当前位置： SCI文献检索 > JOURNAL OF PHARMACOLOGICAL SCIENCES期刊下所有文献 > 2-aminophenoxazine-3-one prevents pulmonary metastasis of mouse B16 melanoma cells in mice.

2-aminophenoxazine-3-one prevents pulmonary metastasis of mouse B16 melanoma cells in mice.

Abstract：

:2-Aminophenoxazine-3-one (Phx-3) induced cellular apoptosis in mouse melanoma B16 cells as detected by DNA laddering and upregulated Fas expression in the cells in vitro. Next, the anti-metastatic effects of Phx-3 were investigated in C56BL/6 mice. When B16 melanoma cells were injected into the tail veins of mice, significant metastasis of the cells was indicated in the lungs, 14 days after treatment. In contrast, when 0.5 mg/kg Phx-3 was administered to mice through the tail veins, once simultaneously with or every three days after the administration of B16 melanoma cells, the number of metastasized pulmonary cells was extremely reduced. Moderate reduction of the number of metastasized pulmonary cells was indicated in the mice with a single dose of Phx-3 on day 3 after injection of the cells. However, when Phx-3 was administered in a single dose, 6 or 9 days after the injection of the cells, the number of metastasized pulmonary cells remained the same. The present results indicate that the metastasis of mouse B16 melanoma cells to the lung was significantly inhibited in mice administered Phx-3, which activated the intrinsic and extrinsic apoptotic pathways. The present study suggests that Phx-3 might be a potential anti-metastatic agent as well as an anticancer agent.

journal_name

J Pharmacol Sci

journal_title

Journal of pharmacological sciences

authors

Hongo T,Miyano-Kurosaki N,Kurosaki K,Hata A,Harigae S,Tomoda A

doi

10.1254/jphs.10023fp

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

63-8

issue

1

eissn

1347-8613

issn

1347-8648

pii

JST.JSTAGE/jphs/10023FP

journal_volume

114

pub_type

杂志文章

相关文献

JOURNAL OF PHARMACOLOGICAL SCIENCES文献大全
  • Progress in allergy signal research on mast cells: systemic approach to mast cell biology in allergic diseases.

    abstract：:At the end of the last century, microarray technology that examines the total genes and transcripts present in a cell became available as a laboratory tool. Mast cells are known to play a pivotal role in initiating allergic inflammation by releasing various mediators and cytokines. According to the recent microarray-b...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章,评审

    doi：10.1254/jphs.fm0070192

    authors： Saito H

    更新日期：2008-03-01 00:00:00

  • FK614, a novel peroxisome proliferator-activated receptor gamma modulator, induces differential transactivation through a unique ligand-specific interaction with transcriptional coactivators.

    abstract：:Peroxisome proliferator-activated receptor gamma (PPARgamma) is a ligand-dependent transcriptional factor implicated in regulating adipogenesis, glucose homeostasis, and in mediating the action of the insulin sensitizing anti-diabetic thiazolidinedione (TZD) compounds. [3-(2,4-Dichlorobenzyl)-2-methyl-N-(pentylsulfony...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.fp0050578

    authors： Fujimura T,Sakuma H,Konishi S,Oe T,Hosogai N,Kimura C,Aramori I,Mutoh S

    更新日期：2005-12-01 00:00:00

  • Glucocorticoids decrease astrocyte numbers by reducing glucocorticoid receptor expression in vitro and in vivo.

    abstract：:Glucocorticoids are stress hormones released from the adrenal cortex and their concentration is controlled by the hypothalamic-pituitary-adrenal axis. In this study, we investigated the effect of glucocorticoids on the number of astrocytes and glucocorticoid receptor (GR) expression in vitro and in vivo. Proliferation...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.12047fp

    authors： Unemura K,Kume T,Kondo M,Maeda Y,Izumi Y,Akaike A

    更新日期：2012-01-01 00:00:00

  • Alleviation of the doxorubicin-induced nephrotoxicity by fasudil in vivo and in vitro.

