Abstract:
:Since induced pluripotent stem cells (iPSCs) were generated from mice and humans by Professor Shinya Yamanaka et al. in 2006 and 2007, respectively, a variety of human-derived cells have been generated, including myocardial, liver, retinal pigment epithelial, and neuronal cells. These iPSCs are now used not only in clinical research focusing on regeneration and transplantation in diverse medical fields, but also in molecular and cellular pathological studies. Importantly, by using human-derived iPSCs, it has become possible to conduct drug discovery research that more accurately models the pathology of human diseases. In research on psychiatric disorders, iPSC-related technologies, which have enabled the use of neuronal cells that carry the genetic information of the patients, will be important for elucidating not only the molecular and cellular etiology of psychiatric disorders but also the molecular mechanisms of drug action in these disorders. This review outlines the pharmacological research of psychiatric disorders that utilizes iPSC-related technologies.
journal_name
J Pharmacol Scijournal_title
Journal of pharmacological sciencesauthors
Nakazawa T,Hashimoto R,Takuma K,Hashimoto Hdoi
10.1016/j.jphs.2019.06.002subject
Has Abstractpub_date
2019-08-01 00:00:00pages
321-324issue
4eissn
1347-8613issn
1347-8648pii
S1347-8613(19)34167-2journal_volume
140pub_type
杂志文章,评审abstract::The roles played by K+ channels in the urothelium (UE) and detrusor smooth muscle (DSM) in regulating agonist-induced bladder contraction is not known at present. Thus, the effects in carbachol (CCh)-induced contraction in UE-intact (+UE) and UE-denuded (-UE) rat detrusor strips pretreated with K+-channel blockers wer...
journal_title:Journal of pharmacological sciences
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journal_title:Journal of pharmacological sciences
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abstract::The role of nitric oxide (NO) on intestinal mucosal injury induced by single or consecutive administration of methotrexate was investigated in a rodent model. Rats received methotrexate intraperitoneally either as a single administration (50 mg/kg) or as a consecutive administration (12.5 mg/kg/day) for 4 days. NG-nit...
journal_title:Journal of pharmacological sciences
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journal_title:Journal of pharmacological sciences
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journal_title:Journal of pharmacological sciences
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journal_title:Journal of pharmacological sciences
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journal_title:Journal of pharmacological sciences
pub_type: 杂志文章,评审
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journal_title:Journal of pharmacological sciences
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journal_title:Journal of pharmacological sciences
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abstract::In the novel object recognition task, ZSET1446 (also coded as ST101) enhanced object recognition memory in mice and ameliorated cognitive impairment caused by scopolamine in rats. The enhancement induced by ZSET1446 in mice was abolished by injection of mechamylamine, a nonselective antagonist of nicotinic acetylcholi...
journal_title:Journal of pharmacological sciences
pub_type: 杂志文章
doi:10.1254/jphs.13042fp
更新日期:2013-01-01 00:00:00
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journal_title:Journal of pharmacological sciences
pub_type: 杂志文章
doi:10.1016/j.jphs.2016.04.019
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journal_title:Journal of pharmacological sciences
pub_type: 杂志文章
doi:10.1016/j.jphs.2015.03.004
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abstract::Yeasts isolated from patients with superficial mycoses were tested against propolis samples collected from different regions and honeybee races. The minimum inhibitory concentration (MIC) values obtained using the agar dilution methods were compared to the diameters of growth inhibition zones by using the disk diffusi...
journal_title:Journal of pharmacological sciences
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journal_title:Journal of pharmacological sciences
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更新日期:2013-01-01 00:00:00
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journal_title:Journal of pharmacological sciences
pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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abstract::Calf Spleen Extractive Injection (CSEI), a small peptides enriched extraction, performs immunomodulatory activity on cancer patients suffering from radiotherapy or chemotherapy. The present study aims to investigate the anti-hepatocellular carcinoma effects of CSEI in cells and tumor-xenografted mouse models. In HepG2...
journal_title:Journal of pharmacological sciences
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journal_title:Journal of pharmacological sciences
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journal_title:Journal of pharmacological sciences
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journal_title:Journal of pharmacological sciences
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journal_title:Journal of pharmacological sciences
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journal_title:Journal of pharmacological sciences
pub_type: 杂志文章
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更新日期:2018-01-01 00:00:00
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journal_title:Journal of pharmacological sciences
pub_type: 杂志文章
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更新日期:2005-03-01 00:00:00
abstract::The supraspinal and spinal antinociceptive effects of several kappa-opioid receptor agonists were examined in diabetic and non-diabetic mice using the tail-flick assay. The antinociception induced by intrathecal (i.t.), but not intracerebroventricular (i.c.v.), CI-977, a highly selective kappa(1)-opioid receptor agoni...
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