Myelin-related gene silencing mediated by LPA1 - Rho/ROCK signaling is correlated to acetylation of NFκB in S16 Schwann cells.

abstract：:Angiotensin II plays an important role in regulating blood pressure. Moreover, angiotensin II directly promotes organ damage by inducing expression of various genes, such as transforming growth factor (TGF)-β and matrix metalloproteinase (MMP)-9 precursors. Blockade of angiotensin II has been shown to not only lower b...

journal_title：Journal of pharmacological sciences

authors： Takai S,Jin D,Miyazaki M

更新日期：2012-01-01 00:00:00

abstract：:This study examined the effects of baicalin, a bioactive flavonoid isolated from Scutellariae Radix, on carbon tetrachloride (CCl(4))-induced liver injury. Mice were treated intraperitoneally with 0.5 ml/kg CCl(4) and different groups of animals received 25, 50, 100, and 200 mg/kg baicalin. At 24 h after the CCl(4) tr...

journal_title：Journal of pharmacological sciences

authors： Park SW,Lee CH,Kim YS,Kang SS,Jeon SJ,Son KH,Lee SM

更新日期：2008-01-01 00:00:00

abstract：:Despite of the huge socio-economic burden, stroke still represents an unmet therapeutic need. Researchers failed to reproduce preclinical efficacy in subsequent clinical development. To bridge this translation failure, the Stroke Therapy Academic Industry Round Table (STAIR) has suggested a rigorous, robust, and detai...

journal_title：Journal of pharmacological sciences

authors： Kaundal RK,Iyer S,Kumar A,Sharma SS

更新日期：2009-03-01 00:00:00

abstract：:We previously reported that nicotine (NIC)-induced analgesia was elicited in part by activation of the endogenous opioid system. Moreover, it is well known that NIC has physical-dependence liability, but its mechanism is unclear. Therefore, we examined whether physical dependence on NIC was mediated by activation of t...

journal_title：Journal of pharmacological sciences

authors： Ueno K,Kiguchi N,Kobayashi Y,Saika F,Wakida N,Yamamoto C,Maeda T,Ozaki M,Kishioka S

更新日期：2014-01-01 00:00:00

abstract：:Functional dyspepsia (FD) is thought to be mainly based on gastric motility dysfunction and chronic hypersensitivity, yet FD animal models has been reported a few. We studied to establish the mouse model of impaired gastric motility induced by a pungent ingredient of wasabi allyl isothiocyanate (AITC), which is reliab...

journal_title：Journal of pharmacological sciences

authors： Hashimoto K,Tashima K,Imai T,Matsumoto K,Horie S

更新日期：2021-01-01 00:00:00

abstract：:Patients with obstructive sleep apnea (OSA) have a high prevalence of atrial fibrillation (AF). Rivaroxaban, a coagulation factor Xa inhibitor, has recently been reported to show pleiotropic effects. This study investigated the influence of rivaroxaban on cardiac remodeling caused by intermittent hypoxia (IH). Male C5...

journal_title：Journal of pharmacological sciences

authors： Imano H,Kato R,Tanikawa S,Yoshimura F,Nomura A,Ijiri Y,Yamaguchi T,Izumi Y,Yoshiyama M,Hayashi T

更新日期：2018-07-01 00:00:00

abstract：:Hypoxia or hypoxia/reoxygenation impairs nitric oxide (NO)-mediated relaxation through the increase in superoxide generation in monkey coronary arteries. Soluble guanylate cyclase (sGC), the target enzyme of NO, has been shown to change from the NO-sensitive reduced form to the NO-insensitive oxidized/heme-free form u...

journal_title：Journal of pharmacological sciences

authors： Tawa M,Geddawy A,Shimosato T,Iwasaki H,Imamura T,Okamura T

更新日期：2014-01-01 00:00:00

abstract：:We investigated the roles of β- and α(2)-adrenoceptors within the central nucleus of the amygdala (CeA) in the negative affective and sensory components of visceral pain in rats. We observed a dose-dependent reduction of intraperitoneal acetic acid-induced conditioned place aversion by bilateral injections of timolol,...

