当前位置： SCI文献检索 > JOURNAL OF PHARMACOLOGICAL SCIENCES期刊下所有文献 > Diphenidol has no actual broad antiemetic activity in dogs and ferrets.

Diphenidol has no actual broad antiemetic activity in dogs and ferrets.

Abstract：

:Previous studies showed that diphenidol was effective on emetogens-induced pica, eating of non-nutritive substances, in rats, a model analogous to emesis in other species. We evaluated the actual antiemetic activity of diphenidol against four emetic stimuli in the dog and ferret, animals that possess an emetic reflex. In dogs, emetic responses to apomorphine were significantly prevented by diphenidol (3.2 mg/kg, i.v.), whereas diphenidol (3.2 mg/kg, i.v. x 2) showed a weak inhibition to the vomiting evoked by cisplatin. In ferrets, diphenidol (10 mg/kg, i.p.) exhibited a weak antiemetic activity on the emesis induced by copper sulfate and had no activity on emesis by loperamide. On the other hand, CP-122,721, a NK1-receptor antagonist, significantly reduced the emetic episodes to all four stimuli. These results suggest that the prediction of antiemetic activity of compounds in animals lacking an emetic reflex does not always correspond with actual antiemetic activity.

journal_name

J Pharmacol Sci

journal_title

Journal of pharmacological sciences

authors

Nakayama H,Yamakuni H,Nakayama A,Maeda Y,Imazumi K,Matsuo M,Mutoh S

doi

10.1254/jphs.fpj04035x

subject

Has Abstract

pub_date

2004-11-01 00:00:00

pages

301-6

issue

3

eissn

1347-8613

issn

1347-8648

pii

JST.JSTAGE/jphs/FPJ04035X

journal_volume

96

pub_type

杂志文章

相关文献

JOURNAL OF PHARMACOLOGICAL SCIENCES文献大全
  • On the mechanisms underlying histamine induction of gastric mucosal lesions in rats with partial gastric vascular occlusion.

    abstract：:Although it is well known that histamine induces gastric mucosal lesions in laboratory animals, the fundamental mechanisms remain unclear. In order to further analyze the vascular mechanisms underlying histamine-induced lesions, a new model was developed in the glandular stomach via administration of histamine (40 mg/...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.92.124

    authors： Amagase K,Okabe S

    更新日期：2003-06-01 00:00:00

  • Puerarin prevents progression of experimental hypoxia-induced pulmonary hypertension via inhibition of autophagy.

    abstract：:Pulmonary arterial hypertension (PAH) is defined as elevation of mean pulmonary arterial pressure to ≥25 mmHg within the low pressure pulmonary circulatory system. PAH is characterized by obstructive vascular remodeling, partially due to excessive pulmonary arterial smooth muscle cell (PASMC) proliferation. Puerarin i...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2019.09.010

    authors： Zhang X,Liu Q,Zhang C,Sheng J,Li S,Li W,Yang X,Wang X,He S,Bai J,Zhu D

    更新日期：2019-10-01 00:00:00

  • Prolactin levels in schizophrenic patients receiving perospirone in comparison to risperidone.

    abstract：:Serum prolactin levels were investigated in 41 patients with schizophrenia who were receiving clinically effective doses of perospirone or risperidone for more than 4 weeks. In order to determine baseline prolactin levels, blood samples were obtained in the morning, 10 - 14 h after antipsychotic medication. Median lev...

    journal_title：Journal of pharmacological sciences

    pub_type： 临床试验,杂志文章

    doi：10.1254/jphs.91.259

    authors： Togo T,Iseki E,Shoji M,Oyama I,Kase A,Uchikado H,Katsuse O,Kosaka K

    更新日期：2003-03-01 00:00:00

  • Milnacipran affects mouse impulsive, aggressive, and depressive-like behaviors in a distinct dose-dependent manner.

    abstract：:Serotonin/noradrenaline reuptake inhibitors (SNRIs) are widely used for the treatment for major depressive disorder, but these drugs induce several side effects including increased aggression and impulsivity, which are risk factors for substance abuse, criminal involvement, and suicide. To address this issue, milnacip...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2017.06.004

    authors： Tsutsui-Kimura I,Ohmura Y,Yoshida T,Yoshioka M

    更新日期：2017-07-01 00:00:00

  • Changes in blood viscosity with mucopolysaccharide polysulfate.

