当前位置： SCI文献检索 > JOURNAL OF PHARMACOLOGICAL SCIENCES期刊下所有文献 > Alleviating effects of AS1892802, a Rho kinase inhibitor, on osteoarthritic disorders in rodents.

Alleviating effects of AS1892802, a Rho kinase inhibitor, on osteoarthritic disorders in rodents.

Abstract：

:The effects of AS1892802, a selective Rho-associated coiled coil kinase (ROCK) inhibitor, on knee cartilage damage and pain behavior were examined in a rat model of osteoarthritis (OA). Monoiodoacetate (MIA) was intraarticularly injected into the right knee joints of rats. ROCK I and II mRNA levels increased in knee joints of MIA-injected rats. Our newly synthesized ROCK inhibitor, AS1892802, was injected into the ipsilateral knee or administered p.o. for 3 weeks. The compound dose-dependently and significantly inhibited of cartilage damage in the tibial plateau in a dose-dependent manner and decreased the weight distribution deficit associated with MIA injection. In addition, the compound also inhibited bradykinin induced pain responses in normal rats. In vitro, the compound could induce chondrocyte differentiation in a chondrogenic cell line and significantly inhibited IL-1β- or bradykinin-induced prostaglandin E(2) production in a synovial cell line. AS1892802 prevents cartilage damage induced by MIA and has analgesic effects in rat pain models, suggesting that AS1892802 may be clinically useful for the treatment of OA.[Supplementary Figure: available only at http://dx.doi.org/10.1254/jphs.10319FP].

journal_name

J Pharmacol Sci

journal_title

Journal of pharmacological sciences

authors

Takeshita N,Yoshimi E,Hatori C,Kumakura F,Seki N,Shimizu Y

doi

10.1254/jphs.10319fp

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

481-9

issue

4

eissn

1347-8613

issn

1347-8648

pii

JST.JSTAGE/jphs/10319FP

journal_volume

115

pub_type

杂志文章

相关文献

JOURNAL OF PHARMACOLOGICAL SCIENCES文献大全
  • Apelin protects against NMDA-induced retinal neuronal death via an APJ receptor by activating Akt and ERK1/2, and suppressing TNF-α expression in mice.

    abstract：:Glutamate excitotoxicity mediated by N-methyl-d-aspartate (NMDA) receptors is an important cause of retinal ganglion cell death in glaucoma. To elucidate whether apelin protects against retinal neuronal cell death, we examined protective effects of exogenous and endogenous apelin on neuronal cell death induced by intr...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2016.12.002

    authors： Ishimaru Y,Sumino A,Kajioka D,Shibagaki F,Yamamuro A,Yoshioka Y,Maeda S

    更新日期：2017-01-01 00:00:00

  • 2-aminophenoxazine-3-one prevents pulmonary metastasis of mouse B16 melanoma cells in mice.

    abstract：:2-Aminophenoxazine-3-one (Phx-3) induced cellular apoptosis in mouse melanoma B16 cells as detected by DNA laddering and upregulated Fas expression in the cells in vitro. Next, the anti-metastatic effects of Phx-3 were investigated in C56BL/6 mice. When B16 melanoma cells were injected into the tail veins of mice, sig...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.10023fp

    authors： Hongo T,Miyano-Kurosaki N,Kurosaki K,Hata A,Harigae S,Tomoda A

    更新日期：2010-01-01 00:00:00

  • Hepatoprotective effect of pinoresinol on carbon tetrachloride-induced hepatic damage in mice.

    abstract：:Forsythiae Fructus is known to have diuretic, anti-bacterial, and anti-inflammatory activities. This study examined the hepatoprotective effects of pinoresinol, a lignan isolated from Forsythiae Fructus, against carbon tetrachloride (CCl(4))-induced liver injury. Mice were treated intraperitoneally with vehicle or pin...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.09234fp

    authors： Kim HY,Kim JK,Choi JH,Jung JY,Oh WY,Kim DC,Lee HS,Kim YS,Kang SS,Lee SH,Lee SM

    更新日期：2010-01-01 00:00:00

  • Lipopolysaccharide- and glutamate-induced hypothalamic hydroxyl radical elevation and fever can be suppressed by N-methyl-D-aspartate-receptor antagonists.

