Effect of selective serotonin reuptake inhibitors via 5-HT1A receptors on L-DOPA-induced rotational behavior in a hemiparkinsonian rat model.

abstract：:Peripheral-type benzodiazepine receptor (PBR) and central-type benzodiazepine receptor (CBR) in salivary gland play a role in the inhibitory regulation of salivary secretion in rodents. Diazepam-binding inhibitor (DBI), an endogenous ligand for PBR, produces neurosteroids, which modulate CBR activity. In this study, w...

journal_title：Journal of pharmacological sciences

authors： Tsukagoshi E,Kawaguchi M,Shinomiya T,Yoshikawa M,Kawano T,Okubo M,Sawaki K

更新日期：2011-01-01 00:00:00

abstract：:Patients with obstructive sleep apnea (OSA) have a high prevalence of atrial fibrillation (AF). Rivaroxaban, a coagulation factor Xa inhibitor, has recently been reported to show pleiotropic effects. This study investigated the influence of rivaroxaban on cardiac remodeling caused by intermittent hypoxia (IH). Male C5...

journal_title：Journal of pharmacological sciences

authors： Imano H,Kato R,Tanikawa S,Yoshimura F,Nomura A,Ijiri Y,Yamaguchi T,Izumi Y,Yoshiyama M,Hayashi T

更新日期：2018-07-01 00:00:00

abstract：:Hot flushes are the most common complaint of menopausal women. In the present study, a new animal model of hot flushes was established. Tail skin temperature was measured with a thermo tracer after mice were subjected to a forced exercise task using a motor driven treadmill. In ovariectomized mice, forced exercise for...

journal_title：Journal of pharmacological sciences

authors： Shuto H,Yamauchi A,Ikeda M,Sohda Y,Koga A,Tominaga K,Egawa T,Kataoka Y

更新日期：2005-07-01 00:00:00

abstract：:Luminal hydrogen sulfide (H(2)S), a gasotransmitter, causes colonic pain / referred hyperalgesia in mice, most probably via activation of T-type Ca(2+) channels. Here we analyzed the mechanisms for H(2)S-induced facilitation of colonic pain signals. Intracolonic administration of NaHS, an H(2)S donor, evoked visceral ...

journal_title：Journal of pharmacological sciences

authors： Tsubota-Matsunami M,Noguchi Y,Okawa Y,Sekiguchi F,Kawabata A

更新日期：2012-01-01 00:00:00

abstract：:In this study, we clarified the intracellular mechanism of angiotensin II (Ang II) in promoting migration in rat aortic smooth muscle cells (RASMCs). RASMC migration was measured with the Boyden chamber assay, and the result was confirmed with an aortic sprout assay. The activities of kinases were investigated by west...

journal_title：Journal of pharmacological sciences

authors： Lee HM,Lee CK,Lee SH,Roh HY,Bae YM,Lee KY,Lim J,Park PJ,Park TK,Lee YL,Won KJ,Kim B

更新日期：2007-09-01 00:00:00

abstract：:We recently developed a novel cognitive enhancer, ST101 (spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one), that activates T-type voltage-gated calcium channels (VGCCs). Here, we address whether T-type VGCC activation with ST101 mediates its cognitive effects in vivo and the relevance of T-type VGCC activation to ace...

journal_title：Journal of pharmacological sciences

authors： Yamamoto Y,Shioda N,Han F,Moriguchi S,Fukunaga K

更新日期：2013-01-01 00:00:00

abstract：:Atherosclerotic lesions were observed in male and ovariectomized female Microminipig (MMP) fed a high fat and cholesterol diet with sodium cholate (HFCD/SC) for 3 months. HFCD/SC induced hypercholesterolemia accompanied by an increase in serum total cholesterol (T-Cho), low-density lipoprotein cholesterol (LDL-C), hig...

journal_title：Journal of pharmacological sciences

authors： Kawaguchi H,Miyoshi N,Miura N,Fujiki M,Horiuchi M,Izumi Y,Miyajima H,Nagata R,Misumi K,Takeuchi T,Tanimoto A,Yoshida H

