Abstract:
:We studied the pronociceptive role of proteinase-activated receptor-2 (PAR2) in mouse bladder. In female mice, intravesical infusion of the PAR2-activating peptide, SLIGRL-amide (SL), caused delayed mechanical hypersensitivity in the lower abdomen, namely 'referred hyperalgesia', 6-24 h after the administration. The PAR2-triggered referred hyperalgesia was prevented by indomethacin or a selective TRPV1 blocker, and restored by a T-type Ca2+ channel blocker. In human urothelial T24 cells, SL caused delayed prostaglandin E2 production and COX-2 upregulation. Our data suggest that luminal PAR2 stimulation in the bladder causes prostanoid-dependent referred hyperalgesia in mice, which involves the activation of TRPV1 and T-type Ca2+ channels.
journal_name
J Pharmacol Scijournal_title
Journal of pharmacological sciencesauthors
Tsubota M,Ozaki T,Hayashi Y,Okawa Y,Fujimura A,Sekiguchi F,Nishikawa H,Kawabata Adoi
10.1016/j.jphs.2017.12.007subject
Has Abstractpub_date
2018-01-01 00:00:00pages
46-49issue
1eissn
1347-8613issn
1347-8648pii
S1347-8613(17)30210-4journal_volume
136pub_type
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