当前位置： SCI文献检索 > JOURNAL OF PHARMACOLOGICAL SCIENCES期刊下所有文献 > Hepatoprotective effect of pinoresinol on carbon tetrachloride-induced hepatic damage in mice.

Hepatoprotective effect of pinoresinol on carbon tetrachloride-induced hepatic damage in mice.

Abstract：

:Forsythiae Fructus is known to have diuretic, anti-bacterial, and anti-inflammatory activities. This study examined the hepatoprotective effects of pinoresinol, a lignan isolated from Forsythiae Fructus, against carbon tetrachloride (CCl(4))-induced liver injury. Mice were treated intraperitoneally with vehicle or pinoresinol (25, 50, 100, and 200 mg/kg) 30 min before and 2 h after CCl4 (20 microl/kg) injection. In the vehicle-treated CCl(4 )group, serum aminotransferase activities were significantly increased 24 h after CCl4 injection, and these increases were attenuated by pinoresinol at all doses. Hepatic glutathione contents were significantly decreased and lipid peroxidation was increased after CCl4 treatment. These changes were attenuated by 50 and 100 mg/kg of pinoresinol. The levels of protein and mRNA expression of inflammatory mediators, including tumor necrosis factor-alpha, inducible nitric oxide synthase, and cyclooxygenase-2, were significantly increased after CCl4 injection; and these increases were attenuated by pinoresinol. Nuclear translocation of nuclear factor-kappaB (NF-kappaB) and phosphorylation of c-Jun, one of the components of activating protein 1 (AP-1), were inhibited by pinoresinol. Our results suggest that pinoresinol ameliorates CCl4)-induced acute liver injury, and this protection is likely due to anti-oxidative activity and down-regulation of inflammatory mediators through inhibition of NF-kappaB and AP-1.

journal_name

J Pharmacol Sci

journal_title

Journal of pharmacological sciences

authors

Kim HY,Kim JK,Choi JH,Jung JY,Oh WY,Kim DC,Lee HS,Kim YS,Kang SS,Lee SH,Lee SM

doi

10.1254/jphs.09234fp

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

105-12

issue

1

eissn

1347-8613

issn

1347-8648

pii

JST.JSTAGE/jphs/09234FP

journal_volume

112

pub_type

杂志文章

相关文献

JOURNAL OF PHARMACOLOGICAL SCIENCES文献大全
  • Selectivity of Ca2+ channel blockers for dilator actions on the isolated lower esophageal sphincter and aorta from rats.

    abstract：:We compared dilator actions of representative four Ca2+ channel blockers on the isolated lower esophagus sphincter (LES) and thoracic aorta from rats. Verapamil, diltiazem, nifedipine and cilnidipine suppressed KCl-induced contractions of LES and thoracic aorta in a concentration-dependent manner. The order of selecti...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2018.01.012

    authors： Takahara A,Nozaki S,Ishiguro A,Okamura K,Cao X,Aimoto M,Nagasawa Y

    更新日期：2018-05-01 00:00:00

  • Muscarinic M1 receptors stimulated by intracerebroventricular administration of McN-A-343 reduces the nerve injury-induced mechanical hypersensitivity via GABAB receptors rather than GABAA receptors in mice.

    abstract：:Cholinergic neurons play an important role in the higher functions of the brain, such as the memory, cognition, and nociception. However, the exact mechanism behind how the stimulation of all the muscarinic M1 receptors in the entire brain results in the alleviation of partial sciatic nerve ligation (PSNL)-induced mec...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2019.06.010

    authors： Migita K,Nishimura A,Eto F,Koga K,Matsumoto T,Terada K,Hara S,Honda K

    更新日期：2020-02-01 00:00:00

  • Lipopolysaccharide- and glutamate-induced hypothalamic hydroxyl radical elevation and fever can be suppressed by N-methyl-D-aspartate-receptor antagonists.

    abstract：:The purpose of the current study was to explore the effects of N-methyl-D-aspartate (NMDA)-receptor antagonists (MK-801 and LY235959) administered intracerebroventricularly on the changes of both core temperature and hypothalamic levels of 2,3-dihydroxybenzoic acid (2,3-DHBA) induced by intracerebroventricular injecti...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.fp0070272

    authors： Kao CH,Kao TY,Huang WT,Lin MT

    更新日期：2007-06-01 00:00:00

  • Effect of selective serotonin reuptake inhibitors via 5-HT1A receptors on L-DOPA-induced rotational behavior in a hemiparkinsonian rat model.

