Forced exercise-induced flushing of tail skin in ovariectomized mice, as a new experimental model of menopausal hot flushes.

abstract：:Pseudolaric acid B (PAB) exerted cytostatic activity on murine fibrosarcoma L929 cells. The cytostatic mechanism of PAB on L929 cells was investigated in this paper. At 36 h, after 80 microM PAB treatment, the inhibitory ratio was 65.37 +/- 4.12%, and the MDC staining ratio was strongest in L929 cells. 3-Methyladenine...

journal_title：Journal of pharmacological sciences

authors： Yu J,Li X,Tashiro S,Onodera S,Ikejima T

更新日期：2008-07-01 00:00:00

abstract：:We investigated the participation of gamma-aminobutyric acid (GABA) neurons of the medial septal area in eight-arm radial maze performance in rats. The intra-septal injection of muscimol, a GABA(A) agonist, caused an increase in total error and working memory error. On the other hand, no significant effect was observe...

journal_title：Journal of pharmacological sciences

authors： Yamamoto Y,Mikami A,Fujii Y,Kamei C

更新日期：2007-07-01 00:00:00

abstract：:Antagonism of the dopamine D3 receptor has been hypothesized to be beneficial for schizophrenia cognitive deficits, negative symptoms and extrapyramidal symptoms. However, recent animal and human studies have shown that most antipsychotics do not occupy D3 receptors in vivo, despite their considerable binding affinity...

journal_title：Journal of pharmacological sciences

authors： Baba S,Enomoto T,Horisawa T,Hashimoto T,Ono M

更新日期：2015-03-01 00:00:00

abstract：:We investigated the anti-vasospastic potential of fasudil's active metabolite, hydroxyfasudil, a Rho-kinase inhibitor, after subarachnoid hemorrhage (SAH) and also its effect on hemorheological abnormalities following cerebral ischemia. Chronic cerebral vasospasm was produced using a two-hemorrhage canine model. On da...

journal_title：Journal of pharmacological sciences

authors： Satoh S,Takayasu M,Kawasaki K,Ikegaki I,Hitomi A,Yano K,Shibuya M,Asano T

更新日期：2012-01-01 00:00:00

abstract：:The distribution of group I metabotropic glutamate receptors in rat hippocampal cells in culture was examined by calcium imaging and immunocytochemistry. To distinguish different cell types in the culture, the effects of t-ACPD ((1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid) and of NMDA (N-methyl-D-aspartate) were...

journal_title：Journal of pharmacological sciences

authors： Yoshida Y,Matsumoto N,Tsuchiya R,Morita M,Miyakawa H,Kudo Y

更新日期：2003-07-01 00:00:00

abstract：:Bee venom (BV) has been used in patients with rheumatoid arthritis, a condition characterized by rheumatoid joint destruction mediated, in large part, by matrix metalloproteinases (MMPs). We investigated the effects of melittin, a major component of bee venom, on the production of MMPs in human rheumatoid arthritic fi...

journal_title：Journal of pharmacological sciences

authors： Nah SS,Ha E,Mun SH,Won HJ,Chung JH

更新日期：2008-01-01 00:00:00

abstract：:Melittin is a major peptide component of sweet bee venom that possesses anti-allergic, anti-inflammatory, anti-arthritis, anti-cancer, and neuroprotective properties. However, the therapeutic effects of melittin on muscle injury have not been elucidated. We investigated the therapeutic effects of melittin on muscle in...

journal_title：Journal of pharmacological sciences

authors： Lee JE,Shah VK,Lee EJ,Oh MS,Choi JJ

更新日期：2019-05-01 00:00:00

abstract：:G protein-coupled receptors, in particular, Ca(2+)-mobilizing G(q)-coupled receptors have been reported to be targets for anesthetics. Opioids are commonly used analgesics in clinical practice, but the effects of anesthetics on the opioid mu-receptors (muOR) have not been systematically examined. We report here an ele...

journal_title：Journal of pharmacological sciences

authors： Minami K,Sudo Y,Shiraishi S,Seo M,Uezono Y

更新日期：2010-01-01 00:00:00

abstract：:We recently reported that physiological concentrations of 17beta-estradiol partially down-regulate cardiac rapidly-activating delayed rectifier K(+) currents (hERG currents) independently of estrogen-receptor signaling. To determine if other estrogens have the same effect as that of 17beta-estradiol, we investigated r...

journal_title：Journal of pharmacological sciences

authors： Kakusaka S,Asayama M,Kaihara A,Sasano T,Suzuki T,Kurokawa J,Furukawa T

更新日期：2009-01-01 00:00:00

abstract：:The supraspinal and spinal antinociceptive effects of several kappa-opioid receptor agonists were examined in diabetic and non-diabetic mice using the tail-flick assay. The antinociception induced by intrathecal (i.t.), but not intracerebroventricular (i.c.v.), CI-977, a highly selective kappa(1)-opioid receptor agoni...