更新日期：2011-01-01 00:00:00

abstract：:Primary osteoporosis (POP), which is caused by unbalanced bone remodeling, leads to significant economic and societal burdens globally. Gushukang (GSK) granule serves as one commonly used prescription for POP in Traditional Chinese Medicine (TCM). The present study aimed to clarify the exact roles of GSK in bone remod...

journal_title：Journal of pharmacological sciences

authors： Wang Q,Zhao Y,Sha N,Zhang Y,Li C,Zhang H,Tang D,Lu S,Shi Q,Wang Y,Shu B,Zhao D

更新日期：2018-03-01 00:00:00

abstract：:Neurosteroids are known as allosteric modulators of the ligand-gated ion channel superfamily. Voltage-gated sodium channels (Na(v)) play an important role in mediating excitotoxic damages. Here we report the effects of neurosteroids on the function of Na(v), using voltage-clamp techniques in Xenopus oocytes expressed ...

journal_title：Journal of pharmacological sciences

authors： Horishita T,Ueno S,Yanagihara N,Sudo Y,Uezono Y,Okura D,Sata T

更新日期：2012-01-01 00:00:00

abstract：:This study examines the influence of receptor expression level on signaling pathways activated via endothelin type A receptor (ET(A)R) expressed in Chinese hamster ovary cells at 32,100 (ET(A)R-high-CHO) and 893 (ET(A)R-low-CHO) fmolmg protein(-1). Endothelin-1 (ET-1) elicited a sustained increase in intracellular Ca(...

journal_title：Journal of pharmacological sciences

authors： Horinouchi T,Asano H,Higa T,Nishimoto A,Nishiya T,Muramatsu I,Miwa S

更新日期：2009-12-01 00:00:00

abstract：:Many kinds of vasodilators induce relaxation of the vascular smooth muscle cells (VSMCs) through the production of cyclic AMP (cAMP) or cyclic GMP (cGMP). The relaxant effects mediated by these second messengers are thought to be mainly due to the decrease in intracellular Ca(2+) concentration ([Ca(2+)](i)), as well a...

journal_title：Journal of pharmacological sciences

authors： Nishimura J

更新日期：2006-09-01 00:00:00

abstract：:Platelet activation is the primary cause of thrombosis. The P2X7 receptor (P2X7R) is a therapeutic target of thrombosis. However, it is still unknown whether P2X7R activation affects platelet thrombus. Our molecular docking results showed that entecavir as a P2X7R antagonist interacted perfectly with the human P2X7R (...

journal_title：Journal of pharmacological sciences

authors： Ming Y,Xin G,Ji B,Ji C,Wei Z,Zhang B,Zhang J,Yu K,Zhang X,Li S,Li Y,Xing Z,Niu H,Huang W

更新日期：2020-09-01 00:00:00

abstract：:G protein-coupled receptors, in particular, Ca(2+)-mobilizing G(q)-coupled receptors have been reported to be targets for anesthetics. Opioids are commonly used analgesics in clinical practice, but the effects of anesthetics on the opioid mu-receptors (muOR) have not been systematically examined. We report here an ele...

journal_title：Journal of pharmacological sciences

authors： Minami K,Sudo Y,Shiraishi S,Seo M,Uezono Y

更新日期：2010-01-01 00:00:00

abstract：:We have reported that the differentiation-inducing factors (DIFs) DIF-1 and DIF-3, morphogens secreted from Dictyostelium discoideum, inhibit proliferation of several cancer cells via suppression of the Wnt/beta-catenin signaling pathway. However, the target molecules of DIFs involved in the anti-proliferative effects...

journal_title：Journal of pharmacological sciences

authors： Matsuda T,Takahashi-Yanaga F,Yoshihara T,Maenaka K,Watanabe Y,Miwa Y,Morimoto S,Kubohara Y,Hirata M,Sasaguri T

更新日期：2010-01-01 00:00:00

abstract：:We investigated the anesthetic effects of propofol on the electrocardiogram (ECG) in mice. We also compared the effects of isoflurane (2%) inhalation anesthesia, intraperitoneal propofol (50 or 100 mg/kg), and pentobarbital (50 mg/kg) on ECG in mice. Isoflurane inhalation and pentobarbital anesthesia were both associa...