    abstract：:L-Dihydroxyphenylalanine (L-DOPA) is considered the gold standard for the treatment of Parkinson's disease (PD). However, long-term administration of L-DOPA can induce abnormal side effects. On the other hand, selective serotonin reuptake inhibitors (SSRIs) including fluoxetine have gained tremendous popularity in the...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.12003fp

    authors： Inden M,Abe M,Minamino H,Takata K,Yoshimoto K,Tooyama I,Kitamura Y

    更新日期：2012-01-01 00:00:00

  • Simvastatin, an HMG-CoA reductase inhibitor, reduced the expression of matrix metalloproteinase-9 (Gelatinase B) in osteoblastic cells and HT1080 fibrosarcoma cells.

    abstract：:MMP-9 or Gelatinase B, a member of the matrix metalloproteinase family (MMPs), plays important roles in physiological events such as tissue remodeling and in pathological processes that lead to destructive bone diseases, including osteoarthritis and periodontitis. In addition to its effect on the increase of total bon...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.94.403

    authors： Thunyakitpisal PD,Chaisuparat R

    更新日期：2004-04-01 00:00:00

  • Antidepressant-like effect of venlafaxine is abolished in μ-opioid receptor-knockout mice.

    abstract：:Although the opioid system is known to modulate depression-like behaviors, its role in the effects of antidepressants is not yet clear. We investigated the role of μ-opioid receptors (MOPs) in the effects of venlafaxine, a serotonin and norepinephrine reuptake inhibitor, in the forced swim test using MOP-knockout (KO)...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.10136sc

    authors： Ide S,Fujiwara S,Fujiwara M,Sora I,Ikeda K,Minami M,Uhl GR,Ishihara K

    更新日期：2010-01-01 00:00:00

  • Haloperidol affects coupling between QT and RR intervals in guinea pig isolated heart.

    abstract：:Prolonged QT interval is an independent risk factor for development of ventricular arrhythmias. Haloperidol is one of the drugs inducing QT prolongation. Previous studies showed that haloperidol affects not only QT duration but also heart rate (RR interval). The present work focused on relationship between QT and RR a...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2018.11.004

    authors： Vesely P,Stracina T,Hlavacova M,Halamek J,Kolarova J,Olejnickova V,Mrkvicova V,Paulova H,Novakova M

    更新日期：2019-01-01 00:00:00

  • Effect of oleoylethanolamide on diet-induced nonalcoholic fatty liver in rats.

    abstract：:Oleoylethanolamine (OEA), an endogenous high-affinity agonist of peroxisome proliferator-activated receptor alpha (PPAR-α), has revealed the pharmacological properties in the treatment of obesity, atherosclerosis and other diseases through the modulation of lipid metabolism. To assess whether OEA can also regulate non...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2014.12.001

    authors： Li L,Li L,Chen L,Lin X,Xu Y,Ren J,Fu J,Qiu Y

    更新日期：2015-03-01 00:00:00

  • Different chronotherapeutic effects of valsartan and olmesartan in non-dipper hypertensive patients during valsartan treatment at morning.

    abstract：:This study was undertaken to evaluate the differences in chronotherapeutic effects of angiotensin-II receptor blockers, valsartan and olmesartan in hypertensive patients with non-dipper blood pressure (BP) pattern during valsartan at morning. Ninety four patients were enrolled, and 40 patients were judged to be non-di...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.jphs.2014.09.004

    authors： Ushijima K,Nakashima H,Shiga T,Harada K,Ishikawa S,Ioka T,Ando H,Fujimura A

    更新日期：2015-01-01 00:00:00

  • Cellular mechanisms underlying the inhibitory effect of flufenamic acid on chloride secretion in human intestinal epithelial cells.

    abstract：:Intestinal Cl- secretion is involved in the pathogenesis of secretory diarrheas including cholera. We recently demonstrated that flufenamic acid (FFA) suppressed Vibrio cholerae El Tor variant-induced intestinal fluid secretion via mechanisms involving AMPK activation and NF-κB-suppression. The present study aimed to ...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2017.05.009

    authors： Pongkorpsakol P,Yimnual C,Chatsudthipong V,Rukachaisirikul V,Muanprasat C

    更新日期：2017-06-01 00:00:00

  • Mithramycin, an agent for developing new therapeutic drugs for neurodegenerative diseases.

    abstract：:Mithramycin A (MTM) has been shown to inhibit cancer growth by blocking the binding of Sp-family transcription factors to gene regulatory elements and is used for the treatment of leukemia and testicular cancer in the United States. In contrast, MTM has also been shown to exert neuroprotective effects in normal cells....

