Abstract:
:Prothymosin alpha (ProTα) suppresses stress-induced necrosis of cultured cortical neurons. As neuroprotection alone could not explain the long-lasting protective actions against cerebral ischemia by ProTα, we further examined whether ProTα, in addition to neuroprotective effects, has other anti-ischemic activities. When recombinant mouse ProTα (rmProTα) at 0.3 mg/kg was intravenously (i.v.) given 2 h after the start of tMCAO, all mice survived for more than 14 days. In evaluation of CD31- and tomato lectin-labeling as well as IgG and Evans blue leakage, rmProTα treatment (0.1 mg/kg) largely blocked ischemia-induced vascular damages. Therefore, rmProTα has novel beneficial effects against ischemia-induced brain damage through vascular mechanisms.
journal_name
J Pharmacol Scijournal_title
Journal of pharmacological sciencesauthors
Maeda S,Sasaki K,Halder SK,Fujita W,Ueda Hdoi
10.1016/j.jphs.2016.05.006subject
Has Abstractpub_date
2016-09-01 00:00:00pages
100-104issue
1eissn
1347-8613issn
1347-8648pii
S1347-8613(16)30058-5journal_volume
132pub_type
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