journal_title：Journal of pharmacological sciences

authors： Shintaku T,Ohba T,Niwa H,Kushikata T,Hirota K,Ono K,Matsuzaki Y,Imaizumi T,Kuwasako K,Sawamura D,Murakami M

更新日期：2014-01-01 00:00:00

abstract：:To investigate whether miniature pigs are useful for evaluating the potential of drugs for drug-induced prolongation of the QT interval, we performed an in vivo QT assay using conscious and unrestricted miniature pigs. Compared with the vehicle average baseline values, haloperidol at 3 and 10 mg/kg, p.o. prolonged the...

journal_title：Journal of pharmacological sciences

authors： Kano M,Toyoshi T,Iwasaki S,Kato M,Shimizu M,Ota T

更新日期：2005-01-01 00:00:00

abstract：:Kursi Wufarikun Ziyabit (KWZ) is a traditional prescription that used in folk tea drinking for its health care effect in treatment of type 2 diabetes mellitus (T2DM) in central Asia. However, the underlying mechanism of KWZ in T2DM has not been investigated extensively. This study designed to observe the effect of KWZ...

journal_title：Journal of pharmacological sciences

authors： Edirs S,Jiang L,Xin X,Aisa HA

更新日期：2018-06-01 00:00:00

abstract：:Simultaneous administration of psychostimulants and opioids is a major drug abuse problem worldwide. This combination appears to produce synergistic effects on behavior at low doses; however, there is little direct evidence that the combination is stronger than either drug alone. Therefore, we investigated interaction...

journal_title：Journal of pharmacological sciences

authors： Mori T,Ito S,Narita M,Suzuki T,Sawaguchi T

更新日期：2004-12-01 00:00:00

abstract：:The maladaptive response of aged microglia to surgery and consequent neuroinflammation plays a key pathogenic role in postoperative cognitive dysfunction (POCD). Here, we assessed the preventive effect of resveratrol (RESV) for POCD in aged rats. The emulsified form of RESV (e-RESV) was selected to improve its oral an...

journal_title：Journal of pharmacological sciences

authors： Locatelli FM,Kawano T,Iwata H,Aoyama B,Eguchi S,Nishigaki A,Yamanaka D,Tateiwa H,Shigematsu-Locatelli M,Yokoyama M

更新日期：2018-08-01 00:00:00

abstract：:Functional dyspepsia (FD) is thought to be mainly based on gastric motility dysfunction and chronic hypersensitivity, yet FD animal models has been reported a few. We studied to establish the mouse model of impaired gastric motility induced by a pungent ingredient of wasabi allyl isothiocyanate (AITC), which is reliab...

journal_title：Journal of pharmacological sciences

authors： Hashimoto K,Tashima K,Imai T,Matsumoto K,Horie S

更新日期：2021-01-01 00:00:00

abstract：:Although cyclic ADP-ribose (cADPR), a novel Ca(2+)-mobilizing mediator, is suggested to be involved in the functions of neutrophils in rodents, its role in human neutrophils remains unclear. The present study examined the ability of cADPR to mobilize Ca(2+) and mediate formyl methionyl leucyl phenylalanine (fMLP)-stim...

journal_title：Journal of pharmacological sciences

authors： Morita K,Saida M,Morioka N,Kitayama T,Akagawa Y,Dohi T

更新日期：2008-03-01 00:00:00

abstract：:P-glycoprotein (P-gp)-induced drug resistance is a major road block for successful cancer chemotherapy. Through phenotypic screening, the compound 2-(2-chlorophenylimino)-5-(4-dimethylaminobenzylidene) thiazolidin-4-one (CDBT) was discovered to have potent anti-tumor activity in P-gp over-expressing drug-resistant non...

