Abstract:
:To explore memory enhancing effect of the flavonoid fisetin, we investigated the effect of oral administration of flavonoids on the induction of long-term potentiation (LTP) at hippocampal CA1 synapses of anesthetized rats. Among four flavonoids (fisetin, quercetin, luteolin and myricetin) tested, only fisetin significantly facilitated the induction of hippocampal LTP. The effect of oral fisetin was abolished by intracerebroventricular injection of U0126, an agent that was previously found to inhibit its effect in hippocampal slices in vitro. These results suggest that orally administered fisetin crosses the blood-brain barrier and promotes synaptic functions in the hippocampus.
journal_name
J Pharmacol Scijournal_title
Journal of pharmacological sciencesauthors
He WB,Abe K,Akaishi Tdoi
10.1016/j.jphs.2017.12.008subject
Has Abstractpub_date
2018-01-01 00:00:00pages
42-45issue
1eissn
1347-8613issn
1347-8648pii
S1347-8613(17)30211-6journal_volume
136pub_type
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