Prolactin levels in schizophrenic patients receiving perospirone in comparison to risperidone.

abstract：:Kv1.5 is considered to be a potential molecular target for treatment of atrial fibrillation or flutter. Disopyramide is widely used in the treatment of atrial flutter and/or atrial fibrillation. The present study was undertaken to characterize the effects of disopyramide on currents mediated by Kv1.5 channels and to d...

journal_title：Journal of pharmacological sciences

authors： Aréchiga IA,Barrio-Echavarria GF,Rodríguez-Menchaca AA,Moreno-Galindo EG,Decher N,Tristani-Firouzi M,Sánchez-Chapula JA,Navarro-Polanco RA

更新日期：2008-09-01 00:00:00

abstract：:Isolation-induced abnormal behaviors are useful animal models for assessing potential anti-psychotic drugs. This study examined the effect of MGS0028, a selective metabotropic glutamate 2/3 receptor agonist, on abnormal behaviors such as hyperactivity, aggression, and deficits of prepulse inhibition in isolation-reare...

journal_title：Journal of pharmacological sciences

authors： Ago Y,Araki R,Yano K,Kawasaki T,Chaki S,Nakazato A,Onoe H,Hashimoto H,Baba A,Takuma K,Matsuda T

更新日期：2012-01-01 00:00:00

abstract：:Protective effect of valsartan (Val), an angiotensin II (AII)-receptor blocker (ARB), against organ damage is reported to depend on the dosing time in hypertensive patients. Dosing-time-dependent effect of Val on survival of stroke-prone spontaneously hypertensive rats (SHRSP) under a 12-h lighting cycle was examined....

journal_title：Journal of pharmacological sciences

authors： Liu Y,Ushijima K,Ohmori M,Takada M,Tateishi M,Ando H,Fujimura A

更新日期：2011-01-01 00:00:00

abstract：:The possible role of nitric oxide (NO) in anxiety following transient cerebral ischemia by a 10-min bilateral carotid occlusion was examined in mice. Two days after the ischemia, mice showed a significant decrease in time spent on the open arms in the elevated plus-maze test; and likewise, they showed shortened social...

journal_title：Journal of pharmacological sciences

authors： Nakashima MN,Ajiki K,Nakashima K,Takahashi M

更新日期：2003-01-01 00:00:00

abstract：:To investigate the effect of cis-N-[4-[4-(1,2-benz-isozole-3-yl)-1-piperazinyl]butyl] cyclohexane-1,2-dicarboximide hydrochloride (perospirone), a novel antipsychotic agent with high affinities for D(2)/5-HT(2) receptors, on the rat dorsal raphe (DR) neurons, an electrophysiological study was performed using the tight...

journal_title：Journal of pharmacological sciences

authors： Shiwa T,Amano T,Matsubayashi H,Seki T,Sasa M,Sakai N

更新日期：2003-09-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common neurodegenerative disorder of late life characterized by insidious, chronic, and progressive memory impairment in association with the accumulation of senile plaques, neurofibrillary tangles, and massive loss of neurons. Apoptosis is believed to be an important contributor t...

journal_title：Journal of pharmacological sciences

authors： Takuma K,Yan SS,Stern DM,Yamada K

更新日期：2005-03-01 00:00:00

abstract：:Cardiovascular diseases are the most frequent and costly complication of diabetes. Many previous studies showed that ATP-sensitive potassium channels (K(ATP)) and inward rectifier potassium channels (Kir) play important regulatory roles in functions of cardiovascular tissues. It's still not very clear how these potass...

journal_title：Journal of pharmacological sciences

authors： Ren Y,Xu X,Wang X

更新日期：2003-12-01 00:00:00

abstract：:Effects of V(1) (OPC-21268) and V(2) (OPC-31260) vasopressin antagonists on blood pressure (BP) short-term variability were investigated in adult spontaneously hypertensive rats (SHR) under basal conditions and after the stimulation of vasopressin release by hemorrhage. BP was recorded intra-arterially and sampled at ...