    abstract：OBJECTIVE:Treatment with the chemotherapeutic agent, doxorubicin (DOX), is limited by side effects. We have previously demonstrated that fasudil, a Rho/ROCK inhibitor, has antioxidant, anti-inflammatory and anti-apoptotic effects in contrast-induced acute kidney injury model. The present study to investigated the possi...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2020.10.002

    authors： Xiang C,Yan Y,Zhang D

    更新日期：2021-01-01 00:00:00

  • The role of muscarinic receptor subtypes on carbachol-induced contraction of normal human detrusor and overactive detrusor associated with benign prostatic hyperplasia.

    abstract：:The aim of this study was to compare the effect of antimuscarinic antagonists on carbachol-induced contraction of normal human bladder and detrusor overactivity associated with benign prostatic hyperplasia (DO/BPH). Samples of human bladder muscle were obtained from patients undergoing total cystectomy for bladder can...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2015.05.005

    authors： Yamanishi T,Kaga K,Fuse M,Shibata C,Kamai T,Uchiyama T

    更新日期：2015-06-01 00:00:00

  • Stress and vascular responses: oxidative stress and endothelial dysfunction in the insulin-resistant state.

    abstract：:Although insulin-resistant states have been associated with endothelial dysfunction due to increased vascular oxidative stress, the underlying mechanisms are pooly understood. Recent experimental evidence suggests that tetrahydrobiopterin (BH(4)), the natural and essential cofactor of NO synthases (NOS), plays a cruci...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章,评审

    doi：10.1254/jphs.91.187

    authors： Shinozaki K,Kashiwagi A,Masada M,Okamura T

    更新日期：2003-03-01 00:00:00

  • Pyrrolidine dithiocarbamate reduces vascular prostanoid-induced responses in aged type 2 diabetic rat model.

    abstract：:It has been shown that enhancement of vasoconstrictor prostanoids plays an important role in the development of cardiovascular diseases. The aim of the present study was to examine the effects of pyrrolidine dithiocarbamate (PDTC), a low-molecular-weight thiol antioxidant and a potent inhibitor of nuclear factor-kappa...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.09116fp

    authors： Matsumoto T,Ishida K,Kobayashi T,Kamata K

    更新日期：2009-07-01 00:00:00

  • Muscarinic M1 receptors stimulated by intracerebroventricular administration of McN-A-343 reduces the nerve injury-induced mechanical hypersensitivity via GABAB receptors rather than GABAA receptors in mice.

    abstract：:Cholinergic neurons play an important role in the higher functions of the brain, such as the memory, cognition, and nociception. However, the exact mechanism behind how the stimulation of all the muscarinic M1 receptors in the entire brain results in the alleviation of partial sciatic nerve ligation (PSNL)-induced mec...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2019.06.010

    authors： Migita K,Nishimura A,Eto F,Koga K,Matsumoto T,Terada K,Hara S,Honda K

    更新日期：2020-02-01 00:00:00

  • The effects of 2,3-dimercapto-1-propanesulfonic acid (DMPS) and meso-2,3-dimercaptosuccinic acid (DMSA) on the nephrotoxicity in the mouse during repeated cisplatin (CDDP) treatments.

    abstract：:Previously, we reported that specific lower dose of sodium 2,3-dimercapto-1-propanesulfonic acid (DMPS) which is an antidote to heavy metal intoxication, inversely enhanced cisplatin (CDDP)-induced antitumor activity to S-180 cell-bearing mouse. This activity was only weak with meso-2,3-dimercaptosuccinic acid (DMSA),...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2017.05.006

    authors： Yajima Y,Kawaguchi M,Yoshikawa M,Okubo M,Tsukagoshi E,Sato K,Katakura A

    更新日期：2017-06-01 00:00:00

  • Dosing time-dependency of the arthritis-inhibiting effect of tacrolimus in mice.

    abstract：:Stiffness and cytokine in blood levels show 24-h rhythms in rheumatoid arthritis (RA) patients. We previously revealed that higher therapeutic effects were obtained in RA patients and RA model animals when the dosing time of methotrexate was chosen according to the 24-h rhythms to cytokine. In this study, we examined ...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.11029fp

    authors： Obayashi K,Tomonari M,Yoshimatsu H,Fukuyama R,Ieiri I,Higuchi S,To H

    更新日期：2011-01-01 00:00:00

  • Calf Spleen Extractive Injection (CSEI), a small peptides enriched extraction, induces human hepatocellular carcinoma cell apoptosis via ROS/MAPKs dependent mitochondrial pathway.