journal_title：Journal of pharmacological sciences

authors： Ohsawa M,Kamei J

更新日期：2005-05-01 00:00:00

abstract：:Ischemia/reperfusion (I/R)-induced oxidative stress is a serious clinical problem in the reperfusion therapy for ischemic diseases. Tumstatin is an endogenous bioactive peptide cleaved from type IV collagen α3 chain. We previously reported that T3 peptide, an active subfragment of tumstatin, exerts cytoprotective effe...

journal_title：Journal of pharmacological sciences

authors： Yasuda J,Okada M,Yamawaki H

更新日期：2019-03-01 00:00:00

abstract：:The extracellular L-glutamate (L-Glu) concentration is elevated in neuroinflammation, thereby causing excitotoxicity. One of the mechanisms is down-regulation of astrocyte L-Glu transporters. Some antidepressants have anti-inflammatory effects. We therefore investigated effects of various antidepressants on the down-r...

journal_title：Journal of pharmacological sciences

authors： Fujimori K,Takaki J,Shigemoto-Mogami Y,Sekino Y,Suzuki T,Sato K

更新日期：2015-01-01 00:00:00

abstract：:We examined the dose-dependent effects of mucopolysaccharide polysulfate (MPS) on coagulation variables and whole-blood viscosity in human blood. Both 0.01% and 0.1% MPS significantly reduced levels of both fibrin monomer and thrombin-antithrombin III complex in a manner similar to that of 2.0 IU/ml heparin sodium. Fu...

journal_title：Journal of pharmacological sciences

authors： Hitosugi M,Omura K,Kido M,Kawato H,Niwa M,Nagai T,Tokudome S

更新日期：2004-05-01 00:00:00

abstract：:Cardiovascular diseases are the most frequent and costly complication of diabetes. Many previous studies showed that ATP-sensitive potassium channels (K(ATP)) and inward rectifier potassium channels (Kir) play important regulatory roles in functions of cardiovascular tissues. It's still not very clear how these potass...

journal_title：Journal of pharmacological sciences

authors： Ren Y,Xu X,Wang X

更新日期：2003-12-01 00:00:00

abstract：:Microglia are macrophage-like phagocytic cells in the brain parenchyma. However, microglial function after neurodegeneration is not fully understood. In this study, occlusion of the middle cerebral artery (MCA) and reperfusion caused massive neuronal loss in the rat cerebral cortex and striatum after 3 days. When exog...

journal_title：Journal of pharmacological sciences

authors： Kitamura Y,Takata K,Inden M,Tsuchiya D,Yanagisawa D,Nakata J,Taniguchi T

更新日期：2004-02-01 00:00:00

abstract：:Polyriboinosinic-polyribocytidilic acid (polyI:C) is a synthetic analog that elicits viral-like immune responses in mammals. We have recently found that polyI:C treatment in neonatal mice induced abnormalities of emotional, cognitive, and sensorimotor gating and dysfunction of glutamatergic neurotransmission in adulth...

journal_title：Journal of pharmacological sciences

authors： Nagai T,Yu J,Kitahara Y,Nabeshima T,Yamada K

更新日期：2012-01-01 00:00:00

abstract：:Isolation-induced abnormal behaviors are useful animal models for assessing potential anti-psychotic drugs. This study examined the effect of MGS0028, a selective metabotropic glutamate 2/3 receptor agonist, on abnormal behaviors such as hyperactivity, aggression, and deficits of prepulse inhibition in isolation-reare...

journal_title：Journal of pharmacological sciences

authors： Ago Y,Araki R,Yano K,Kawasaki T,Chaki S,Nakazato A,Onoe H,Hashimoto H,Baba A,Takuma K,Matsuda T

更新日期：2012-01-01 00:00:00

abstract：:To elucidate the mechanism of action of prostaglandin I(2) (PGI(2)) and carbaprostacyclin, we studied their effect on DNA synthesis and proliferation in primary cultures of adult rat hepatocytes. Hepatocyte parenchymal cells, maintained in a serum-free, defined medium, synthesized DNA and proliferated in the presence ...

journal_title：Journal of pharmacological sciences

authors： Kimura M,Okamoto H,Natsume H,Ogihara M

更新日期：2009-04-01 00:00:00

abstract：:Antihistamines inhibit histamine signaling by blocking histamine H1 receptor (H1R) or suppressing H1R signaling as inverse agonists. The H1R gene is upregulated in patients with pollinosis, and its expression level is correlated with the severity of nasal symptoms. Here, we show that antihistamine suppressed upregulat...

journal_title：Journal of pharmacological sciences

authors： Mizuguchi H,Das AK,Maeyama K,Dev S,Shahriar M,Kitamura Y,Takeda N,Fukui H

更新日期：2016-04-01 00:00:00

abstract：:Cytochrome P450 (CYP)-mediated drug interactions caused by Kampo medicine have not been investigated sufficiently. The current study was conducted to reveal the effect of anchusan, a commonly used Kampo formula for gastrointestinal disease, on CYP3A-mediated drug metabolism in rats. The pharmacokinetics of midazolam (...

journal_title：Journal of pharmacological sciences

authors： Saito Y,Nishimura Y,Kurata N,Iwase M,Aoki K,Yasuhara H

更新日期：2011-01-01 00:00:00

abstract：:In the present study, the characteristics of the sleep features of amitriptyline, mexiletine, and N-(4-tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyradine-1(2H)-carbox-amide (BCTC) were studied. Electrodes were chronically implanted into the frontal cortex and the dorsal neck muscles of rats for electroen...

