Abstract：
:The aim of this study was to investigate the contribution of gene polymorphisms, in combination with habitual caffeine consumption, to the effect of caffeine intake on hemodynamic and psychoactive parameters. A double-blind, prospective study was conducted with 201 healthy volunteers randomly allocated 2:1 to the caffeinated group (150 mL decaffeinated coffee with additional 200 mg caffeine) or decaffeinated group (150 mL decaffeinated coffee). We measured the changes in blood pressure (BP) and calculation speed upon coffee intake, stratifying with gene polymorphisms, e.g., those in adenosine A2A receptor (ADORA2A) and cytochrome P450 (CYP) 1A2, and daily caffeine consumption (≤90 mg/day and >90 mg/day). Overall, caffeine intake independently increased BP and calculation speed (p-values < 0.05), irrespective of the polymorphisms. In stratified analysis, a statistical significance within the caffeinated group was observed for the change in systolic BP in the stratum of CYP1A2 polymorphism with daily caffeine consumption ≤90 mg/day: change in systolic BP in the CYP1A2 rs762551 CC group (mean ± SD = 11.8 ± 5.9) was higher than that in the AA/CA group (4.1 ± 5.5). Gene polymorphisms may limitedly modify the effect of caffeine intake on hemodynamic parameters in combination with habitual caffeine consumption.
journal_name
J Pharmacol Scijournal_title
Journal of pharmacological sciencesauthors
Yoshihara T,Zaitsu M,Shiraishi F,Arima H,Takahashi-Yanaga F,Arioka M,Kajioka S,Sasaguri Tdoi
10.1016/j.jphs.2019.01.006subject
Has Abstractpub_date
2019-03-01 00:00:00pages
209-214issue
3eissn
1347-8613issn
1347-8648pii
S1347-8613(19)30011-8journal_volume
139pub_type
杂志文章,随机对照试验abstract：:To investigate whether miniature pigs are useful for evaluating the potential of drugs for drug-induced prolongation of the QT interval, we performed an in vivo QT assay using conscious and unrestricted miniature pigs. Compared with the vehicle average baseline values, haloperidol at 3 and 10 mg/kg, p.o. prolonged the...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1254/jphs.qt-c13
更新日期：2005-01-01 00:00:00
abstract：:Heat shock protein 90 (HSP90) antagonists are currently being evaluated as potential anticancer drugs. However, adverse effects related to these drugs, such as fatigue and pain, suggest that they affect neurons. Therefore, to understand the influence of HSP90 inhibitors on neurons, we investigated the effects of gelda...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1016/j.jphs.2019.07.011
更新日期：2019-07-01 00:00:00
abstract：:We characterized the effects of vanadate, an inhibitor of tyrosine phosphatase, on the tension, the level of myosin light chain (MLC) phosphorylation, and Rho A activation in intact ileal longitudinal smooth muscle of the guinea pig to study the role of tyrosine phosphorylation in contraction signaling. Vanadate exert...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1254/jphs.fp0030576
更新日期：2004-08-01 00:00:00
abstract：:To examine effects of volatile anesthetics (VAs) on steroidogenesis, cell suspensions of isolated bovine adrenocortical cells were incubated with several steroidogenic agents in the presence or absence of halothane and sevoflurane. The adrenocortical cells were dispersed by trypsin digestion of bovine adrenal cortex. ...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1254/jphs.93.210
更新日期：2003-10-01 00:00:00
abstract：:Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal lung disease characterized by inflammation, multifocal fibrotic lesions and excessive collagen deposition with limited therapies. As a major bioactive compound in garlic, S-allyl-l-cysteine (SAC) is a neuroprotective drug candidate to prevent cognitive de...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1016/j.jphs.2019.03.002
更新日期：2019-04-01 00:00:00
abstract：:Cardiovascular diseases are the most frequent and costly complication of diabetes. Many previous studies showed that ATP-sensitive potassium channels (K(ATP)) and inward rectifier potassium channels (Kir) play important regulatory roles in functions of cardiovascular tissues. It's still not very clear how these potass...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1254/jphs.93.478
更新日期：2003-12-01 00:00:00