    abstract：:The purpose of the current study was to explore the effects of N-methyl-D-aspartate (NMDA)-receptor antagonists (MK-801 and LY235959) administered intracerebroventricularly on the changes of both core temperature and hypothalamic levels of 2,3-dihydroxybenzoic acid (2,3-DHBA) induced by intracerebroventricular injecti...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.fp0070272

    authors： Kao CH,Kao TY,Huang WT,Lin MT

    更新日期：2007-06-01 00:00:00

  • Adoptive transfer of type 1 regulatory T cells suppressed the development of airway hyperresponsiveness in ovalbumin-induced airway inflammation model mice.

    abstract：:Type 1 regulatory T (Tr1) cells are CD4+ T cells that produce a large amount of IL-10, an anti-inflammatory cytokine. However, it has not been fully elucidated whether Tr1 cells suppress allergic asthma. In this study, the effects of adoptive transfer of in vitro-induced Tr1 cells on allergic asthma were evaluated. Sp...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2019.10.004

    authors： Matsuda M,Doi K,Tsutsumi T,Inaba M,Hamaguchi J,Terada T,Kawata R,Kitatani K,Nabe T

    更新日期：2019-12-01 00:00:00

  • The cannabinoid receptor agonist WIN 55212-2 inhibits neurogenic inflammations in airway tissues.

    abstract：:We examined the effects of a cannabinoid receptor agonist, (R)-(+)-[2,3-dihydro-5-methyl-3-[(4-merpholino)methyl]pyrrolo-[1,2,3-de]-1,4-benzoxazin-6-yl](1-naphthyl)methanone (WIN 55212-2), on various respiratory reactions induced by the activation of capsaicin-sensitive afferent sensory nerves (C-fibers). WIN 55212-2 ...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.fp0050171

    authors： Yoshihara S,Morimoto H,Ohori M,Yamada Y,Abe T,Arisaka O

    更新日期：2005-05-01 00:00:00

  • Unique immunomodulatory effect of paeoniflorin on type I and II macrophages activities.

    abstract：:It has been widely accepted that macrophages are divided into M1 "pro-inflammatory" macrophages and M2 "anti-inflammatory" macrophages and an uncontrolled macrophage polarization plays an important role in the pathogenesis of different diseases. As the main substance of total glucosides of peony, paeoniflorin (PF), ha...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2015.12.007

    authors： Zhai T,Sun Y,Li H,Zhang J,Huo R,Li H,Shen B,Li N

    更新日期：2016-03-01 00:00:00

  • Expression of cytosolic phospholipase A2 alpha in murine C12 cells, a variant of L929 cells, induces arachidonic acid release in response to phorbol myristate acetate and Ca2+ ionophores, but not to tumor necrosis factor-alpha.

    abstract：:Tumor necrosis factor-alpha (TNFalpha)-induced cell death is regulated through the release of arachidonic acid (AA) by group IVA cytosolic phospholipase A2 (cPLA2alpha) in the murine fibroblast cell line L929. However, the signaling pathway by which TNFalpha activates cPLA2alpha remained to be solved. We examined AA r...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.fpj04033x

    authors： Shimizu M,Azuma C,Taniguchi T,Murayama T

    更新日期：2004-11-01 00:00:00

  • Caspase mediated enhanced apoptotic action of cyclophosphamide- and resveratrol-treated MCF-7 cells.

    abstract：:Cyclophosphamide (CPA) is a widely used chemotherapeutic drug for neoplasias. It is a DNA and protein alkylating agent having a broad spectrum of activity against a variety of neoplasms including breast cancer. The therapeutic effectiveness of CPA is limited by the high-dose hematopoietic, renal, and cardiac toxicity ...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.08173fp

    authors： Singh N,Nigam M,Ranjan V,Sharma R,Balapure AK,Rath SK

    更新日期：2009-04-01 00:00:00

  • Nicotinic acetylcholine receptor alpha7 subunit mediates migration of vascular smooth muscle cells toward nicotine.

