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Polaprezinc reduces paclitaxel-induced peripheral neuropathy in rats without affecting anti-tumor activity.

Abstract：

:Paclitaxel, an anticancer drug, frequently causes painful peripheral neuropathy. In this study, we investigated the preventive effect of polaprezinc on paclitaxel-induced peripheral neuropathy in rats. Polaprezinc (3 mg/kg, p.o., once daily) inhibited the development of mechanical allodynia induced by paclitaxel (4 mg/kg, i.p., on days 1, 3, 5 and 7) and suppressed the paclitaxel-induced increase in macrophage migration in dorsal root ganglion cells. In addition, polaprezinc did not affect the anti-tumor activity of paclitaxel in cultured cell lines or tumor-bearing mice. These results suggest a clinical indication for polaprezinc in the prevention of paclitaxel-induced neuropathy.

journal_name

J Pharmacol Sci

journal_title

Journal of pharmacological sciences

authors

Tsutsumi K,Kaname T,Shiraishi H,Kawashiri T,Egashira N

doi

10.1016/j.jphs.2016.04.019

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

146-9

issue

2

eissn

1347-8613

issn

1347-8648

pii

S1347-8613(16)30036-6

journal_volume

131

pub_type

杂志文章

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