journal_title：Journal of pharmacological sciences

authors： Deyama S,Takishita A,Tanimoto S,Ide S,Nakagawa T,Satoh M,Minami M

更新日期：2010-01-01 00:00:00

abstract：:We compared dilator actions of representative four Ca2+ channel blockers on the isolated lower esophagus sphincter (LES) and thoracic aorta from rats. Verapamil, diltiazem, nifedipine and cilnidipine suppressed KCl-induced contractions of LES and thoracic aorta in a concentration-dependent manner. The order of selecti...

journal_title：Journal of pharmacological sciences

authors： Takahara A,Nozaki S,Ishiguro A,Okamura K,Cao X,Aimoto M,Nagasawa Y

更新日期：2018-05-01 00:00:00

abstract：:Atherosclerotic lesions were observed in male and ovariectomized female Microminipig (MMP) fed a high fat and cholesterol diet with sodium cholate (HFCD/SC) for 3 months. HFCD/SC induced hypercholesterolemia accompanied by an increase in serum total cholesterol (T-Cho), low-density lipoprotein cholesterol (LDL-C), hig...

journal_title：Journal of pharmacological sciences

authors： Kawaguchi H,Miyoshi N,Miura N,Fujiki M,Horiuchi M,Izumi Y,Miyajima H,Nagata R,Misumi K,Takeuchi T,Tanimoto A,Yoshida H

更新日期：2011-01-01 00:00:00

abstract：:Arginine vasopressin (AVP) receptors have been classified into V1a, V1b, and V2 subtypes. Recent studies have demonstrated the involvement of AVP in anti-nociception and in morphine-induced anti-nociception. However, the roles of individual AVP-receptor subtypes have not been fully elucidated. Here, we have summarized...

journal_title：Journal of pharmacological sciences

authors： Honda K,Takano Y

更新日期：2009-01-01 00:00:00

abstract：:Cimetidine is known to suppress the growth of several tumors, including gastrointestinal cancer, in humans and animals. Nonetheless, whether other histamine H(2)-receptor antagonists exert such tumor suppressive effects remains unclear. The effect of roxatidine acetate hydrochloride (roxatidine), an H(2)-receptor anta...

journal_title：Journal of pharmacological sciences

authors： Tomita K,Izumi K,Okabe S

更新日期：2003-11-01 00:00:00

abstract：:We prepared a colon cancer-bearing Yoshida sarcoma rat model to examine the dose-response relationship of antitumor activity of intracolonically or orally administered 5-fluorouracil (5-FU; 45, 30, 20, 13, and 8 mg/kg). At doses of > or =20 mg/kg and > or =30 mg/kg, the 5-FU intracolonic and oral administration groups...

journal_title：Journal of pharmacological sciences

authors： Goto T,Tomizawa N,Kobayashi E,Fujimura A

更新日期：2004-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common neurodegenerative disorder of late life characterized by insidious, chronic, and progressive memory impairment in association with the accumulation of senile plaques, neurofibrillary tangles, and massive loss of neurons. Apoptosis is believed to be an important contributor t...

journal_title：Journal of pharmacological sciences

authors： Takuma K,Yan SS,Stern DM,Yamada K

更新日期：2005-03-01 00:00:00

abstract：:Antagonism of the dopamine D3 receptor has been hypothesized to be beneficial for schizophrenia cognitive deficits, negative symptoms and extrapyramidal symptoms. However, recent animal and human studies have shown that most antipsychotics do not occupy D3 receptors in vivo, despite their considerable binding affinity...