    abstract：:GbaSM-4 cells, vascular smooth muscle cells (VSMCs) derived from brain basilar arteries, were shown to migrate toward d-nicotine by augmenting the actin cytoskeleton in their cell bodies and lamellipodia, and expression of nicotinic acetylcholine receptor (alpha7-nAChR) was detected in GbaSM-4 cells. Their chemotaxis ...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.94.334

    authors： Li S,Zhao T,Xin H,Ye LH,Zhang X,Tanaka H,Nakamura A,Kohama K

    更新日期：2004-03-01 00:00:00

  • Recent advances in intravital imaging of dynamic biological systems.

    abstract：:Intravital multiphoton microscopy has opened a new era in the field of biological imaging. Focal excitation of fluorophores by simultaneous attack of multiple (normally "two") photons generates images with high spatial resolution, and use of near-infrared lasers for multiphoton excitation allows penetration of thicker...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章,评审

    doi：10.1254/jphs.12r03cp

    authors： Kikuta J,Ishii M

    更新日期：2012-01-01 00:00:00

  • New topics in vasopressin receptors and approach to novel drugs: involvement of vasopressin V1a and V1b receptors in nociceptive responses and morphine-induced effects.

    abstract：:Arginine vasopressin (AVP) receptors have been classified into V1a, V1b, and V2 subtypes. Recent studies have demonstrated the involvement of AVP in anti-nociception and in morphine-induced anti-nociception. However, the roles of individual AVP-receptor subtypes have not been fully elucidated. Here, we have summarized...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章,评审

    doi：10.1254/jphs.08r30fm

    authors： Honda K,Takano Y

    更新日期：2009-01-01 00:00:00

  • p38 mitogen-activated protein kinase contributes to angiotensin II-stimulated migration of rat aortic smooth muscle cells.

    abstract：:In this study, we clarified the intracellular mechanism of angiotensin II (Ang II) in promoting migration in rat aortic smooth muscle cells (RASMCs). RASMC migration was measured with the Boyden chamber assay, and the result was confirmed with an aortic sprout assay. The activities of kinases were investigated by west...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.fp0070770

    authors： Lee HM,Lee CK,Lee SH,Roh HY,Bae YM,Lee KY,Lim J,Park PJ,Park TK,Lee YL,Won KJ,Kim B

    更新日期：2007-09-01 00:00:00

  • Possible involvement of 5-lipoxygenase metabolite in itch-associated response of mosquito allergy in mice.

    abstract：:This study investigated endogenous mediators involved in mosquito allergy-associated itching in mice. An intradermal injection of an extract of mosquito salivary gland elicited marked scratching in sensitized mice. The 5-lipoxygenase inhibitor zileuton (100 mg/kg), the 5-lipoxygenase activating peptide inhibitor MK-88...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.fp0070404

    authors： Kuraishi Y,Ohtsuka E,Nakano T,Kawai S,Andoh T,Nojima H,Kamimura K

    更新日期：2007-09-01 00:00:00

  • Activation of ERK-p53 and ERK-mediated phosphorylation of Bcl-2 are involved in autophagic cell death induced by the c-Met inhibitor SU11274 in human lung cancer A549 cells.

    abstract：:SU11274, a small molecule inhibitor of c-Met, was reported to induce apoptosis in human non-small-cell lung cancer (NSCLC) cells. However, SU11274-mediated autophagy in NSCLC cells has rarely been reported. The aim of this study was to elucidate the molecular mechanisms mediating SU11274-induced autophagy in NSCLC A54...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.11181fp

    authors： Liu Y,Yang Y,Ye YC,Shi QF,Chai K,Tashiro S,Onodera S,Ikejima T

    更新日期：2012-01-01 00:00:00

  • Discovery of a novel chalcone derivative inhibiting CFTR chloride channel via AMPK activation and its anti-diarrheal application.

    abstract：:Secretory diarrhea is one of the most common causes of death world-wide especially in children under 5 years old. Isoliquiritigenin (ISLQ), a plant-derived chalcone, has previously been shown to exert anti-secretory action in vitro and in vivo by inhibiting CFTR Cl- channels. However, its CFTR inhibition potency is co...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2019.07.012

    authors： Yibcharoenporn C,Chusuth P,Jakakul C,Rungrotmongkol T,Chavasiri W,Muanprasat C

    更新日期：2019-07-01 00:00:00

  • Bladder Contractility Is Mediated by Different K+ Channels in the Urothelium and Detrusor Smooth Muscle.

