Abstract:
:We examined the dose-dependent effects of mucopolysaccharide polysulfate (MPS) on coagulation variables and whole-blood viscosity in human blood. Both 0.01% and 0.1% MPS significantly reduced levels of both fibrin monomer and thrombin-antithrombin III complex in a manner similar to that of 2.0 IU/ml heparin sodium. Furthermore, MPS dose-dependently decreased whole-blood viscosity, as measured with an oscillation viscometer. Because MPS can be applied in creams and gels, percutaneous application of MPS may effectively reduce whole-blood viscosity in local veins.
journal_name
J Pharmacol Scijournal_title
Journal of pharmacological sciencesauthors
Hitosugi M,Omura K,Kido M,Kawato H,Niwa M,Nagai T,Tokudome Sdoi
10.1254/jphs.95.132subject
Has Abstractpub_date
2004-05-01 00:00:00pages
132-4issue
1eissn
1347-8613issn
1347-8648journal_volume
95pub_type
杂志文章abstract::Since induced pluripotent stem cells (iPSCs) were generated from mice and humans by Professor Shinya Yamanaka et al. in 2006 and 2007, respectively, a variety of human-derived cells have been generated, including myocardial, liver, retinal pigment epithelial, and neuronal cells. These iPSCs are now used not only in cl...
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更新日期:2012-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2010-01-01 00:00:00
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journal_title:Journal of pharmacological sciences
pub_type: 杂志文章
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abstract::The supraspinal and spinal antinociceptive effects of several kappa-opioid receptor agonists were examined in diabetic and non-diabetic mice using the tail-flick assay. The antinociception induced by intrathecal (i.t.), but not intracerebroventricular (i.c.v.), CI-977, a highly selective kappa(1)-opioid receptor agoni...
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journal_title:Journal of pharmacological sciences
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Journal of pharmacological sciences
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