journal_title：Journal of pharmacological sciences

authors： Takeda Y,Ishida T,Tsutsui R,Toide K,Tanimoto-Mori S,Watanabe S,Kanai Y,Kamei C

更新日期：2008-07-01 00:00:00

abstract：:IAP antagonists increased the antitumor efficacy of X-irradiation in some types of cancers, but their effects on hypoxic cancer cells remain unclarified. We aims to investigate the radiosensitizing effect of an IAP inhibitor AT-406 on cervical cancer cell lines under both normoxia and hypoxia conditions. Hela and Siha...

journal_title：Journal of pharmacological sciences

authors： Lu J,Qin Q,Zhan LL,Liu J,Zhu HC,Yang X,Zhang C,Xu LP,Liu ZM,Wang D,Cui HQ,Meng CC,Cai J,Cheng HY,Sun XC

更新日期：2014-01-01 00:00:00

abstract：:The role of nitric oxide (NO) in the changes in enterochromaffin cells and ileal 5-hydroxytryptamine (5-HT) content induced by a single i.p. administration of methotrexate was investigated in rats. Methotrexate significantly increased inducible NO synthase (iNOS) mRNA and protein expressions in the intestinal tissue a...

journal_title：Journal of pharmacological sciences

authors： Takano Y,Hirano M,Machida T,Obara Y,Hamaue N,Fujita K,Taniguchi M,Endo T,Shiga S,Machida M,Iizuka K,Hirafuji M

更新日期：2019-09-01 00:00:00

abstract：:Androgen-independent prostate cancer (PCa) is a developed tumor derived from the local androgen dependent PCa, which often affects elderly men. Psoralea corylifolia L, a traditional Chinese medicine, has been widely used for PCa treatment as an important part of a common prescription, while the mechanism remains uncle...

journal_title：Journal of pharmacological sciences

authors： Miao L,Yun X,Tao R,Wang Y,Fan G,Zhu Y,Cai T,Zhu Z,Yan C,Gao X

更新日期：2018-09-01 00:00:00

abstract：:It has been widely accepted that macrophages are divided into M1 "pro-inflammatory" macrophages and M2 "anti-inflammatory" macrophages and an uncontrolled macrophage polarization plays an important role in the pathogenesis of different diseases. As the main substance of total glucosides of peony, paeoniflorin (PF), ha...

journal_title：Journal of pharmacological sciences

authors： Zhai T,Sun Y,Li H,Zhang J,Huo R,Li H,Shen B,Li N

更新日期：2016-03-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPARgamma) is a ligand-dependent nuclear receptor and regulates adipogenesis and fat metabolism. PPARgamma is activated by fatty acid derivatives and some synthetic compounds such as the thiazolidinediones. In addition, certain cytokines were known to affect the transa...

journal_title：Journal of pharmacological sciences

authors： Takada I,Suzawa M,Kato S

更新日期：2005-02-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a group of small noncoding RNAs that regulate translational repression of multiple target mRNAs. The miRNAs in a whole cell regulate greater than 30% of all protein-coding genes. The vast majority of presently identified miRNAs are expressed in the brain in a spatially and temporally controlled ...

journal_title：Journal of pharmacological sciences

authors： Satoh J

更新日期：2010-01-01 00:00:00

abstract：:L-Dihydroxyphenylalanine (L-DOPA) is considered the gold standard for the treatment of Parkinson's disease (PD). However, long-term administration of L-DOPA can induce abnormal side effects. On the other hand, selective serotonin reuptake inhibitors (SSRIs) including fluoxetine have gained tremendous popularity in the...

journal_title：Journal of pharmacological sciences

authors： Inden M,Abe M,Minamino H,Takata K,Yoshimoto K,Tooyama I,Kitamura Y

更新日期：2012-01-01 00:00:00

abstract：:The role of extracellular calcium in the interaction between intracellular cAMP and nitric oxide (NO)/cGMP on the contractility of rat diaphragm pretreated with cumulative concentrations of aminophylline (0.36 - 3.60 mM) was investigated. In a Ca2+-free medium, NG-nitro-L-arginine methyl ester (L-NAME) (1 and 3 mM) de...

journal_title：Journal of pharmacological sciences

authors： Stojanovic R,Todorović Z,Nesić Z,Vućković S,Cerovac-Cosić N,Prostran M

更新日期：2004-12-01 00:00:00

abstract：:In this study, we provide evidence of critical changes in the expression of non-selective cation currents (NSCC) during culture in rat aortic myocytes. A selective TRPV4 agonist, 4alpha-phorbol 12,13-didecanoate (4alphaPDD), had little effect on membrane currents and intracellular Ca(2+) (Ca(2+)(i)) in freshly isolate...

journal_title：Journal of pharmacological sciences

authors： Tanaka R,Muraki K,Ohya S,Yamamura H,Hatano N,Itoh Y,Imaizumi Y

更新日期：2008-10-01 00:00:00