    abstract：:The roles played by K+ channels in the urothelium (UE) and detrusor smooth muscle (DSM) in regulating agonist-induced bladder contraction is not known at present. Thus, the effects in carbachol (CCh)-induced contraction in UE-intact (+UE) and UE-denuded (-UE) rat detrusor strips pretreated with K+-channel blockers wer...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.10162FP

    authors： Hidayat Santoso AG,Liang W

    更新日期：2011-01-01 00:00:00

  • Antidepressant-like effect of venlafaxine is abolished in μ-opioid receptor-knockout mice.

    abstract：:Although the opioid system is known to modulate depression-like behaviors, its role in the effects of antidepressants is not yet clear. We investigated the role of μ-opioid receptors (MOPs) in the effects of venlafaxine, a serotonin and norepinephrine reuptake inhibitor, in the forced swim test using MOP-knockout (KO)...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.10136sc

    authors： Ide S,Fujiwara S,Fujiwara M,Sora I,Ikeda K,Minami M,Uhl GR,Ishihara K

    更新日期：2010-01-01 00:00:00

  • Antiallodynic action of 1-(3-(9H-Carbazol-9-yl)-1-propyl)-4-(2-methyoxyphenyl)-4-piperidinol (NNC05-2090), a betaine/GABA transporter inhibitor.

    abstract：:The GABAergic system in the spinal cord has been shown to participate in neuropathic pain in various animal models. GABA transporters (GATs) play a role in controlling the synaptic clearance of GABA; however, their role in neuropathic pain remains unclear. In the present study, we compared the betaine/GABA transporter...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.13146fp

    authors： Jinzenji A,Sogawa C,Miyawaki T,Wen XF,Yi D,Ohyama K,Kitayama S,Sogawa N,Morita K

    更新日期：2014-01-01 00:00:00

  • Novel situations of endothelial injury in stroke--mechanisms of stroke and strategy of drug development: novel mechanism of the expression and amplification of cell surface-associated fibrinolytic activity demonstrated by real-time imaging analysis.

    abstract：:Vascular endothelial cells (VECs) secrete tissue plasminogen activator (tPA) in an active form and thus its facilitated secretion directly enhances fibrinolytic activity. We have recently demonstrated its unique secretory dynamics in GFP-tagged tPA expressing VECs using total internal reflection fluorescence microscop...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章,评审

    doi：10.1254/jphs.10r23fm

    authors： Suzuki Y,Urano T

    更新日期：2011-01-01 00:00:00

  • Effects of mosapride citrate, a 5-HT4-receptor agonist, on gastric distension-induced visceromotor response in conscious rats.

    abstract：:Mosapride citrate (mosapride), a prokinetic agent with 5-HT(4)-receptor agonistic activity, is known to enhance gastric emptying and alleviate symptoms in patients with functional dyspepsia (FD). As hyperalgesia and delayed gastric emptying play an important role in the pathogenesis of FD, we used in this study balloo...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.11012fp

    authors： Seto Y,Yoshida N,Kaneko H

    更新日期：2011-01-01 00:00:00

  • Studies on somnolence in the daytime caused by drugs used for neuropathic pain.

    abstract：:In the present study, the characteristics of the sleep features of amitriptyline, mexiletine, and N-(4-tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyradine-1(2H)-carbox-amide (BCTC) were studied. Electrodes were chronically implanted into the frontal cortex and the dorsal neck muscles of rats for electroen...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.08059fp

    authors： Takeda Y,Ishida T,Tsutsui R,Toide K,Tanimoto-Mori S,Watanabe S,Kanai Y,Kamei C

    更新日期：2008-07-01 00:00:00

  • Pharmacological studies on fullerene (C60), a novel carbon allotrope, and its derivatives.

    abstract：:Fullerene (C(60)), a condensed ring aromatic compound with extended pi systems, is a novel carbon allotrope. Because of its poor solubility in polar solvents, investigation of the biological and pharmacological properties of fullerene has been difficult. Recently, water-soluble fullerene derivatives have been synthesi...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章,评审

    doi：10.1254/jphs.cpj06002x

    authors： Satoh M,Takayanagi I

    更新日期：2006-01-01 00:00:00

  • Lack of enhanced effect of antipsychotics combined with fluvoxamine on acetylcholine release in rat prefrontal cortex.

