal PD,Chaisuparat R

    更新日期：2004-04-01 00:00:00

  • Alleviation of the doxorubicin-induced nephrotoxicity by fasudil in vivo and in vitro.

    abstract：OBJECTIVE:Treatment with the chemotherapeutic agent, doxorubicin (DOX), is limited by side effects. We have previously demonstrated that fasudil, a Rho/ROCK inhibitor, has antioxidant, anti-inflammatory and anti-apoptotic effects in contrast-induced acute kidney injury model. The present study to investigated the possi...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2020.10.002

    authors： Xiang C,Yan Y,Zhang D

    更新日期：2021-01-01 00:00:00

  • Vanadate activates Rho A translocation in association with contracting effects in ileal longitudinal smooth muscle of guinea pig.

    abstract：:We characterized the effects of vanadate, an inhibitor of tyrosine phosphatase, on the tension, the level of myosin light chain (MLC) phosphorylation, and Rho A activation in intact ileal longitudinal smooth muscle of the guinea pig to study the role of tyrosine phosphorylation in contraction signaling. Vanadate exert...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.fp0030576

    authors： Mori M,Tsushima H

    更新日期：2004-08-01 00:00:00

  • Recent advances in intravital imaging of dynamic biological systems.

    abstract：:Intravital multiphoton microscopy has opened a new era in the field of biological imaging. Focal excitation of fluorophores by simultaneous attack of multiple (normally "two") photons generates images with high spatial resolution, and use of near-infrared lasers for multiphoton excitation allows penetration of thicker...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章,评审

    doi：10.1254/jphs.12r03cp

    authors： Kikuta J,Ishii M

    更新日期：2012-01-01 00:00:00

  • Antivasospastic effects of hydroxyfasudil, a Rho-kinase inhibitor, after subarachnoid hemorrhage.

    abstract：:We investigated the anti-vasospastic potential of fasudil's active metabolite, hydroxyfasudil, a Rho-kinase inhibitor, after subarachnoid hemorrhage (SAH) and also its effect on hemorheological abnormalities following cerebral ischemia. Chronic cerebral vasospasm was produced using a two-hemorrhage canine model. On da...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.11075fp

    authors： Satoh S,Takayasu M,Kawasaki K,Ikegaki I,Hitomi A,Yano K,Shibuya M,Asano T

    更新日期：2012-01-01 00:00:00

  • The systemic bone protective effects of Gushukang granules in ovariectomized mice by inhibiting osteoclastogenesis and stimulating osteoblastogenesis.

    abstract：:Primary osteoporosis (POP), which is caused by unbalanced bone remodeling, leads to significant economic and societal burdens globally. Gushukang (GSK) granule serves as one commonly used prescription for POP in Traditional Chinese Medicine (TCM). The present study aimed to clarify the exact roles of GSK in bone remod...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2018.01.007

    authors： Wang Q,Zhao Y,Sha N,Zhang Y,Li C,Zhang H,Tang D,Lu S,Shi Q,Wang Y,Shu B,Zhao D

    更新日期：2018-03-01 00:00:00

  • Lysophosphatidic acid (LPA) induces plasma exudation and histamine release in mice via LPA receptors.

    abstract：:Lysophosphatidic acid (LPA), the simplest of the water-soluble phospholipids, can evoke various biological responses. The present study examined the activity of LPA to induce plasma exudation and histamine release in mice. Plasma exudation was assessed by extravasation of Evans blue. Subcutaneous administration of LPA...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.fpj05030x

    authors： Hashimoto T,Ohata H,Honda K

    更新日期：2006-01-01 00:00:00

  • Transcriptional regulation of neuronal genes and its effect on neural functions: transcriptional regulation of neuropeptide Y gene by leptin and its effect on feeding.

    abstract：:Leptin is an adipose tissue-derived secretory hormone that suppresses appetite by inhibition of neuropepeptide Y (NPY) gene expression in arcuate nucleus (ARC) in the hypothalamus. To investigate the transcriptional regulation of NPY gene by leptin, we carried out a luciferase assay using NPY gene promotor plasmid (NP...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章,评审

    doi：10.1254/jphs.fmj05001x6

    authors： Higuchi H,Hasegawa A,Yamaguchi T

    更新日期：2005-07-01 00:00:00

  • Stress and vascular responses: oxidative stress and endothelial dysfunction in the insulin-resistant state.

    abstract：:Although insulin-resistant states have been associated with endothelial dysfunction due to increased vascular oxidative stress, the underlying mechanisms are pooly understood. Recent experimental evidence suggests that tetrahydrobiopterin (BH(4)), the natural and essential cofactor of NO synthases (NOS), plays a cruci...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章,评审

    doi：10.1254/jphs.91.187

    authors： Shinozaki K,Kashiwagi A,Masada M,Okamura T

    更新日期：2003-03-01 00:00:00