Abstract:
:Five isoforms of Na+/Ca2+ exchanger have been identified: NCX1, NCX2, NCX3, NCX-SQ1, and CALX. In all of the exchangers, the Na+/Ca2+ exchange current, which was recorded in inside-out membrane patches, was regulated by cytoplasmic Ca2+. However, the mode of regulation is different among the exchangers. NCX1, NCX2, and NCX-SQ1 are positively regulated by cytoplasmic Ca2+, but CALX is negatively regulated. NCX3 apparently has both positive and negative regulation mechanisms. In this review, I briefly summarize the Ca2+ -dependent regulation mechanisms of the exchangers.
journal_name
J Pharmacol Scijournal_title
Journal of pharmacological sciencesauthors
Matsuoka Sdoi
10.1254/jphs.fmj04002x2subject
Has Abstractpub_date
2004-09-01 00:00:00pages
12-4issue
1eissn
1347-8613issn
1347-8648pii
JST.JSTAGE/jphs/FMJ04002X2journal_volume
96pub_type
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