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章,评审

    doi：10.1254/jphs.13r02cp

    authors： Osada N,Kosuge Y,Ishige K,Ito Y

    更新日期：2013-01-01 00:00:00

  • Adoptive transfer of type 1 regulatory T cells suppressed the development of airway hyperresponsiveness in ovalbumin-induced airway inflammation model mice.

    abstract：:Type 1 regulatory T (Tr1) cells are CD4+ T cells that produce a large amount of IL-10, an anti-inflammatory cytokine. However, it has not been fully elucidated whether Tr1 cells suppress allergic asthma. In this study, the effects of adoptive transfer of in vitro-induced Tr1 cells on allergic asthma were evaluated. Sp...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2019.10.004

    authors： Matsuda M,Doi K,Tsutsumi T,Inaba M,Hamaguchi J,Terada T,Kawata R,Kitatani K,Nabe T

    更新日期：2019-12-01 00:00:00

  • Effects of mannitol on ischemia-induced degeneration in rat hippocampus.

    abstract：:Although mannitol has been used as an osmotherapeutic drug on brain injury, the clinical efficiency of the drug are still controversial. In the present study, we examined the effects of mannitol on the edema in a hippocampal slice due to brief ischemia. To evaluate the effects, we employed an image analysis system tha...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.fp0030565

    authors： Nakajima R,Nakamura T,Miyakawa H,Kudo Y

    更新日期：2004-07-01 00:00:00

  • Analysis of the effects of anesthetics and ethanol on mu-opioid receptor.

    abstract：:G protein-coupled receptors, in particular, Ca(2+)-mobilizing G(q)-coupled receptors have been reported to be targets for anesthetics. Opioids are commonly used analgesics in clinical practice, but the effects of anesthetics on the opioid mu-receptors (muOR) have not been systematically examined. We report here an ele...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.10003fp

    authors： Minami K,Sudo Y,Shiraishi S,Seo M,Uezono Y

    更新日期：2010-01-01 00:00:00

  • Basic and translational research on proteinase-activated receptors: antagonism of the proteinase-activated receptor 1 for thrombin, a novel approach to antiplatelet therapy for atherothrombotic disease.

    abstract：:Atherothrombotic disease is a leading public health problem. Although current antiplatelet agents, such as aspirin and adenosine diphosphate (ADP)-receptor antagonists, reduce the morbidity and mortality associated with atherothrombotic disease, the residual risk for ischemic events remains substantial. The high resid...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.08r06fm

    authors： Chintala M,Shimizu K,Ogawa M,Yamaguchi H,Doi M,Jensen P

    更新日期：2008-12-01 00:00:00

  • Involvement of histamine released from mast cells in acute radiation dermatitis in mice.

    abstract：:A possible involvement of histamine in acute radiation dermatitis in mice was investigated. The dose of 40 Gy of gamma irradiation induced erythema and edema in C57BL/6 mice treated with vehicle. However, in C57BL/6 mice treated with chlorpheniramine and WBB6F1-W/Wv mice, erythema and edema were not observed. In all o...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.sc0070127

    authors： Moriyasu S,Yamamoto K,Kureyama N,Okamura K,Ikeda T,Yamatodani A

    更新日期：2007-06-01 00:00:00

  • Colonic hydrogen sulfide-induced visceral pain and referred hyperalgesia involve activation of both Ca(v)3.2 and TRPA1 channels in mice.

