Abstract:
:A possible involvement of histamine in acute radiation dermatitis in mice was investigated. The dose of 40 Gy of gamma irradiation induced erythema and edema in C57BL/6 mice treated with vehicle. However, in C57BL/6 mice treated with chlorpheniramine and WBB6F1-W/Wv mice, erythema and edema were not observed. In all of these mice, epilation and dry desquamation were induced, but bepotastine significantly reduced the extent of these areas. These results suggest that gamma irradiation-induced erythema and edema were caused by histamine released from mast cells via histamine H1 receptor, and epilation was induced by other inflammatory mediators.
journal_name
J Pharmacol Scijournal_title
Journal of pharmacological sciencesauthors
Moriyasu S,Yamamoto K,Kureyama N,Okamura K,Ikeda T,Yamatodani Adoi
10.1254/jphs.sc0070127subject
Has Abstractpub_date
2007-06-01 00:00:00pages
187-90issue
2eissn
1347-8613issn
1347-8648pii
JST.JSTAGE/jphs/SC0070127journal_volume
104pub_type
杂志文章abstract::Evidence has shown that hyperlipidemia is associated with retinoid dyshomeostasis. In liver, retinol is mainly oxidized to retinal by retinol dehydrogenases (RDHs) and alcohol dehydrogenases (ADHs), further converted to retinoic acid by retinal dehydrogenases (RALDHs). The aim of this study was to investigate whether ...
journal_title:Journal of pharmacological sciences
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journal_title:Journal of pharmacological sciences
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journal_title:Journal of pharmacological sciences
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journal_title:Journal of pharmacological sciences
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journal_title:Journal of pharmacological sciences
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journal_title:Journal of pharmacological sciences
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journal_title:Journal of pharmacological sciences
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journal_title:Journal of pharmacological sciences
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journal_title:Journal of pharmacological sciences
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journal_title:Journal of pharmacological sciences
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