Effects of geldanamycin on neurite outgrowth-related proteins and kinases in nerve growth factor-differentiated pheochromocytoma 12 cells.

abstract：:2-Aminophenoxazine-3-one (Phx-3) induced cellular apoptosis in mouse melanoma B16 cells as detected by DNA laddering and upregulated Fas expression in the cells in vitro. Next, the anti-metastatic effects of Phx-3 were investigated in C56BL/6 mice. When B16 melanoma cells were injected into the tail veins of mice, sig...

journal_title：Journal of pharmacological sciences

authors： Hongo T,Miyano-Kurosaki N,Kurosaki K,Hata A,Harigae S,Tomoda A

更新日期：2010-01-01 00:00:00

abstract：:By using immunofluorostaining and confocal laser microscopy, acetylcholine-induced translocation of RhoA was visualized in freshly isolated bronchial smooth muscle cells of the rat. The cellular distribution of RhoA at rest was observed uniformly in the cytosolic space with no staining in the nucleus, whereas acetylch...

journal_title：Journal of pharmacological sciences

authors： Chiba Y,Uchida T,Sakai H,Oku T,Itoh S,Tsuji T,Misawa M

更新日期：2004-08-01 00:00:00

abstract：:Metabolic syndrome (MetS) induces serious complications; therefore, we developed a noninvasive MetS model using an extremely small minipig, the Microminipig. For 8 weeks, Microminipigs were administrated a high-fat and high-cholesterol diet (HFCD) for atherosclerosis and N(G)-nitro-l-arginine methyl ester (l-NAME) for...

journal_title：Journal of pharmacological sciences

authors： Yamaguchi T,Yamazaki T,Kawaguchi H,Tawa M,Nakamura Y,Shiota M,Osada-Oka M,Tanimoto A,Okamura T,Miura K,Iwao H,Yoshiyama M,Izumi Y

更新日期：2014-01-01 00:00:00

abstract：:Ischemia/reperfusion (I/R)-induced oxidative stress is a serious clinical problem in the reperfusion therapy for ischemic diseases. Tumstatin is an endogenous bioactive peptide cleaved from type IV collagen α3 chain. We previously reported that T3 peptide, an active subfragment of tumstatin, exerts cytoprotective effe...

journal_title：Journal of pharmacological sciences

authors： Yasuda J,Okada M,Yamawaki H

更新日期：2019-03-01 00:00:00

abstract：:Aspirin (acetylsalicylic acid) is a well-known nonsteroidal anti-inflammatory drug that can potentiate some acute allergies and causes adverse immunological reactions collectively referred to as aspirin intolerance, a disorder that induces urticaria, asthma, and anaphylaxis in response to oral administration of the dr...

journal_title：Journal of pharmacological sciences

authors： Suzuki Y,Ra C

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVE:Treatment with the chemotherapeutic agent, doxorubicin (DOX), is limited by side effects. We have previously demonstrated that fasudil, a Rho/ROCK inhibitor, has antioxidant, anti-inflammatory and anti-apoptotic effects in contrast-induced acute kidney injury model. The present study to investigated the possi...

journal_title：Journal of pharmacological sciences

authors： Xiang C,Yan Y,Zhang D

更新日期：2021-01-01 00:00:00

abstract：:The sodium-glucose cotransporter (SGLT) 2 offer a novel approach to treating type 2 diabetes by reducing hyperglycaemia via increased urinary glucose excretion. In the present study, the pharmacokinetic, pharmacodynamic, and pharmacologic properties of all six SGLT2 inhibitors commercially available in Japan were inve...

journal_title：Journal of pharmacological sciences

authors： Tahara A,Takasu T,Yokono M,Imamura M,Kurosaki E

更新日期：2016-03-01 00:00:00

abstract：:Functional dyspepsia (FD) is thought to be mainly based on gastric motility dysfunction and chronic hypersensitivity, yet FD animal models has been reported a few. We studied to establish the mouse model of impaired gastric motility induced by a pungent ingredient of wasabi allyl isothiocyanate (AITC), which is reliab...

journal_title：Journal of pharmacological sciences

authors： Hashimoto K,Tashima K,Imai T,Matsumoto K,Horie S

更新日期：2021-01-01 00:00:00

abstract：:Ca(2+) is a central player in the excitation-contraction coupling of cardiac myocytes, the process that enables the heart to contract and relax. Mishandling of Ca(2+) is a central cause of both contractile dysfunction and arrhythmias in pathophysiological conditions such as heart failure (HF). Upon electrical excitati...

journal_title：Journal of pharmacological sciences

authors： Bers DM,Despa S

更新日期：2006-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a group of small noncoding RNAs that regulate translational repression of multiple target mRNAs. The miRNAs in a whole cell regulate greater than 30% of all protein-coding genes. The vast majority of presently identified miRNAs are expressed in the brain in a spatially and temporally controlled ...