journal_title：Journal of pharmacological sciences

authors： Japundzić-Zigon N,Milutinović S,Jovanović A

更新日期：2004-05-01 00:00:00

abstract：:We examined the dose-dependent effects of mucopolysaccharide polysulfate (MPS) on coagulation variables and whole-blood viscosity in human blood. Both 0.01% and 0.1% MPS significantly reduced levels of both fibrin monomer and thrombin-antithrombin III complex in a manner similar to that of 2.0 IU/ml heparin sodium. Fu...

journal_title：Journal of pharmacological sciences

authors： Hitosugi M,Omura K,Kido M,Kawato H,Niwa M,Nagai T,Tokudome S

更新日期：2004-05-01 00:00:00

abstract：:To investigate whether miniature pigs are useful for evaluating the potential of drugs for drug-induced prolongation of the QT interval, we performed an in vivo QT assay using conscious and unrestricted miniature pigs. Compared with the vehicle average baseline values, haloperidol at 3 and 10 mg/kg, p.o. prolonged the...

journal_title：Journal of pharmacological sciences

authors： Kano M,Toyoshi T,Iwasaki S,Kato M,Shimizu M,Ota T

更新日期：2005-01-01 00:00:00

abstract：:AMP-activated protein kinase (AMPK) contributes to the acceleration of insulin signaling. However, the mechanism by which AMPK regulates insulin signaling remains unclear. Serine phosphorylation of insulin receptor substrate (IRS)-1 negatively regulates insulin signaling. Here we investigated the role of AMPK in serin...

journal_title：Journal of pharmacological sciences

authors： Shibata T,Takaguri A,Ichihara K,Satoh K

更新日期：2013-01-01 00:00:00

abstract：:We investigated the anti-vasospastic potential of fasudil's active metabolite, hydroxyfasudil, a Rho-kinase inhibitor, after subarachnoid hemorrhage (SAH) and also its effect on hemorheological abnormalities following cerebral ischemia. Chronic cerebral vasospasm was produced using a two-hemorrhage canine model. On da...

journal_title：Journal of pharmacological sciences

authors： Satoh S,Takayasu M,Kawasaki K,Ikegaki I,Hitomi A,Yano K,Shibuya M,Asano T

更新日期：2012-01-01 00:00:00

abstract：:MMP-9 or Gelatinase B, a member of the matrix metalloproteinase family (MMPs), plays important roles in physiological events such as tissue remodeling and in pathological processes that lead to destructive bone diseases, including osteoarthritis and periodontitis. In addition to its effect on the increase of total bon...

journal_title：Journal of pharmacological sciences

authors： Thunyakitpisal PD,Chaisuparat R

更新日期：2004-04-01 00:00:00

abstract：:Vascular endothelial cells (VECs) secrete tissue plasminogen activator (tPA) in an active form and thus its facilitated secretion directly enhances fibrinolytic activity. We have recently demonstrated its unique secretory dynamics in GFP-tagged tPA expressing VECs using total internal reflection fluorescence microscop...

journal_title：Journal of pharmacological sciences

authors： Suzuki Y,Urano T

更新日期：2011-01-01 00:00:00

abstract：:Our previous study showed that oridonin isolated from Rabdosia rubescens enhanced phagocytosis of apoptotic cells by macrophage-like U937 cells through tumor necrosis factor (TNF) alpha and interleukin (IL)-1beta release. In this study, we further investigated signaling events involved in oridonin-augmented phagocytos...

journal_title：Journal of pharmacological sciences

authors： Liu YQ,You S,Tashiro S,Onodera S,Ikejima T

更新日期：2005-08-01 00:00:00

abstract：:System L (SL), a basolateral amino acid transporter, transports large neutral amino acids (LNAAs) in a Na(+)-independent manner. Previously, we identified two isoforms of transporters: L-type amino acid transporter 1 (LAT1) and 2 (LAT2) and revealed their distinct substrate selectivity and transport properties. In thi...