    abstract：:Calf Spleen Extractive Injection (CSEI), a small peptides enriched extraction, performs immunomodulatory activity on cancer patients suffering from radiotherapy or chemotherapy. The present study aims to investigate the anti-hepatocellular carcinoma effects of CSEI in cells and tumor-xenografted mouse models. In HepG2...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2016.08.006

    authors： Jia D,Lu W,Zhang X,Cai G,Teng L,Wang X,Zhang M,Zeng Y,Liang C,Wang D

    更新日期：2016-10-01 00:00:00

  • Baicalin from Scutellaria baicalensis impairs Th1 polarization through inhibition of dendritic cell maturation.

    abstract：:Baicalin from Scutellaria baicalensis is a major flavonoid constituent found in the traditional Chinese medicinal herb Baikal skull cap. It has been widely used for the treatment of various diseases such as pneumonia, diarrhea, and hepatitis. Recent studies have demonstrated that baicalin possesses a wide range of pha...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.12200fp

    authors： Kim ME,Kim HK,Park HY,Kim DH,Chung HY,Lee JS

    更新日期：2013-01-01 00:00:00

  • Oral administration of fisetin promotes the induction of hippocampal long-term potentiation in vivo.

    abstract：:To explore memory enhancing effect of the flavonoid fisetin, we investigated the effect of oral administration of flavonoids on the induction of long-term potentiation (LTP) at hippocampal CA1 synapses of anesthetized rats. Among four flavonoids (fisetin, quercetin, luteolin and myricetin) tested, only fisetin signifi...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2017.12.008

    authors： He WB,Abe K,Akaishi T

    更新日期：2018-01-01 00:00:00

  • Hepatoprotective effect of pinoresinol on carbon tetrachloride-induced hepatic damage in mice.

    abstract：:Forsythiae Fructus is known to have diuretic, anti-bacterial, and anti-inflammatory activities. This study examined the hepatoprotective effects of pinoresinol, a lignan isolated from Forsythiae Fructus, against carbon tetrachloride (CCl(4))-induced liver injury. Mice were treated intraperitoneally with vehicle or pin...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.09234fp

    authors： Kim HY,Kim JK,Choi JH,Jung JY,Oh WY,Kim DC,Lee HS,Kim YS,Kang SS,Lee SH,Lee SM

    更新日期：2010-01-01 00:00:00

  • Intrathecally administered D-cycloserine produces nociceptive behavior through the activation of N-methyl-D-aspartate receptor ion-channel complex acting on the glycine recognition site.

    abstract：:Intrathecal (i.t.) administration of D-cycloserine (100 and 300 fmol), a partial agonist of the glycine recognition site on the N-methyl-D-aspartate (NMDA) receptor ion-channel complex, produced a behavioral response mainly consisting of biting and/or licking of the hindpaw and the tail along with slight hindlimb scra...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.fp0070203

    authors： Tan-No K,Esashi A,Nakagawasai O,Niijima F,Furuta S,Sato T,Satoh S,Yasuhara H,Tadano T

    更新日期：2007-05-01 00:00:00

  • New aspects of neurotransmitter release and exocytosis: regulation of neurotransmitter release by phosphorylation.

    abstract：:Synaptic transmission is conducted by neurotransmitters released from nerve terminals. Neurotransmitter release is regulated both positively and negatively by multiple mechanisms, and its regulation is believed to be one of the important mechanisms of synaptic plasticity underlying learning and memory. Various protein...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章,评审

    doi：10.1254/jphs.93.41

    authors： Takahashi M,Itakura M,Kataoka M

    更新日期：2003-09-01 00:00:00

  • Haloperidol affects coupling between QT and RR intervals in guinea pig isolated heart.

