Abstract:
:Lamotrigine (LTG) is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder and it has been known that LTG targets voltage-dependent sodium channels (VGSCs). In this study, we investigated the effect of LTG on the Nav1.4 Na(+) current using HEK293 cells expressing mouse Nav1.4 VGSCs. By the treatment of LTG, Nav1.4 Na(+) current was inhibited in a dose-dependent manner. Moreover, 100 μM LTG decreased Nav1.4 Na(+) current around 40% and shifted the V1/2 of the inactivation curve to the hyperpolarization side by 20.96 mV. These findings suggest that LTG inhibits Nav1.4 Na(+) current and modifies the kinetics of the inactivated state.
journal_name
J Pharmacol Scijournal_title
Journal of pharmacological sciencesauthors
Nakatani Y,Masuko H,Amano Tdoi
10.1254/jphs.13116scsubject
Has Abstractpub_date
2013-01-01 00:00:00pages
203-6issue
2eissn
1347-8613issn
1347-8648pii
DN/JST.JSTAGE/jphs/13116SCjournal_volume
123pub_type
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