    abstract：:Luminal hydrogen sulfide (H(2)S), a gasotransmitter, causes colonic pain / referred hyperalgesia in mice, most probably via activation of T-type Ca(2+) channels. Here we analyzed the mechanisms for H(2)S-induced facilitation of colonic pain signals. Intracolonic administration of NaHS, an H(2)S donor, evoked visceral ...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.12086sc

    authors： Tsubota-Matsunami M,Noguchi Y,Okawa Y,Sekiguchi F,Kawabata A

    更新日期：2012-01-01 00:00:00

  • Decrease in the kainate-induced wet dog shake behavior in genetically epilepsy-prone rats: possible involvement of an impaired synaptic transmission to the 5-HT(2A) receptor.

    abstract：:Genetically epilepsy-prone rats (GEPR-9s) were derived from Sprague-Dawley rats (SD). The number of kainate-induced wet dog shake behavior (WDS) responses was found to decrease significantly in GEPR-9s compared to SD. WDS responses were potentiated by 5-hydroxytryptophan or 2,5-dimethoxy-4-iodoamphetamine and antagoni...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.09015sc

    authors： Shin EJ,Jeong JH,Chung YH,Kim TW,Shin CY,Kim WK,Ko KH,Kim HC

    更新日期：2009-07-01 00:00:00

  • A simple in vivo atrial fibrillation model of rat induced by transesophageal atrial burst pacing.

    abstract：:A simple in vivo closed-chest atrial fibrillation (Af) model of rats was developed. Af was reproducibly induced by transesophageal atrial burst pacing for 30 s in each of the pentobarbital-anesthetized rats, whereas the cardiohemodynamic condition as well as the inducibility and duration of Af episode was stable over ...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.scj05002x

    authors： Sugiyama A,Takahara A,Honsho S,Nakamura Y,Hashimoto K

    更新日期：2005-07-01 00:00:00

  • In vivo inhibition of CYP3A-mediated midazolam metabolism by anchusan in rats.

    abstract：:Cytochrome P450 (CYP)-mediated drug interactions caused by Kampo medicine have not been investigated sufficiently. The current study was conducted to reveal the effect of anchusan, a commonly used Kampo formula for gastrointestinal disease, on CYP3A-mediated drug metabolism in rats. The pharmacokinetics of midazolam (...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.10277fp

    authors： Saito Y,Nishimura Y,Kurata N,Iwase M,Aoki K,Yasuhara H

    更新日期：2011-01-01 00:00:00

  • Dentin hypersensitivity-like tooth pain seen in patients receiving steroid therapy: An exploratory study.

    abstract：:To ascertain whether steroid therapy evokes dentin hypersensitivity (DH)-like tooth pain, we performed a study based on compelling evidence from patients receiving steroid therapy. An exploratory study was conducted using a questionnaire for 220 patients prescribed steroids who attended the Department of Hematology an...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2016.10.004

    authors： Shoji N,Endo Y,Iikubo M,Ishii T,Harigae H,Aida J,Sakamoto M,Sasano T

    更新日期：2016-11-01 00:00:00

  • Effects of subchronic treatment with selegiline on L-DOPA-induced increase in extracellular dopamine level in rat striatum.

    abstract：:Selegiline is used an adjunct to L-DOPA therapy. We investigated extracellular striatal dopamine (DA) level in awake rats treated with L-DOPA and/or selegiline using a microdialysis method. Rats given 10 mg/kg, i.p. per day selegiline for 7 days were administered with a single dose of 100 mg/kg, i.p. L-DOPA 0 (3 h), 1...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.fp0051085

    authors： Adachi K,Miwa H,Kusumoto H,Shimazu S,Kondo T

    更新日期：2006-08-01 00:00:00

  • Regulation of ryanodine receptor-mediated Ca(2+) release in vas deferens smooth muscle cells.

    abstract：:Ca(2+) release from intracellular store sites via the ryanodine receptor (RyR) and hormonal regulation by flutamide, an androgen-receptor (AR) antagonist, on it were examined in vas deferens (VD) smooth muscle cells (SMCs). VD and VDSMCs were obtained from two groups of male rats that were treated p.o. with 100 mg/kg ...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.09037fp

    authors： Ohno A,Ohya S,Yamamura H,Imaizumi Y

    更新日期：2009-05-01 00:00:00

  • P-glycoprotein-evading anti-tumor activity of a novel tubulin and HSP90 dual inhibitor in a non-small-cell lung cancer model.