    abstract：:We examined the dose-dependent effects of mucopolysaccharide polysulfate (MPS) on coagulation variables and whole-blood viscosity in human blood. Both 0.01% and 0.1% MPS significantly reduced levels of both fibrin monomer and thrombin-antithrombin III complex in a manner similar to that of 2.0 IU/ml heparin sodium. Fu...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.95.132

    authors： Hitosugi M,Omura K,Kido M,Kawato H,Niwa M,Nagai T,Tokudome S

    更新日期：2004-05-01 00:00:00

  • Discovery of a novel chalcone derivative inhibiting CFTR chloride channel via AMPK activation and its anti-diarrheal application.

    abstract：:Secretory diarrhea is one of the most common causes of death world-wide especially in children under 5 years old. Isoliquiritigenin (ISLQ), a plant-derived chalcone, has previously been shown to exert anti-secretory action in vitro and in vivo by inhibiting CFTR Cl- channels. However, its CFTR inhibition potency is co...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2019.07.012

    authors： Yibcharoenporn C,Chusuth P,Jakakul C,Rungrotmongkol T,Chavasiri W,Muanprasat C

    更新日期：2019-07-01 00:00:00

  • Neuroprotective DAMPs member prothymosin alpha has additional beneficial actions against cerebral ischemia-induced vascular damages.

    abstract：:Prothymosin alpha (ProTα) suppresses stress-induced necrosis of cultured cortical neurons. As neuroprotection alone could not explain the long-lasting protective actions against cerebral ischemia by ProTα, we further examined whether ProTα, in addition to neuroprotective effects, has other anti-ischemic activities. Wh...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2016.05.006

    authors： Maeda S,Sasaki K,Halder SK,Fujita W,Ueda H

    更新日期：2016-09-01 00:00:00

  • Ameliorative effects of tannic acid on carbon tetrachloride-induced liver fibrosis in vivo and in vitro.

    abstract：:We investigated the ameliorative effects and potential mechanisms of tannic acid (TA) in carbon tetrachloride (CCl4)-intoxicated mice and hepatic stellate cells (HSCs). Liver fibrosis was observed in CCl4 (800 ml/kg)-induced mice, and high viability was observed in CCl4 (10 mM)-intoxicated HSCs. Pre-treatment of mice ...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2015.12.002

    authors： Chu X,Wang H,Jiang YM,Zhang YY,Bao YF,Zhang X,Zhang JP,Guo H,Yang F,Luan YC,Dong YS

    更新日期：2016-01-01 00:00:00

  • Repression of activated aryl hydrocarbon receptor-induced transcriptional activation by 5alpha-dihydrotestosterone in human prostate cancer LNCaP and human breast cancer T47D cells.

    abstract：:Polycyclic aromatic hydrocarbons (PAHs) and dioxins are ubiquitous environmental pollutants and activate the aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor. It has been reported that testosterone represses 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced transcription of the cytochrome P450 (CYP) ...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.08328fp

    authors： Sanada N,Gotoh Y,Shimazawa R,Klinge CM,Kizu R

    更新日期：2009-03-01 00:00:00

  • Activation of ERK-p53 and ERK-mediated phosphorylation of Bcl-2 are involved in autophagic cell death induced by the c-Met inhibitor SU11274 in human lung cancer A549 cells.

    abstract：:SU11274, a small molecule inhibitor of c-Met, was reported to induce apoptosis in human non-small-cell lung cancer (NSCLC) cells. However, SU11274-mediated autophagy in NSCLC cells has rarely been reported. The aim of this study was to elucidate the molecular mechanisms mediating SU11274-induced autophagy in NSCLC A54...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.11181fp

    authors： Liu Y,Yang Y,Ye YC,Shi QF,Chai K,Tashiro S,Onodera S,Ikejima T

    更新日期：2012-01-01 00:00:00

  • Embelin induces apoptosis in human glioma cells through inactivating NF-κB.