journal_title：Journal of pharmacological sciences

authors： Morimoto E,Kanai Y,Kim DK,Chairoungdua A,Choi HW,Wempe MF,Anzai N,Endou H

更新日期：2008-12-01 00:00:00

abstract：:Lysophosphatidic acid (LPA) initiates demyelination following peripheral nerve injury, which causes neuropathic pain. Our previous in vivo and ex vivo studies using mice have demonstrated that LPA-induced demyelination of spinal dorsal roots is attributed by the LPA1-type receptor-mediated down-regulation of myelin-re...

journal_title：Journal of pharmacological sciences

authors： Tsukahara R,Ueda H

更新日期：2016-10-01 00:00:00

abstract：:The effect of T-2328 {2-fluoro-4'-methoxy-3'-[[[(2S,3S)-2-phenyl-3-piperidinyl]amino]methyl]-[1,1'-biphenyl]-4-carbonitrile dihydrochloride}, a novel tachykinin NK(1)-receptor antagonist, was examined on cisplatin-induced emesis in ferrets. Cisplatin induced acute emesis in 24 h and delayed emesis during 24 and 72 h, ...

journal_title：Journal of pharmacological sciences

authors： Watanabe Y,Okamoto M,Ishii T,Takatsuka S,Taniguchi H,Nagasaki M,Saito A

更新日期：2008-06-01 00:00:00

abstract：:This study examines the influence of receptor expression level on signaling pathways activated via endothelin type A receptor (ET(A)R) expressed in Chinese hamster ovary cells at 32,100 (ET(A)R-high-CHO) and 893 (ET(A)R-low-CHO) fmolmg protein(-1). Endothelin-1 (ET-1) elicited a sustained increase in intracellular Ca(...

journal_title：Journal of pharmacological sciences

authors： Horinouchi T,Asano H,Higa T,Nishimoto A,Nishiya T,Muramatsu I,Miwa S

更新日期：2009-12-01 00:00:00

abstract：:GbaSM-4 cells, vascular smooth muscle cells (VSMCs) derived from brain basilar arteries, were shown to migrate toward d-nicotine by augmenting the actin cytoskeleton in their cell bodies and lamellipodia, and expression of nicotinic acetylcholine receptor (alpha7-nAChR) was detected in GbaSM-4 cells. Their chemotaxis ...

journal_title：Journal of pharmacological sciences

authors： Li S,Zhao T,Xin H,Ye LH,Zhang X,Tanaka H,Nakamura A,Kohama K

更新日期：2004-03-01 00:00:00

abstract：:Overexpression of constitutively active (CA)-G alpha13 significantly increased the expression of interleukin (IL)-1beta and IL-6 mRNAs and proteins in rat cardiac fibroblasts. IL-1beta mRNA induction by CA-G alpha13 was suppressed by diphenyleneiodonium (DPI), an NADPH oxidase inhibitor, but not by BAPTA-AM, an intrac...

journal_title：Journal of pharmacological sciences

authors： Nagamatsu Y,Nishida M,Onohara N,Fukutomi M,Maruyama Y,Kobayashi H,Sato Y,Kurose H

更新日期：2006-06-01 00:00:00

abstract：:In conventional relative gene expression analysis (Northern blotting, RT-PCR, and in situ hybridization), housekeeping genes such as the glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and beta-actin genes, whose expression levels are considered stable, have been used as control genes for normalization of RNA quantit...

journal_title：Journal of pharmacological sciences

authors： Nishida Y,Sugahara-Kobayashi M,Takahashi Y,Nagata T,Ishikawa K,Asai S

更新日期：2006-05-01 00:00:00

abstract：:The purpose of this study is to identify transient receptor potential canonical (TRPC) channels responsible for receptor-operated Ca(2+) entry (ROCE) triggered by activation of endothelin type A receptor (ET(A)R) and to clarify the importance of calmodulin (CaM) / inositol 1,4,5-trisphosphate (IP(3)) receptor binding ...

