当前位置： SCI文献检索 > JOURNAL OF PHARMACOLOGICAL SCIENCES期刊下所有文献 > Involvement of neuronal nitric oxide synthase in N-methyl-N-nitrosourea-induced retinal degeneration in mice.

Involvement of neuronal nitric oxide synthase in N-methyl-N-nitrosourea-induced retinal degeneration in mice.

Abstract：

:N-methyl-N-nitrosourea (MNU) is widely used to study the mechanism of retinal degenerative diseases (RDs) because of its selectivity of photoreceptor cell death. Many reports suggest that excessive nitric oxide (NO) plays a crucial role in neuronal cell death. We hypothesized that nitric oxide synthase (NOS)/NO are involved in photoreceptor cell death by MNU. We found that the levels of NO increased after MNU treatment. Furthermore, we demonstrated that neuronal NOS specific inhibitor attenuated photoreceptor cell death by MNU in mice. We believe that our findings might be a new target for the treatment of RDs.

journal_name

J Pharmacol Sci

journal_title

Journal of pharmacological sciences

authors

Koriyama Y,Hisano S,Ogai K,Sugitani K,Furukawa A,Kato S

doi

10.1016/j.jphs.2015.02.008

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

394-6

issue

3

eissn

1347-8613

issn

1347-8648

pii

S1347-8613(15)00040-7

journal_volume

127

pub_type

杂志文章

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