    abstract：:P-glycoprotein (P-gp)-induced drug resistance is a major road block for successful cancer chemotherapy. Through phenotypic screening, the compound 2-(2-chlorophenylimino)-5-(4-dimethylaminobenzylidene) thiazolidin-4-one (CDBT) was discovered to have potent anti-tumor activity in P-gp over-expressing drug-resistant non...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.14050fp

    authors： Zhang Q,Zhai S,Li L,Li X,Jiang C,Zhang C,Yan B

    更新日期：2014-01-01 00:00:00

  • Soluble guanylate cyclase redox state under hypoxia or hypoxia/reoxygenation in isolated monkey coronary arteries.

    abstract：:Hypoxia or hypoxia/reoxygenation impairs nitric oxide (NO)-mediated relaxation through the increase in superoxide generation in monkey coronary arteries. Soluble guanylate cyclase (sGC), the target enzyme of NO, has been shown to change from the NO-sensitive reduced form to the NO-insensitive oxidized/heme-free form u...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.14046fp

    authors： Tawa M,Geddawy A,Shimosato T,Iwasaki H,Imamura T,Okamura T

    更新日期：2014-01-01 00:00:00

  • Blonanserin suppresses impulsive action in rats.

    abstract：:High impulsivity will increase the risk of criminal behavior, drug abuse, and suicide. We chose two drugs by following a strategy recently we proposed for identifying potential anti-impulsivity drugs, and examined the effects on impulsive action in rats by using a 3-choice serial reaction time task. We showed that the...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2019.09.013

    authors： Nishitani N,Sasamori H,Ohmura Y,Yoshida T,Yoshioka M

    更新日期：2019-11-01 00:00:00

  • Novel cognitive enhancer ST101 enhances acetylcholine release in mouse dorsal hippocampus through T-type voltage-gated calcium channel stimulation.

    abstract：:We recently developed a novel cognitive enhancer, ST101 (spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one), that activates T-type voltage-gated calcium channels (VGCCs). Here, we address whether T-type VGCC activation with ST101 mediates its cognitive effects in vivo and the relevance of T-type VGCC activation to ace...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.12233fp

    authors： Yamamoto Y,Shioda N,Han F,Moriguchi S,Fukunaga K

    更新日期：2013-01-01 00:00:00

  • A perspective on metabolic surgery from a gastroenterologist.

    abstract：:Type 2 diabetes (T2D) and obesity are important public health problems. The global prevalence of diabetes mellitus is 8.8%. Interventional diabetology and obesitology have been recently advocated as treatment options for T2D and obesity. The roles of metabolic surgery such as Roux-en-Y gastric bypass, sleeve gastrecto...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.jphs.2017.01.001

    authors： Syu YF,Inui A,Chen CY

    更新日期：2017-02-01 00:00:00

  • KR-31466, a benzopyranylindol analog, attenuates hypoxic injury through mitochondrial K(ATP) channel and protein kinase C activation in heart-derived H9c2 cells.

    abstract：:In the present study, we investigated whether a novel benzopyranylindol analogue, KR-31466 (KR466) (1-[(2S,3R,4S)-3,4-dihydro-2-dimethoxymethyl-3-hydroxy-2-methyl-6-nitro-2H-1-benzopyran-4-yl]-1H-indole-2-carboxylic acid ethyl ester) can attenuate hypoxic injury in heart-derived H9c2 cells and, if so, whether the prot...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.92.13

    authors： Jung YS,Jung YS,Kim MY,Kim MH,Lee S,Yi KY,Yoo SE,Lee SH,Baik EJ,Moon CH,Cho JP

    更新日期：2003-05-01 00:00:00

  • Characterization and comparison of sodium-glucose cotransporter 2 inhibitors in pharmacokinetics, pharmacodynamics, and pharmacologic effects.

    abstract：:The sodium-glucose cotransporter (SGLT) 2 offer a novel approach to treating type 2 diabetes by reducing hyperglycaemia via increased urinary glucose excretion. In the present study, the pharmacokinetic, pharmacodynamic, and pharmacologic properties of all six SGLT2 inhibitors commercially available in Japan were inve...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2016.02.003

    authors： Tahara A,Takasu T,Yokono M,Imamura M,Kurosaki E

    更新日期：2016-03-01 00:00:00