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A simple in vivo atrial fibrillation model of rat induced by transesophageal atrial burst pacing.

Abstract：

:A simple in vivo closed-chest atrial fibrillation (Af) model of rats was developed. Af was reproducibly induced by transesophageal atrial burst pacing for 30 s in each of the pentobarbital-anesthetized rats, whereas the cardiohemodynamic condition as well as the inducibility and duration of Af episode was stable over time. Moreover, the anti-Af effect of the class Ic drug pilsicainide was confirmed in this model, which was essentially the same as those reported previously in other Af animal models and clinical practice. Thus, this new model may become an alternative to current techniques.

journal_name

J Pharmacol Sci

journal_title

Journal of pharmacological sciences

authors

Sugiyama A,Takahara A,Honsho S,Nakamura Y,Hashimoto K

doi

10.1254/jphs.scj05002x

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

315-8

issue

3

eissn

1347-8613

issn

1347-8648

pii

JST.JSTAGE/jphs/SCJ05002X

journal_volume

98

pub_type

杂志文章

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