    abstract：:Prolonged QT interval is an independent risk factor for development of ventricular arrhythmias. Haloperidol is one of the drugs inducing QT prolongation. Previous studies showed that haloperidol affects not only QT duration but also heart rate (RR interval). The present work focused on relationship between QT and RR a...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2018.11.004

    authors： Vesely P,Stracina T,Hlavacova M,Halamek J,Kolarova J,Olejnickova V,Mrkvicova V,Paulova H,Novakova M

    更新日期：2019-01-01 00:00:00

  • p38 mitogen-activated protein kinase contributes to angiotensin II-stimulated migration of rat aortic smooth muscle cells.

    abstract：:In this study, we clarified the intracellular mechanism of angiotensin II (Ang II) in promoting migration in rat aortic smooth muscle cells (RASMCs). RASMC migration was measured with the Boyden chamber assay, and the result was confirmed with an aortic sprout assay. The activities of kinases were investigated by west...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.fp0070770

    authors： Lee HM,Lee CK,Lee SH,Roh HY,Bae YM,Lee KY,Lim J,Park PJ,Park TK,Lee YL,Won KJ,Kim B

    更新日期：2007-09-01 00:00:00

  • Probucol ameliorates hepatic stellate cell activation and autophagy is associated with farnesoid X receptor.

    abstract：:Probucol has antioxidant effects and inhibits inflammation. Farnesoid X receptor (FXR) is a nuclear receptor that regulates autophagy, which is regarded as the key cause of the activation of hepatic stellate cell (HSC). In this study, the effects of probucol on HSC activation and autophagy in vitro and vivo and the ro...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2018.12.005

    authors： Yang R,Hu Z,Zhang P,Wu S,Song Z,Shen X,Wei Z

    更新日期：2019-02-01 00:00:00

  • Cellular mechanisms underlying the inhibitory effect of flufenamic acid on chloride secretion in human intestinal epithelial cells.

    abstract：:Intestinal Cl- secretion is involved in the pathogenesis of secretory diarrheas including cholera. We recently demonstrated that flufenamic acid (FFA) suppressed Vibrio cholerae El Tor variant-induced intestinal fluid secretion via mechanisms involving AMPK activation and NF-κB-suppression. The present study aimed to ...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2017.05.009

    authors： Pongkorpsakol P,Yimnual C,Chatsudthipong V,Rukachaisirikul V,Muanprasat C

    更新日期：2017-06-01 00:00:00

  • Genome-wide association study identifies polymorphisms associated with the analgesic effect of fentanyl in the preoperative cold pressor-induced pain test.

    abstract：:Opioid analgesics are widely used for the treatment of moderate to severe pain. The analgesic effects of opioids are well known to vary among individuals. The present study focused on the genetic factors that are associated with interindividual differences in pain and opioid sensitivity. We conducted a multistage geno...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2018.02.002

    authors： Takahashi K,Nishizawa D,Kasai S,Koukita Y,Fukuda KI,Ichinohe T,Ikeda K

    更新日期：2018-03-01 00:00:00

  • Dopamine inhibits lipopolysaccharide-induced nitric oxide production through the formation of dopamine quinone in murine microglia BV-2 cells.

    abstract：:Dopamine (DA) has been suggested to modulate functions of glial cells including microglial cells. To reveal the regulatory role of DA in microglial function, in the present study, we investigated the effect of DA on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in murine microglial cell line BV-2. Pret...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2015.11.002

    authors： Yoshioka Y,Sugino Y,Tozawa A,Yamamuro A,Kasai A,Ishimaru Y,Maeda S

    更新日期：2016-02-01 00:00:00

  • Protective effect of baicalin against carbon tetrachloride-induced acute hepatic injury in mice.

    abstract：:This study examined the effects of baicalin, a bioactive flavonoid isolated from Scutellariae Radix, on carbon tetrachloride (CCl(4))-induced liver injury. Mice were treated intraperitoneally with 0.5 ml/kg CCl(4) and different groups of animals received 25, 50, 100, and 200 mg/kg baicalin. At 24 h after the CCl(4) tr...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.fp0071392

    authors： Park SW,Lee CH,Kim YS,Kang SS,Jeon SJ,Son KH,Lee SM

    更新日期：2008-01-01 00:00:00

  • Myelin-related gene silencing mediated by LPA1 - Rho/ROCK signaling is correlated to acetylation of NFκB in S16 Schwann cells.