journal_title：Journal of pharmacological sciences

authors： Baba S,Enomoto T,Horisawa T,Hashimoto T,Ono M

更新日期：2015-03-01 00:00:00

abstract：:It has been widely accepted that macrophages are divided into M1 "pro-inflammatory" macrophages and M2 "anti-inflammatory" macrophages and an uncontrolled macrophage polarization plays an important role in the pathogenesis of different diseases. As the main substance of total glucosides of peony, paeoniflorin (PF), ha...

journal_title：Journal of pharmacological sciences

authors： Zhai T,Sun Y,Li H,Zhang J,Huo R,Li H,Shen B,Li N

更新日期：2016-03-01 00:00:00

abstract：:The role of nitric oxide (NO) in the changes in enterochromaffin cells and ileal 5-hydroxytryptamine (5-HT) content induced by a single i.p. administration of methotrexate was investigated in rats. Methotrexate significantly increased inducible NO synthase (iNOS) mRNA and protein expressions in the intestinal tissue a...

journal_title：Journal of pharmacological sciences

authors： Takano Y,Hirano M,Machida T,Obara Y,Hamaue N,Fujita K,Taniguchi M,Endo T,Shiga S,Machida M,Iizuka K,Hirafuji M

更新日期：2019-09-01 00:00:00

abstract：:Microminipigs are expected as a novel animal model for cardiovascular pharmacological experiments. Since inherent vulnerability of coronary circulation of microminipigs has not been characterized, we performed dipyridamole-stress test to both microminipigs and beagle dogs, and compared the results. Dipyridamole in dos...

journal_title：Journal of pharmacological sciences

authors： Ando K,Takahara A,Nakamura Y,Wada T,Chiba K,Goto A,Lubna NJ,Hagiwara-Nagasawa M,Izumi-Nakaseko H,Hoshiai K,Akie Y,Naito AT,Sugiyama A

更新日期：2018-02-01 00:00:00

abstract：:Synaptic transmission is conducted by neurotransmitters released from nerve terminals. Neurotransmitter release is regulated both positively and negatively by multiple mechanisms, and its regulation is believed to be one of the important mechanisms of synaptic plasticity underlying learning and memory. Various protein...

journal_title：Journal of pharmacological sciences

authors： Takahashi M,Itakura M,Kataoka M

更新日期：2003-09-01 00:00:00

abstract：:The mechanisms of action of acupuncture and moxibustion as reported by Japanese researchers are reviewed. The endogenous opioid-mediated mechanisms of electroacupuncture (EA) as used in China are well understood, but these are only one component of all mechanisms of acupuncture. These studies emphasize the similarity ...

journal_title：Journal of pharmacological sciences

authors： Kawakita K,Shinbara H,Imai K,Fukuda F,Yano T,Kuriyama K

更新日期：2006-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a group of small noncoding RNAs that regulate translational repression of multiple target mRNAs. The miRNAs in a whole cell regulate greater than 30% of all protein-coding genes. The vast majority of presently identified miRNAs are expressed in the brain in a spatially and temporally controlled ...

journal_title：Journal of pharmacological sciences

authors： Satoh J

更新日期：2010-01-01 00:00:00

abstract：:Differences of cell proliferation, cell cycle, and G(1)/S transition regulatory proteins of gingival fibroblasts derived from nifedipine-reactive patient (NIFr) and nifedipine-non-reactive patient (NIFn) in the presence of basic fibroblast growth factor (bFGF) were investigated to elucidate the mechanism of gingival o...

journal_title：Journal of pharmacological sciences

authors： Takeuchi R,Matsumoto H,Okada H,Hori M,Gunji A,Hakozaki K,Akimoto Y,Fujii A

更新日期：2007-02-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal lung disease characterized by inflammation, multifocal fibrotic lesions and excessive collagen deposition with limited therapies. As a major bioactive compound in garlic, S-allyl-l-cysteine (SAC) is a neuroprotective drug candidate to prevent cognitive de...

