Abstract:
:We investigated the participation of gamma-aminobutyric acid (GABA) neurons of the medial septal area in eight-arm radial maze performance in rats. The intra-septal injection of muscimol, a GABA(A) agonist, caused an increase in total error and working memory error. On the other hand, no significant effect was observed with reference memory error. Donepezil and tacrine (cholinesterase inhibitors) antagonized the muscimol-induced spatial memory deficits. Histidine (1500 mg/kg, i.p.) also improved the total error and working memory error induced by muscimol. At this dose, histidine caused a significant increase in the histamine content of the cortex, hippocampus, and hypothalamus in rats. In addition, the intra-hippocampal injection of histamine also antagonized muscimol-induced spatial memory deficits. The practical conclusion is that the GABA(A) receptor of the medial septal area plays an important role in working memory, and also, the disturbance of working memory induced by muscimol is mediated not only by cholinergic but also by histaminergic systems in the spatial memory of rats.
journal_name
J Pharmacol Scijournal_title
Journal of pharmacological sciencesauthors
Yamamoto Y,Mikami A,Fujii Y,Kamei Cdoi
10.1254/jphs.fp0061472subject
Has Abstractpub_date
2007-07-01 00:00:00pages
252-7issue
3eissn
1347-8613issn
1347-8648pii
JST.JSTAGE/jphs/FP0061472journal_volume
104pub_type
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