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Gabapentin and pregabalin inhibit the itch-associated response induced by the repeated application of oxazolone in mice.

Abstract：

:We investigated the effects of gabapentin and pregabalin on the itch-associated response in a mouse model of chronic dermatitis induced by the repeated application of 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one (oxazolone). Challenging the mice with oxazolone-induced chronic dermatitis with the oxazolone evoked severe and transient scratching behavior until 1 h after the application of oxazolone. Thereafter, a more mild and continuous scratching behavior was also observed for at least 8 h. Both severe and continuous scratching behaviors were suppressed by systemic injection of gabapentin and pregabalin. This effect of these compounds was correlated with its affinity for the α₂δ subunit of voltage-gated Ca²(+) channels. Intrathecal injection, but not peripheral treatment, with gabapentin inhibited the scratching behavior in this model. Gabapentin failed to suppress the scratching behavior induced by the intradermal injection of compound 48/80 in normal mice. The expression of the α₂δ-1 subunit in dorsal root ganglion (DRG) from mice following repeated application of oxazolone was significantly higher than that from normal mice. These results suggest that gabapentin and pregabalin show an anti-pruritic activity through α₂δ-subunit binding, and the up-regulation of the α₂δ-1 subunit in DRG may therefore play an important role in its anti-pruritic activity.

journal_name

J Pharmacol Sci

journal_title

Journal of pharmacological sciences

authors

Tsukumo Y,Matsumoto Y,Miura H,Yano H,Manabe H

doi

10.1254/jphs.10173fp

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

27-35

issue

1

eissn

1347-8613

issn

1347-8648

pii

JST.JSTAGE/jphs/10173FP

journal_volume

115

pub_type

杂志文章

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