journal_title：Journal of pharmacological sciences

authors： Nie Y,Yu K,Li B,Hu Y,Zhang H,Xin R,Xiong Y,Zhao P,Chai G

更新日期：2019-04-01 00:00:00

abstract：:Luminal hydrogen sulfide (H(2)S), a gasotransmitter, causes colonic pain / referred hyperalgesia in mice, most probably via activation of T-type Ca(2+) channels. Here we analyzed the mechanisms for H(2)S-induced facilitation of colonic pain signals. Intracolonic administration of NaHS, an H(2)S donor, evoked visceral ...

journal_title：Journal of pharmacological sciences

authors： Tsubota-Matsunami M,Noguchi Y,Okawa Y,Sekiguchi F,Kawabata A

更新日期：2012-01-01 00:00:00

abstract：:The maladaptive response of aged microglia to surgery and consequent neuroinflammation plays a key pathogenic role in postoperative cognitive dysfunction (POCD). Here, we assessed the preventive effect of resveratrol (RESV) for POCD in aged rats. The emulsified form of RESV (e-RESV) was selected to improve its oral an...

journal_title：Journal of pharmacological sciences

authors： Locatelli FM,Kawano T,Iwata H,Aoyama B,Eguchi S,Nishigaki A,Yamanaka D,Tateiwa H,Shigematsu-Locatelli M,Yokoyama M

更新日期：2018-08-01 00:00:00

abstract：:Butyrate is widely accepted as a proliferation inhibitor in colon cancer but less thoroughly characterized in the colonic epithelium of objects with type 2 diabetes mellitus. The present study investigated the regulatory effect of butyrate on proliferation, the related molecule high-mobility group box 1 (HMGB1) and th...

journal_title：Journal of pharmacological sciences

authors： Wang SY,Li JY,Xu JH,Xia ZS,Cheng D,Zhong W,Lai Y,Yu T,Chen QK

更新日期：2019-04-01 00:00:00

abstract：:There is no direct evidence for the exact cilia-inhibitory effects of opioids, which are generally used to achieve general anesthesia in combination with other anesthetic drugs. These are the reasons, why we analysed direct concentration-dependent or systemic effects of anesthetics (propofol, sufentanil, and midazolam...

journal_title：Journal of pharmacological sciences

authors： Joskova M,Durdik P,Sutovska M,Grendar M,Koniar D,Hargas L,Banovcin P,Franova S

更新日期：2020-04-01 00:00:00

abstract：:Glutamate excitotoxicity mediated by N-methyl-d-aspartate (NMDA) receptors is an important cause of retinal ganglion cell death in glaucoma. To elucidate whether apelin protects against retinal neuronal cell death, we examined protective effects of exogenous and endogenous apelin on neuronal cell death induced by intr...

journal_title：Journal of pharmacological sciences

authors： Ishimaru Y,Sumino A,Kajioka D,Shibagaki F,Yamamuro A,Yoshioka Y,Maeda S

更新日期：2017-01-01 00:00:00

abstract：:The aim of this study was to investigate the contribution of gene polymorphisms, in combination with habitual caffeine consumption, to the effect of caffeine intake on hemodynamic and psychoactive parameters. A double-blind, prospective study was conducted with 201 healthy volunteers randomly allocated 2:1 to the caff...

journal_title：Journal of pharmacological sciences

authors： Yoshihara T,Zaitsu M,Shiraishi F,Arima H,Takahashi-Yanaga F,Arioka M,Kajioka S,Sasaguri T

更新日期：2019-03-01 00:00:00

abstract：:The supraspinal and spinal antinociceptive effects of several kappa-opioid receptor agonists were examined in diabetic and non-diabetic mice using the tail-flick assay. The antinociception induced by intrathecal (i.t.), but not intracerebroventricular (i.c.v.), CI-977, a highly selective kappa(1)-opioid receptor agoni...

journal_title：Journal of pharmacological sciences

authors： Ohsawa M,Kamei J

更新日期：2005-05-01 00:00:00