abstract：:Nicotine inhibited interleukin (IL)-18 and -12 production in lipopolysaccharide (LPS)-stimulated monocytes, and the action of nicotine was antagonized by a non-selective and a selective alpha7 nicotinic acetylcholine receptor (alpha7-nAChR) antagonist, suggesting that the stimulation of alpha7-nAChR may be involved in...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1254/jphs.sc0060074
更新日期：2006-09-01 00:00:00
abstract：:Chotosan (CTS), a traditional herbal formula called Kampo medicine, was shown to be effective in the treatment of vascular dementia in a clinical study, and exerted protective effects against transient cerebral ischemia-induced cognitive impairment in mice. In the present study, we investigated the neuroprotective eff...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1016/j.jphs.2017.10.009
更新日期：2017-11-01 00:00:00
abstract：:The cell signaling cascades provoked by Wnt proteins (the Wnt signaling pathways), which are well conserved through evolution, play crucial roles to maintain homeostasis of a variety of tissues such as skin, blood, intestine, and brain, as well as to regulate proliferation, morphology, motility, and fate of cells duri...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章,评审
doi：10.1254/jphs.cr0070024
更新日期：2007-08-01 00:00:00
abstract：:Cancer remains a major health problem around the world. A Shiga toxin is a bacterial toxin often produced by Shigella dysenteriae and Escherichia coli. A subunit of the Shiga toxin (StxA) is a cytotoxic agent which could be used to induce death in cancer cells. StxA expressed from baculovirus was evaluated in a pTriEx...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1016/j.jphs.2018.09.003
更新日期：2018-09-01 00:00:00
abstract：:Glucocorticoids are stress hormones released from the adrenal cortex and their concentration is controlled by the hypothalamic-pituitary-adrenal axis. In this study, we investigated the effect of glucocorticoids on the number of astrocytes and glucocorticoid receptor (GR) expression in vitro and in vivo. Proliferation...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1254/jphs.12047fp
更新日期：2012-01-01 00:00:00
abstract：:The purpose of the current study was to explore the effects of N-methyl-D-aspartate (NMDA)-receptor antagonists (MK-801 and LY235959) administered intracerebroventricularly on the changes of both core temperature and hypothalamic levels of 2,3-dihydroxybenzoic acid (2,3-DHBA) induced by intracerebroventricular injecti...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1254/jphs.fp0070272
更新日期：2007-06-01 00:00:00
abstract：:Patients with obstructive sleep apnea (OSA) have a high prevalence of atrial fibrillation (AF). Rivaroxaban, a coagulation factor Xa inhibitor, has recently been reported to show pleiotropic effects. This study investigated the influence of rivaroxaban on cardiac remodeling caused by intermittent hypoxia (IH). Male C5...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1016/j.jphs.2018.07.002
更新日期：2018-07-01 00:00:00
abstract：:This study investigated the effects of thiol and heme oxidants on responsiveness to cGMP generators in isolated rat aorta and pulmonary artery using an organ chamber. The nitric oxide (NO) donor sodium nitroprusside (SNP)-induced relaxation was impaired by exposure to the thiol oxidant diamide in both the aorta and th...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1016/j.jphs.2019.04.002
更新日期：2019-05-01 00:00:00
abstract：:Neurosteroids are known as allosteric modulators of the ligand-gated ion channel superfamily. Voltage-gated sodium channels (Na(v)) play an important role in mediating excitotoxic damages. Here we report the effects of neurosteroids on the function of Na(v), using voltage-clamp techniques in Xenopus oocytes expressed ...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1254/jphs.12106sc
更新日期：2012-01-01 00:00:00
abstract：:Recent epidemiological studies have demonstrated that coffee drinking is associated with reduced mortality of cardiovascular disease. However, its precise mechanisms remain to be clarified. In this study, we examined whether single ingestion of caffeine contained in a cup of coffee improves microvascular function in h...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1016/j.jphs.2015.01.003
更新日期：2015-02-01 00:00:00
abstract：:Previous studies showed that diphenidol was effective on emetogens-induced pica, eating of non-nutritive substances, in rats, a model analogous to emesis in other species. We evaluated the actual antiemetic activity of diphenidol against four emetic stimuli in the dog and ferret, animals that possess an emetic reflex....