    abstract：:Aggressive tumor growth and diffuse tissue invasion are hallmarks of malignant glioma. Embelin is an active compound identified as a novel XIAP inhibitor from the Embelia ribes that exhibits various medicinal effects including anti-inflammatory and anti-cancer activities. In the present study, we investigated whether ...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.12137fp

    authors： Park SY,Lim SL,Jang HJ,Lee JH,Um JY,Kim SH,Ahn KS,Lee SG

    更新日期：2013-01-01 00:00:00

  • Mitochondrial dysfunction, endoplasmic reticulum stress, and apoptosis in Alzheimer's disease.

    abstract：:Alzheimer's disease (AD) is the most common neurodegenerative disorder of late life characterized by insidious, chronic, and progressive memory impairment in association with the accumulation of senile plaques, neurofibrillary tangles, and massive loss of neurons. Apoptosis is believed to be an important contributor t...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章,评审

    doi：10.1254/jphs.cpj04006x

    authors： Takuma K,Yan SS,Stern DM,Yamada K

    更新日期：2005-03-01 00:00:00

  • Establishment of enzyme-linked immunosorbent facilitated antigen binding as a biomarker assay for Japanese cedar pollen allergy immunotherapy.

    abstract：BACKGROUND:Clinical efficacy of allergen-specific Immunotherapy (AIT) towards Japanese cedar (JC) pollen allergy is firmly established but JC pollen-specific biomarker assays are lacking. Treatment-related increase of allergen-specific antibodies is a robust biomarker of successful AIT. Allergen-specific non-IgE antibo...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2019.07.001

    authors： Fukano C,Ohashi-Doi K,Lund K,Nakao A,Masuyama K,Matsuoka T

    更新日期：2019-07-01 00:00:00

  • Caspase mediated enhanced apoptotic action of cyclophosphamide- and resveratrol-treated MCF-7 cells.

    abstract：:Cyclophosphamide (CPA) is a widely used chemotherapeutic drug for neoplasias. It is a DNA and protein alkylating agent having a broad spectrum of activity against a variety of neoplasms including breast cancer. The therapeutic effectiveness of CPA is limited by the high-dose hematopoietic, renal, and cardiac toxicity ...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.08173fp

    authors： Singh N,Nigam M,Ranjan V,Sharma R,Balapure AK,Rath SK

    更新日期：2009-04-01 00:00:00

  • Apelin protects against NMDA-induced retinal neuronal death via an APJ receptor by activating Akt and ERK1/2, and suppressing TNF-α expression in mice.

    abstract：:Glutamate excitotoxicity mediated by N-methyl-d-aspartate (NMDA) receptors is an important cause of retinal ganglion cell death in glaucoma. To elucidate whether apelin protects against retinal neuronal cell death, we examined protective effects of exogenous and endogenous apelin on neuronal cell death induced by intr...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2016.12.002

    authors： Ishimaru Y,Sumino A,Kajioka D,Shibagaki F,Yamamuro A,Yoshioka Y,Maeda S

    更新日期：2017-01-01 00:00:00

  • Expression of cytosolic phospholipase A2 alpha in murine C12 cells, a variant of L929 cells, induces arachidonic acid release in response to phorbol myristate acetate and Ca2+ ionophores, but not to tumor necrosis factor-alpha.

    abstract：:Tumor necrosis factor-alpha (TNFalpha)-induced cell death is regulated through the release of arachidonic acid (AA) by group IVA cytosolic phospholipase A2 (cPLA2alpha) in the murine fibroblast cell line L929. However, the signaling pathway by which TNFalpha activates cPLA2alpha remained to be solved. We examined AA r...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.fpj04033x

    authors： Shimizu M,Azuma C,Taniguchi T,Murayama T

    更新日期：2004-11-01 00:00:00

  • Activation of phosphoinositide 3-kinase, protein kinase C, and extracellular signal-regulated kinase is required for oridonin-enhanced phagocytosis of apoptotic bodies in human macrophage-like U937 cells.