journal_title：Journal of pharmacological sciences

authors： Horinouchi T,Terada K,Higa T,Aoyagi H,Nishiya T,Suzuki H,Miwa S

更新日期：2011-01-01 00:00:00

abstract：:Intravital multiphoton microscopy has opened a new era in the field of biological imaging. Focal excitation of fluorophores by simultaneous attack of multiple (normally "two") photons generates images with high spatial resolution, and use of near-infrared lasers for multiphoton excitation allows penetration of thicker...

journal_title：Journal of pharmacological sciences

authors： Kikuta J,Ishii M

更新日期：2012-01-01 00:00:00

abstract：:We prepared a colon cancer-bearing Yoshida sarcoma rat model to examine the dose-response relationship of antitumor activity of intracolonically or orally administered 5-fluorouracil (5-FU; 45, 30, 20, 13, and 8 mg/kg). At doses of > or =20 mg/kg and > or =30 mg/kg, the 5-FU intracolonic and oral administration groups...

journal_title：Journal of pharmacological sciences

authors： Goto T,Tomizawa N,Kobayashi E,Fujimura A

更新日期：2004-06-01 00:00:00

abstract：:The purpose of the current study was to explore the effects of N-methyl-D-aspartate (NMDA)-receptor antagonists (MK-801 and LY235959) administered intracerebroventricularly on the changes of both core temperature and hypothalamic levels of 2,3-dihydroxybenzoic acid (2,3-DHBA) induced by intracerebroventricular injecti...

journal_title：Journal of pharmacological sciences

authors： Kao CH,Kao TY,Huang WT,Lin MT

更新日期：2007-06-01 00:00:00

abstract：:Our previous study showed that organobismuth compounds induce apoptosis in human promyelocytic leukemia cells, although solid tumor cell lines were relatively resistant. Herein, we investigated the primary cellular target of these compounds in HeLa cells. One organobismuth compound, bi-chlorodibenzo[c,f][1,5]thiabismo...

journal_title：Journal of pharmacological sciences

authors： Iuchi K,Akagi K,Yagura T

更新日期：2009-04-01 00:00:00

abstract：:Chotosan (CTS), a traditional herbal formula called Kampo medicine, was shown to be effective in the treatment of vascular dementia in a clinical study, and exerted protective effects against transient cerebral ischemia-induced cognitive impairment in mice. In the present study, we investigated the neuroprotective eff...

journal_title：Journal of pharmacological sciences

authors： Sasaki-Hamada S,Suzuki A,Sanai E,Matsumoto K,Oka JI

更新日期：2017-11-01 00:00:00

abstract：:We investigated the effects of gabapentin and pregabalin on the itch-associated response in a mouse model of chronic dermatitis induced by the repeated application of 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one (oxazolone). Challenging the mice with oxazolone-induced chronic dermatitis with the oxazolone evoked severe...

journal_title：Journal of pharmacological sciences

authors： Tsukumo Y,Matsumoto Y,Miura H,Yano H,Manabe H

更新日期：2011-01-01 00:00:00

abstract：:The G protein-coupled receptors (GPCRs) form the largest and the most versatile superfamily that share a seven-transmembrane-spanning architecture. GPCR-signaling is involved in vision, taste, olfaction, sympathetic/parasympathetic nervous functions, metabolism, and immune regulation, indicating that GPCRs are extreme...

journal_title：Journal of pharmacological sciences

authors： Miyano K,Sudo Y,Yokoyama A,Hisaoka-Nakashima K,Morioka N,Takebayashi M,Nakata Y,Higami Y,Uezono Y

更新日期：2014-01-01 00:00:00