Abstract:
:Sargassum hemiphyllum (SH) has long been used in Korean folk medicine for the therapeutic treatment of various allergic diseases. The effects of SH in previous experimental models, however, have been inconclusive. We studied the effects of methanol extract of SH on mast cells. Our experiments showed that SH significantly inhibited compound 48/80-induced histamine and beta-hexosaminidase release from rat peritoneal mast cells. SH inhibited interleukin (IL)-8 and tumor necrosis factor (TNF)-alpha release induced by phorbol 12-myristate 13-acetate and A23187 from HMC-1, and it also showed an inhibitory effect on the anti-dinitrophenyl IgE antibody-induced passive cutaneous anaphylaxis reaction. In addition, SH inhibited the increase of TNF-alpha-induced NF-kappaB protein levels, transcription factor of TNF-alpha from 293T cells. A period of 48 h exposure to SH had little effect on HMC-1 cell viability. Our results suggest that SH has an inhibitory effect on the atopic allergic reaction and thus this may be useful in the treatment of allergic inflammatory diseases, such as atopic dermatitis.
journal_name
J Pharmacol Scijournal_title
Journal of pharmacological sciencesauthors
Na HJ,Moon PD,Ko SG,Lee HJ,Jung HA,Hong SH,Seo Y,Oh JM,Lee BH,Choi BW,Kim HMdoi
10.1254/jphs.fp0040326subject
Has Abstractpub_date
2005-02-01 00:00:00pages
219-26issue
2eissn
1347-8613issn
1347-8648pii
JST.JSTAGE/jphs/FP0040326journal_volume
97pub_type
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