    abstract：:Our previous study showed that oridonin isolated from Rabdosia rubescens enhanced phagocytosis of apoptotic cells by macrophage-like U937 cells through tumor necrosis factor (TNF) alpha and interleukin (IL)-1beta release. In this study, we further investigated signaling events involved in oridonin-augmented phagocytos...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.fpj05005x

    authors： Liu YQ,You S,Tashiro S,Onodera S,Ikejima T

    更新日期：2005-08-01 00:00:00

  • The role of muscarinic receptor subtypes on carbachol-induced contraction of normal human detrusor and overactive detrusor associated with benign prostatic hyperplasia.

    abstract：:The aim of this study was to compare the effect of antimuscarinic antagonists on carbachol-induced contraction of normal human bladder and detrusor overactivity associated with benign prostatic hyperplasia (DO/BPH). Samples of human bladder muscle were obtained from patients undergoing total cystectomy for bladder can...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2015.05.005

    authors： Yamanishi T,Kaga K,Fuse M,Shibata C,Kamai T,Uchiyama T

    更新日期：2015-06-01 00:00:00

  • Possible role of nitric oxide in anxiety following transient cerebral ischemia in mice.

    abstract：:The possible role of nitric oxide (NO) in anxiety following transient cerebral ischemia by a 10-min bilateral carotid occlusion was examined in mice. Two days after the ischemia, mice showed a significant decrease in time spent on the open arms in the elevated plus-maze test; and likewise, they showed shortened social...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.91.47

    authors： Nakashima MN,Ajiki K,Nakashima K,Takahashi M

    更新日期：2003-01-01 00:00:00

  • Interactions of human organic anion transporters with aristolochic acids.

    abstract：:Aristolochic acids (AAs), contained in Chinese herbal preparations, have been considered to induce nephropathy. In order to elucidate the molecular mechanisms of AA-induced nephrotoxicity, we have elucidated the interaction of human organic anion transporters (hOATs) with AAs using their stable cell lines. AA-I and AA...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.09339sc

    authors： Babu E,Takeda M,Nishida R,Noshiro-Kofuji R,Yoshida M,Ueda S,Fukutomi T,Anzai N,Endou H

    更新日期：2010-01-01 00:00:00

  • Administration of xenobiotics with anti-estrogenic effects results in mRNA induction of adult male-specific cytochrome P450 isozymes in the livers of adult female rats.

    abstract：:Cytochrome P450 (CYP) catalyzes the oxidation of many endogenous and xenobiotic compounds. The expression of CYP isozymes are modulated by endogenous hormones and xenobiotics. We found that, although CYP2C11 and CYP3A2 are adult male-specific isozymes, they are also expressed in prepubertal female Sprague Dawley (SD) ...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.fp0060414

    authors： Ishii T,Nishimura K,Nishimura M

    更新日期：2006-07-01 00:00:00

  • Possible involvement of endogenous opioid system located downstream of α7 nicotinic acetylcholine receptor in mice with physical dependence on nicotine.

    abstract：:We previously reported that nicotine (NIC)-induced analgesia was elicited in part by activation of the endogenous opioid system. Moreover, it is well known that NIC has physical-dependence liability, but its mechanism is unclear. Therefore, we examined whether physical dependence on NIC was mediated by activation of t...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.13172fp

    authors： Ueno K,Kiguchi N,Kobayashi Y,Saika F,Wakida N,Yamamoto C,Maeda T,Ozaki M,Kishioka S

    更新日期：2014-01-01 00:00:00

  • Simvastatin, an HMG-CoA reductase inhibitor, reduced the expression of matrix metalloproteinase-9 (Gelatinase B) in osteoblastic cells and HT1080 fibrosarcoma cells.

    abstract：:MMP-9 or Gelatinase B, a member of the matrix metalloproteinase family (MMPs), plays important roles in physiological events such as tissue remodeling and in pathological processes that lead to destructive bone diseases, including osteoarthritis and periodontitis. In addition to its effect on the increase of total bon...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.94.403

    authors： Thunyakitpisal PD,Chaisuparat R

    更新日期：2004-04-01 00:00:00

  • Effects of mannitol on ischemia-induced degeneration in rat hippocampus.