    abstract：:We have shown that coadministration of sulpiride and fluvoxamine preferentially increases the release of dopamine in the prefrontal cortex. To study the possible role of the cortical cholinergic system in this effect, we combined several other antipsychotic drugs with fluvoxamine and examined the effects on acetylchol...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.sc0060187

    authors： Ago Y,Sato M,Nakamura S,Baba A,Matsuda T

    更新日期：2006-12-01 00:00:00

  • Protective effect of baicalin against carbon tetrachloride-induced acute hepatic injury in mice.

    abstract：:This study examined the effects of baicalin, a bioactive flavonoid isolated from Scutellariae Radix, on carbon tetrachloride (CCl(4))-induced liver injury. Mice were treated intraperitoneally with 0.5 ml/kg CCl(4) and different groups of animals received 25, 50, 100, and 200 mg/kg baicalin. At 24 h after the CCl(4) tr...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.fp0071392

    authors： Park SW,Lee CH,Kim YS,Kang SS,Jeon SJ,Son KH,Lee SM

    更新日期：2008-01-01 00:00:00

  • Lifestyle-related diseases of the digestive system: a new in vitro model of hepatitis C virion production: application of basic research on hepatitis C virus to clinical medicine.

    abstract：:The hepatitis C virus (HCV) is an enveloped virus with a single positive-strand RNA genome of about 9.6 kb. It is a major cause of liver disease worldwide. Clear understanding of the viral life cycle has been hampered by the lack of a robust cell culture system. While the development of the HCV replicon system was a m...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章,评审

    doi：10.1254/jphs.fm0070040

    authors： Saito S,Heller T,Yoneda M,Takahashi H,Nakajima A,Liang JT

    更新日期：2007-10-01 00:00:00

  • Functional proteins involved in regulation of intracellular Ca(2+) for drug development: the extracellular calcium receptor and an innovative medical approach to control secondary hyperparathyroidism by calcimimetics.

    abstract：:Circulating levels of calcium ion (Ca(2+)) are maintained within a narrow physiological range mainly by the action of parathyroid hormone (PTH) secreted from parathyroid cells. Parathyroid cells can sense small fluctuations in plasma Ca(2+) levels by virtue of a cell surface Ca(2+) receptor (CaR) that belongs to the s...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章,评审

    doi：10.1254/jphs.fmj04007x6

    authors： Nagano N,Nemeth EF

    更新日期：2005-03-01 00:00:00

  • Specific enhancement of vascular endothelial growth factor (VEGF) production in ischemic region by alprostadil--potential therapeutic application in pharmaceutical regenerative medicine.

    abstract：:Alprostadil (lipo-PGE1) is a drug delivery system preparation. This preparation is applied to treat refractory skin ulcers and arteriosclerosis obliterans. We investigated the effects of alprostadil by using the earflap ischemic model. The following results were obtained: 1) Treatment with alprostadil significantly in...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.13033sc

    authors： Inoue H,Aihara M,Tomioka M,Watabe Y

    更新日期：2013-01-01 00:00:00

  • Intranasal administration of semaphorin-3A alleviates sneezing and nasal rubbing in a murine model of allergic rhinitis.

    abstract：:Sneezing and persistent itching of the nasal mucosa are distressing symptoms of allergic rhinitis (AR). Recent studies have revealed that hyperinnervation of sensory neurons in the nasal turbinate is one of the underlying causes of sneezing and itching. Since Semaphorin-3A (Sema3A) has been previously shown to restric...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.11005fp

    authors： Sawaki H,Nakamura F,Aihara M,Nagashima Y,Komori-Yamaguchi J,Yamashita N,Nakazawa M,Goshima Y,Ikezawa Z

    更新日期：2011-01-01 00:00:00

  • Pharmacology in health foods: effects of arachidonic acid and docosahexaenoic acid on the age-related decline in brain and cardiovascular system function.

    abstract：:Arachidonic acid (ARA) and docosahexaenoic acid (DHA) are major constituents of cell membranes and play important roles in preserving physiological and psychological function. Recently, data from several studies have indicated that impairments in long-term potentiation (LTP), the process underlying plasticity in synap...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章,评审

    doi：10.1254/jphs.10r39fm

    authors： Kiso Y

    更新日期：2011-01-01 00:00:00