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1254/jphs.fpj04035x
更新日期：2004-11-01 00:00:00
abstract：:Polyriboinosinic-polyribocytidilic acid (polyI:C) is a synthetic analog that elicits viral-like immune responses in mammals. We have recently found that polyI:C treatment in neonatal mice induced abnormalities of emotional, cognitive, and sensorimotor gating and dysfunction of glutamatergic neurotransmission in adulth...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1254/jphs.12142fp
更新日期：2012-01-01 00:00:00
abstract：:Acid-sensing ion channels (ASICs) are proton-sensitive sodium channels that open in response to lowered extracellular pH and are expressed in the central and peripheral nervous systems. The ASIC3 subtype is found primarily in the periphery where the channel mediates pain signals caused by ischemia and inflammation. He...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1016/j.jphs.2017.02.007
更新日期：2017-03-01 00:00:00
abstract：:Nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the incidence of colorectal cancer. However, evidence is accumulating that NSAIDs have anti-cancer effects in addition to inhibiting cyclooxygenase (COX)-mediated prostanoid biosynthesis. We now show that indomethacin, a popular NSAID, significantly reduced the [3H]...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1254/jphs.08167sc
更新日期：2008-11-01 00:00:00
abstract：:Circulating levels of calcium ion (Ca(2+)) are maintained within a narrow physiological range mainly by the action of parathyroid hormone (PTH) secreted from parathyroid cells. Parathyroid cells can sense small fluctuations in plasma Ca(2+) levels by virtue of a cell surface Ca(2+) receptor (CaR) that belongs to the s...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章,评审
doi：10.1254/jphs.fmj04007x6
更新日期：2005-03-01 00:00:00
abstract：:A segment of guinea pig ileum was used to confirm the hypothesis that [6]-gingerol and lafutidine interact with capsaicin-sensitive neurons. Addition of 30 and 100 microM [6]-gingerol (a pungent constituent of ginger) induced contraction of the ileum immediately. Like capsaicin, [6]-gingerol-induced contraction was in...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1254/jphs.92.359
更新日期：2003-08-01 00:00:00
abstract：:Forsythiae Fructus is known to have diuretic, anti-bacterial, and anti-inflammatory activities. This study examined the hepatoprotective effects of pinoresinol, a lignan isolated from Forsythiae Fructus, against carbon tetrachloride (CCl(4))-induced liver injury. Mice were treated intraperitoneally with vehicle or pin...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1254/jphs.09234fp
更新日期：2010-01-01 00:00:00
abstract：:In the present study, the characteristics of the sleep features of amitriptyline, mexiletine, and N-(4-tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyradine-1(2H)-carbox-amide (BCTC) were studied. Electrodes were chronically implanted into the frontal cortex and the dorsal neck muscles of rats for electroen...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1254/jphs.08059fp
更新日期：2008-07-01 00:00:00
abstract：:Intravital multiphoton microscopy has opened a new era in the field of biological imaging. Focal excitation of fluorophores by simultaneous attack of multiple (normally "two") photons generates images with high spatial resolution, and use of near-infrared lasers for multiphoton excitation allows penetration of thicker...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章,评审
doi：10.1254/jphs.12r03cp
更新日期：2012-01-01 00:00:00
abstract：:Antagonism of the dopamine D3 receptor has been hypothesized to be beneficial for schizophrenia cognitive deficits, negative symptoms and extrapyramidal symptoms. However, recent animal and human studies have shown that most antipsychotics do not occupy D3 receptors in vivo, despite their considerable binding affinity...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1016/j.jphs.2015.01.007
更新日期：2015-03-01 00:00:00
abstract：:B cells are important in the development of autoimmune disorders through mechanisms involving dysregulated polyclonal B-cell activation, production of pathogenic antibodies, and targeting which reduces inflammation and tissue damage effectively but often leads to patients suffering from secondary infection. Paeoniflor...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1016/j.jphs.2015.02.011
更新日期：2015-05-01 00:00:00
abstract：:Polycyclic aromatic hydrocarbons (PAHs) and dioxins are ubiquitous environmental pollutants and activate the aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor. It has been reported that testosterone represses 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced transcription of the cytochrome P450 (CYP) ...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1254/jphs.08328fp
更新日期：2009-03-01 00:00:00
abstract：:Resveratrol is a stilbene compound found in grapes and other sources. In this study we examined the effects of trans-resveratrol (4.38 - 438 microM/implant) in the vasculogenesis of yolk-sac membranes and its capacity to improve chick embryo growth. High concentrations of the stilbene (43.8 - 438 microM) significantly...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1254/jphs.fp0071876
更新日期：2008-06-01 00:00:00
abstract：:Stiffness and cytokine in blood levels show 24-h rhythms in rheumatoid arthritis (RA) patients. We previously revealed that higher therapeutic effects were obtained in RA patients and RA model animals when the dosing time of methotrexate was chosen according to the 24-h rhythms to cytokine. In this study, we examined ...
journal_title：Journal of pharmacological sciences
pub_type： 杂志文章
doi：10.1254/jphs.11029fp
更新日期：2011-01-01 00:00:00