    abstract：:Although mannitol has been used as an osmotherapeutic drug on brain injury, the clinical efficiency of the drug are still controversial. In the present study, we examined the effects of mannitol on the edema in a hippocampal slice due to brief ischemia. To evaluate the effects, we employed an image analysis system tha...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.fp0030565

    authors： Nakajima R,Nakamura T,Miyakawa H,Kudo Y

    更新日期：2004-07-01 00:00:00

  • Chronopharmacology of angiotensin II-receptor blockers in stroke-prone spontaneously hypertensive rats.

    abstract：:Protective effect of valsartan (Val), an angiotensin II (AII)-receptor blocker (ARB), against organ damage is reported to depend on the dosing time in hypertensive patients. Dosing-time-dependent effect of Val on survival of stroke-prone spontaneously hypertensive rats (SHRSP) under a 12-h lighting cycle was examined....

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.10284fp

    authors： Liu Y,Ushijima K,Ohmori M,Takada M,Tateishi M,Ando H,Fujimura A

    更新日期：2011-01-01 00:00:00

  • Interaction between anti-Alzheimer and antipsychotic drugs in modulating extrapyramidal motor disorders in mice.

    abstract：:Antipsychotics are often used in conjunction with anti-Alzheimer drugs to treat the behavioral and psychological symptoms of dementia (BPSD). Here, we examined the effects of cholinesterase inhibitors (ChEIs), donepezil and galantamine, on antipsychotic-induced extrapyramidal side effects (EPS) in mice. The effects of...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2015.03.004

    authors： Shimizu S,Mizuguchi Y,Sobue A,Fujiwara M,Morimoto T,Ohno Y

    更新日期：2015-04-01 00:00:00

  • Characterization and comparison of sodium-glucose cotransporter 2 inhibitors in pharmacokinetics, pharmacodynamics, and pharmacologic effects.

    abstract：:The sodium-glucose cotransporter (SGLT) 2 offer a novel approach to treating type 2 diabetes by reducing hyperglycaemia via increased urinary glucose excretion. In the present study, the pharmacokinetic, pharmacodynamic, and pharmacologic properties of all six SGLT2 inhibitors commercially available in Japan were inve...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2016.02.003

    authors： Tahara A,Takasu T,Yokono M,Imamura M,Kurosaki E

    更新日期：2016-03-01 00:00:00

  • Paeoniflorin selectively inhibits LPS-provoked B-cell function.

    abstract：:B cells are important in the development of autoimmune disorders through mechanisms involving dysregulated polyclonal B-cell activation, production of pathogenic antibodies, and targeting which reduces inflammation and tissue damage effectively but often leads to patients suffering from secondary infection. Paeoniflor...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2015.02.011

    authors： Zhang J,Li H,Huo R,Zhai T,Li H,Sun Y,Shen B,Li N

    更新日期：2015-05-01 00:00:00

  • Heterotrimeric G protein G alpha13-induced induction of cytokine mRNAs through two distinct pathways in cardiac fibroblasts.

    abstract：:Overexpression of constitutively active (CA)-G alpha13 significantly increased the expression of interleukin (IL)-1beta and IL-6 mRNAs and proteins in rat cardiac fibroblasts. IL-1beta mRNA induction by CA-G alpha13 was suppressed by diphenyleneiodonium (DPI), an NADPH oxidase inhibitor, but not by BAPTA-AM, an intrac...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.fp0051036

    authors： Nagamatsu Y,Nishida M,Onohara N,Fukutomi M,Maruyama Y,Kobayashi H,Sato Y,Kurose H

    更新日期：2006-06-01 00:00:00

  • Effects of metformin on proliferation and apoptosis of human megakaryoblastic Dami and MEG-01 cells.

    abstract：:Metformin has received increasing attention for its potential anticancer activity against certain human leukemia cells, but its effects on human megakaryoblastic cells are unclear. This study aimed to investigate the effects of metformin on proliferation and apoptosis of human megakaryoblastic cells (Dami and MEG-01) ...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2017.08.003

    authors： Liang X,Kong P,Wang J,Xu Y,Gao C,Guo G

    更新日期：2017-09-01 00:00:00