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Mitochondrial dysfunction, endoplasmic reticulum stress, and apoptosis in Alzheimer's disease.

Abstract：

:Alzheimer's disease (AD) is the most common neurodegenerative disorder of late life characterized by insidious, chronic, and progressive memory impairment in association with the accumulation of senile plaques, neurofibrillary tangles, and massive loss of neurons. Apoptosis is believed to be an important contributor to progression and pathology of neurodegeneration in AD. There is considerable evidence that amyloid beta-peptide, a major component of senile plaques, has the capacity to activate intracellular apoptosis pathways leading to neuronal cell death. AD-related mutations in genes coding presenilins are also shown to cause neuronal apoptosis, by directly and indirectly regulating apoptotic signaling cascades. Recent evidence suggests that two intrinsic pathways, mitochondrial dysfunction and endoplasmic reticulum stress, are central in the execution of apoptosis in AD. This review summarizes recent progress of research in this field focused on the molecular mechanisms involved in neuronal apoptosis mediated by organelle dysfunction.

journal_name

J Pharmacol Sci

journal_title

Journal of pharmacological sciences

authors

Takuma K,Yan SS,Stern DM,Yamada K

doi

10.1254/jphs.cpj04006x

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

312-6

issue

3

eissn

1347-8613

issn

1347-8648

pii

JST.JSTAGE/jphs/CPJ04006X

journal_volume

97

pub_type

杂志文章,评审

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