    abstract：:Lysophosphatidic acid (LPA) initiates demyelination following peripheral nerve injury, which causes neuropathic pain. Our previous in vivo and ex vivo studies using mice have demonstrated that LPA-induced demyelination of spinal dorsal roots is attributed by the LPA1-type receptor-mediated down-regulation of myelin-re...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2016.07.010

    authors： Tsukahara R,Ueda H

    更新日期：2016-10-01 00:00:00

  • Effects of rosuvastatin and pitavastatin on ischemia-induced myocardial stunning in dogs.

    abstract：:Incomplete recovery of myocardial contraction after reperfusion following brief ischemia is called the "stunning phenomenon" in an animal experiment. A hydrophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor (statin) does not affect this phenomenon, but lipophilic statins further reduce the con...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1254/jphs.08017fp

    authors： Satoh K,Takaguri A,Itagaki M,Kano S,Ichihara K

    更新日期：2008-04-01 00:00:00

  • Endothelial progenitor cells: therapeutic target for cardiovascular diseases.

    abstract：:Circulating endothelial progenitor cells (EPCs) derived from bone marrow were isolated for the first time in 1997 and characterized. Recent evidence has indicated that EPCs contribute to re-endothelialization of injured vessels as well as neovascularization of ischemic lesions and that a decrease in the number of EPCs...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章,评审

    doi：10.1254/jphs.08r01cp

    authors： Umemura T,Higashi Y

    更新日期：2008-09-01 00:00:00

  • Neuroprotective DAMPs member prothymosin alpha has additional beneficial actions against cerebral ischemia-induced vascular damages.

    abstract：:Prothymosin alpha (ProTα) suppresses stress-induced necrosis of cultured cortical neurons. As neuroprotection alone could not explain the long-lasting protective actions against cerebral ischemia by ProTα, we further examined whether ProTα, in addition to neuroprotective effects, has other anti-ischemic activities. Wh...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2016.05.006

    authors： Maeda S,Sasaki K,Halder SK,Fujita W,Ueda H

    更新日期：2016-09-01 00:00:00

  • How do acupuncture and moxibustion act? - Focusing on the progress in Japanese acupuncture research -.

    abstract：:The mechanisms of action of acupuncture and moxibustion as reported by Japanese researchers are reviewed. The endogenous opioid-mediated mechanisms of electroacupuncture (EA) as used in China are well understood, but these are only one component of all mechanisms of acupuncture. These studies emphasize the similarity ...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章,评审

    doi：10.1254/jphs.crj06004x

    authors： Kawakita K,Shinbara H,Imai K,Fukuda F,Yano T,Kuriyama K

    更新日期：2006-01-01 00:00:00

  • Interaction between anti-Alzheimer and antipsychotic drugs in modulating extrapyramidal motor disorders in mice.

    abstract：:Antipsychotics are often used in conjunction with anti-Alzheimer drugs to treat the behavioral and psychological symptoms of dementia (BPSD). Here, we examined the effects of cholinesterase inhibitors (ChEIs), donepezil and galantamine, on antipsychotic-induced extrapyramidal side effects (EPS) in mice. The effects of...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2015.03.004

    authors： Shimizu S,Mizuguchi Y,Sobue A,Fujiwara M,Morimoto T,Ohno Y

    更新日期：2015-04-01 00:00:00

  • S-allyl-l-cysteine attenuates bleomycin-induced pulmonary fibrosis and inflammation via AKT/NF-κB signaling pathway in mice.

    abstract：:Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal lung disease characterized by inflammation, multifocal fibrotic lesions and excessive collagen deposition with limited therapies. As a major bioactive compound in garlic, S-allyl-l-cysteine (SAC) is a neuroprotective drug candidate to prevent cognitive de...

    journal_title：Journal of pharmacological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jphs.2019.03.002

    authors： Nie Y,Yu K,Li B,Hu Y,Zhang H,Xin R,Xiong Y,Zhao P,Chai G

    更新日期：2019-04-01 00:00:00