Abstract:
:Nicotine inhibited interleukin (IL)-18 and -12 production in lipopolysaccharide (LPS)-stimulated monocytes, and the action of nicotine was antagonized by a non-selective and a selective alpha7 nicotinic acetylcholine receptor (alpha7-nAChR) antagonist, suggesting that the stimulation of alpha7-nAChR may be involved in the action of nicotine. Nicotine is reported to induce prostaglandin E(2) (PGE(2)) production in monocytes through the up-regulation of cyclooxygenase (COX)-2 expression. PGE(2) is known to increase cAMP levels and to activate protein kinase A (PKA). COX-2 and PKA inhibitors prevented the action of nicotine, indicating that the mechanism of action of nicotine may be via endogenous PGE(2) production.
journal_name
J Pharmacol Scijournal_title
Journal of pharmacological sciencesauthors
Takahashi HK,Iwagaki H,Hamano R,Yoshino T,Tanaka N,Nishibori Mdoi
10.1254/jphs.sc0060074subject
Has Abstractpub_date
2006-09-01 00:00:00pages
143-6issue
1eissn
1347-8613issn
1347-8648pii
JST.JSTAGE/jphs/SC0060074journal_volume
102pub_type
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