Abstract:
:We compared dilator actions of representative four Ca2+ channel blockers on the isolated lower esophagus sphincter (LES) and thoracic aorta from rats. Verapamil, diltiazem, nifedipine and cilnidipine suppressed KCl-induced contractions of LES and thoracic aorta in a concentration-dependent manner. The order of selectivity for LES, which was calculated as ratio of IC50 value for thoracic aorta divided by that for LES, was diltiazem > verapamil > nifedipine > cilnidipine. These results suggest that diltiazem more preferentially dilates the LES whereas cilnidipine is expected to have lower potential risk of gastroesophageal dysfunction during the antihypertensive therapy.
journal_name
J Pharmacol Scijournal_title
Journal of pharmacological sciencesauthors
Takahara A,Nozaki S,Ishiguro A,Okamura K,Cao X,Aimoto M,Nagasawa Ydoi
10.1016/j.jphs.2018.01.012subject
Has Abstractpub_date
2018-05-01 00:00:00pages
98-100issue
1eissn
1347-8613issn
1347-8648pii
S1347-8613(18)30070-7journal_volume
137pub_type
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