journal_title：Journal of pharmacological sciences

authors： Satoh J

更新日期：2010-01-01 00:00:00

abstract：:Arginine vasopressin (AVP) receptors have been classified into V1a, V1b, and V2 subtypes. Recent studies have demonstrated the involvement of AVP in anti-nociception and in morphine-induced anti-nociception. However, the roles of individual AVP-receptor subtypes have not been fully elucidated. Here, we have summarized...

journal_title：Journal of pharmacological sciences

authors： Honda K,Takano Y

更新日期：2009-01-01 00:00:00

abstract：:The purpose of this study is to identify transient receptor potential canonical (TRPC) channels responsible for receptor-operated Ca(2+) entry (ROCE) triggered by activation of endothelin type A receptor (ET(A)R) and to clarify the importance of calmodulin (CaM) / inositol 1,4,5-trisphosphate (IP(3)) receptor binding ...

journal_title：Journal of pharmacological sciences

authors： Horinouchi T,Terada K,Higa T,Aoyagi H,Nishiya T,Suzuki H,Miwa S

更新日期：2011-01-01 00:00:00

abstract：:Epigenetics is a mechanism that regulates gene expression not depending on the underlying DNA sequence, but on the chemical modifications of DNA and histone proteins. Defects in the factors involved in epigenetic regulation cause congenital neurodevelopmental diseases, and thus, epigenetic regulation is essential for ...

journal_title：Journal of pharmacological sciences

authors： Kubota T,Miyake K,Hirasawa T,Nagai K,Koide T

更新日期：2010-01-01 00:00:00

abstract：:Mithramycin A (MTM) has been shown to inhibit cancer growth by blocking the binding of Sp-family transcription factors to gene regulatory elements and is used for the treatment of leukemia and testicular cancer in the United States. In contrast, MTM has also been shown to exert neuroprotective effects in normal cells....

journal_title：Journal of pharmacological sciences

authors： Osada N,Kosuge Y,Ishige K,Ito Y

更新日期：2013-01-01 00:00:00

abstract：:Sargassum hemiphyllum (SH) has long been used in Korean folk medicine for the therapeutic treatment of various allergic diseases. The effects of SH in previous experimental models, however, have been inconclusive. We studied the effects of methanol extract of SH on mast cells. Our experiments showed that SH significan...

journal_title：Journal of pharmacological sciences

authors： Na HJ,Moon PD,Ko SG,Lee HJ,Jung HA,Hong SH,Seo Y,Oh JM,Lee BH,Choi BW,Kim HM

更新日期：2005-02-01 00:00:00

abstract：:Chotosan (CTS), a traditional herbal formula called Kampo medicine, was shown to be effective in the treatment of vascular dementia in a clinical study, and exerted protective effects against transient cerebral ischemia-induced cognitive impairment in mice. In the present study, we investigated the neuroprotective eff...

journal_title：Journal of pharmacological sciences

authors： Sasaki-Hamada S,Suzuki A,Sanai E,Matsumoto K,Oka JI

更新日期：2017-11-01 00:00:00

abstract：:Multimodal analgesic approaches to manage acute and chronic pain are commonly used in humans. Here, we attempted to characterize a synergistic interaction between fentanyl, tramadol, and paracetamol on the inhibition of nociception in a model of visceral pain in mice. The three-drug combined treatment displayed a pote...

journal_title：Journal of pharmacological sciences

authors： Fernández-Dueñas V,Poveda R,Sánchez S,Ciruela F

更新日期：2012-01-01 00:00:00

abstract：:Endothelin type A receptor (ETAR) is internalized upon agonist stimulation; however, the mechanism thereof remains controversial. In this study, we characterized the endothelin-1 (ET-1)-induced internalization of ETAR expressed in Chinese hamster ovary cells. ET-1 elicited ETAR internalization and increase in intracel...

journal_title：Journal of pharmacological sciences

authors： Horinouchi T,Karki S,Terada K,Mazaki Y,Miwa S

更新日期：2019-05-01 00:00:00

abstract：:Microminipigs are expected as a novel animal model for cardiovascular pharmacological experiments. Since inherent vulnerability of coronary circulation of microminipigs has not been characterized, we performed dipyridamole-stress test to both microminipigs and beagle dogs, and compared the results. Dipyridamole in dos...

journal_title：Journal of pharmacological sciences

authors： Ando K,Takahara A,Nakamura Y,Wada T,Chiba K,Goto A,Lubna NJ,Hagiwara-Nagasawa M,Izumi-Nakaseko H,Hoshiai K,Akie Y,Naito AT,Sugiyama A

更新日期：2018-02-01 00:00:00

abstract：:Cytochrome P450 (CYP) catalyzes the oxidation of many endogenous and xenobiotic compounds. The expression of CYP isozymes are modulated by endogenous hormones and xenobiotics. We found that, although CYP2C11 and CYP3A2 are adult male-specific isozymes, they are also expressed in prepubertal female Sprague Dawley (SD) ...