journal_title：Journal of pharmacological sciences

authors： Zhang Q,Zhai S,Li L,Li X,Jiang C,Zhang C,Yan B

更新日期：2014-01-01 00:00:00

abstract：:Na+, K+-ATPase is a highly expressed membrane protein. Dysfunction of Na+, K+-ATPase has been implicated in the pathophysiology of several neurodegenerative and psychiatric disorders, however, the underlying mechanism of neuronal cell death resulting from Na+, K+-ATPase dysfunction is poorly understood. Here, we inves...

journal_title：Journal of pharmacological sciences

authors： Kurauchi Y,Noma K,Hisatsune A,Seki T,Katsuki H

更新日期：2018-11-01 00:00:00

abstract：:A possible involvement of histamine in acute radiation dermatitis in mice was investigated. The dose of 40 Gy of gamma irradiation induced erythema and edema in C57BL/6 mice treated with vehicle. However, in C57BL/6 mice treated with chlorpheniramine and WBB6F1-W/Wv mice, erythema and edema were not observed. In all o...

journal_title：Journal of pharmacological sciences

authors： Moriyasu S,Yamamoto K,Kureyama N,Okamura K,Ikeda T,Yamatodani A

更新日期：2007-06-01 00:00:00

abstract：:Aristolochic acids (AAs), contained in Chinese herbal preparations, have been considered to induce nephropathy. In order to elucidate the molecular mechanisms of AA-induced nephrotoxicity, we have elucidated the interaction of human organic anion transporters (hOATs) with AAs using their stable cell lines. AA-I and AA...

journal_title：Journal of pharmacological sciences

authors： Babu E,Takeda M,Nishida R,Noshiro-Kofuji R,Yoshida M,Ueda S,Fukutomi T,Anzai N,Endou H

更新日期：2010-01-01 00:00:00

abstract：:To elucidate the mechanism of action of prostaglandin I(2) (PGI(2)) and carbaprostacyclin, we studied their effect on DNA synthesis and proliferation in primary cultures of adult rat hepatocytes. Hepatocyte parenchymal cells, maintained in a serum-free, defined medium, synthesized DNA and proliferated in the presence ...

journal_title：Journal of pharmacological sciences

authors： Kimura M,Okamoto H,Natsume H,Ogihara M

更新日期：2009-04-01 00:00:00

abstract：:The purpose of the current study was to explore the effects of N-methyl-D-aspartate (NMDA)-receptor antagonists (MK-801 and LY235959) administered intracerebroventricularly on the changes of both core temperature and hypothalamic levels of 2,3-dihydroxybenzoic acid (2,3-DHBA) induced by intracerebroventricular injecti...

journal_title：Journal of pharmacological sciences

authors： Kao CH,Kao TY,Huang WT,Lin MT

更新日期：2007-06-01 00:00:00

abstract：:The optimum strategy for heart failure (HF) treatment has yet to be elucidated. This study intended to test the benefit of a combination of valsartan (VAL) and perifosine (PER), a specific AKT inhibitor, in protecting against pressure overload induced mouse HF. Mouse were subjected to aortic banding (AB) surgery to es...

journal_title：Journal of pharmacological sciences

authors： Li WJ,Liao HH,Feng H,Zhou ZY,Mou SQ,Zhang N,Wu HM,Xia H,Tang QZ

更新日期：2020-07-01 00:00:00

abstract：:Rapid-scanning cofocal microscopy has been applied to the analysis of early phase Ca(2+) transients in ventricular and atrial cardiomyocytes. On electrical stimulation of ventricular myocytes, Ca(2+) concentration begins to rise earliest at the Z-line level and becomes uniform throughout the cytoplasm within about 10 ...

journal_title：Journal of pharmacological sciences

authors： Tanaka H,Kawanishi T,Shigenobu K

更新日期：2003-11-01 00:00:00

abstract：:Bee venom (BV) has been used in patients with rheumatoid arthritis, a condition characterized by rheumatoid joint destruction mediated, in large part, by matrix metalloproteinases (MMPs). We investigated the effects of melittin, a major component of bee venom, on the production of MMPs in human rheumatoid arthritic fi...

journal_title：Journal of pharmacological sciences

authors： Nah SS,Ha E,Mun SH,Won HJ,Chung JH

更新日期：2008-01-01 00:00:00