journal_title：Journal of pharmacological sciences

authors： Ishii T,Nishimura K,Nishimura M

更新日期：2006-07-01 00:00:00

abstract：:Leptin is an adipose tissue-derived secretory hormone that suppresses appetite by inhibition of neuropepeptide Y (NPY) gene expression in arcuate nucleus (ARC) in the hypothalamus. To investigate the transcriptional regulation of NPY gene by leptin, we carried out a luciferase assay using NPY gene promotor plasmid (NP...

journal_title：Journal of pharmacological sciences

authors： Higuchi H,Hasegawa A,Yamaguchi T

更新日期：2005-07-01 00:00:00

abstract：:Baicalin from Scutellaria baicalensis is a major flavonoid constituent found in the traditional Chinese medicinal herb Baikal skull cap. It has been widely used for the treatment of various diseases such as pneumonia, diarrhea, and hepatitis. Recent studies have demonstrated that baicalin possesses a wide range of pha...

journal_title：Journal of pharmacological sciences

authors： Kim ME,Kim HK,Park HY,Kim DH,Chung HY,Lee JS

更新日期：2013-01-01 00:00:00

abstract：:Serotonin/noradrenaline reuptake inhibitors (SNRIs) are widely used for the treatment for major depressive disorder, but these drugs induce several side effects including increased aggression and impulsivity, which are risk factors for substance abuse, criminal involvement, and suicide. To address this issue, milnacip...

journal_title：Journal of pharmacological sciences

authors： Tsutsui-Kimura I,Ohmura Y,Yoshida T,Yoshioka M

更新日期：2017-07-01 00:00:00

abstract：:Mosapride citrate (mosapride), a prokinetic agent with 5-HT(4)-receptor agonistic activity, is known to enhance gastric emptying and alleviate symptoms in patients with functional dyspepsia (FD). As hyperalgesia and delayed gastric emptying play an important role in the pathogenesis of FD, we used in this study balloo...

journal_title：Journal of pharmacological sciences

authors： Seto Y,Yoshida N,Kaneko H

更新日期：2011-01-01 00:00:00

abstract：:B cells are important in the development of autoimmune disorders through mechanisms involving dysregulated polyclonal B-cell activation, production of pathogenic antibodies, and targeting which reduces inflammation and tissue damage effectively but often leads to patients suffering from secondary infection. Paeoniflor...

journal_title：Journal of pharmacological sciences

authors： Zhang J,Li H,Huo R,Zhai T,Li H,Sun Y,Shen B,Li N

更新日期：2015-05-01 00:00:00

abstract：:The prevalence rate of cardiovascular disease is higher for males than females, and estradiol (E2) induces AMP-activated protein kinase (AMPK) activation, which is known to regulate proliferation of VSMC. We identified the estrogenic properties of nordihydroguaiaretic acid (NDGA, a lignan phytoestrogen) that inhibit V...

journal_title：Journal of pharmacological sciences

authors： Kim SA,Lee KY,Kim JR,Choi HC

更新日期：2016-09-01 00:00:00

abstract：:Clinically, hemorrhoidal bleeding and prolapse disappeared immediately after injection of the sclerosing agent OC-108 into submucosa of hemorrhoids. The aim of this study was to elucidate the mechanism of action responsible for the immediate hemostatic effect of OC-108 using anesthetized rats. Subcutaneous injection o...

journal_title：Journal of pharmacological sciences

authors： Ono T,Nakagawa H,Fukunari A,Hashimoto T,Komatsu H

更新日期：2006-11-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPARgamma) is a ligand-dependent transcriptional factor implicated in regulating adipogenesis, glucose homeostasis, and in mediating the action of the insulin sensitizing anti-diabetic thiazolidinedione (TZD) compounds. [3-(2,4-Dichlorobenzyl)-2-methyl-N-(pentylsulfony...

journal_title：Journal of pharmacological sciences

authors： Fujimura T,Sakuma H,Konishi S,Oe T,Hosogai N,Kimura C,Aramori I,Mutoh S

更新日期：2005-12-01 00:00:00

abstract：:P-glycoprotein (P-gp)-induced drug resistance is a major road block for successful cancer chemotherapy. Through phenotypic screening, the compound 2-(2-chlorophenylimino)-5-(4-dimethylaminobenzylidene) thiazolidin-4-one (CDBT) was discovered to have potent anti-tumor activity in P-gp over-expressing drug-resistant non...

journal_title：Journal of pharmacological sciences

authors： Zhang Q,Zhai S,Li L,Li X,Jiang C,Zhang C,Yan B

更新日期：2014-01-01 00:00:00

abstract：:The role of extracellular calcium in the interaction between intracellular cAMP and nitric oxide (NO)/cGMP on the contractility of rat diaphragm pretreated with cumulative concentrations of aminophylline (0.36 - 3.60 mM) was investigated. In a Ca2+-free medium, NG-nitro-L-arginine methyl ester (L-NAME) (1 and 3 mM) de...

journal_title：Journal of pharmacological sciences

authors： Stojanovic R,Todorović Z,Nesić Z,Vućković S,Cerovac-Cosić N,Prostran M

更新日期：2004-12-01 00:00:00