Abstract:
:We investigated the effects of sleep-inducing agents with different mechanisms of action on the loss of the righting reflex induced by isoflurane or a mixture of medetomidine, midazolam, and butorphanol (MMB), followed by atipamezole reversal. Chlorpromazine and brotizolam delayed recovery from both types of anesthesia, whereas the melatonin receptor agonist ramelteon had no effect. The orexin receptor antagonist suvorexant delayed recovery from anesthesia only in the case of MMB, while the sleep-promoting supplement glycine only delayed recovery in the case of isoflurane. These results suggest that the simple comparison method is applicable for testing substances expected to exert sleep-inducing effects.
journal_name
J Pharmacol Scijournal_title
Journal of pharmacological sciencesauthors
Murai H,Suzuki H,Tanji H,Kimura T,Iba Ydoi
10.1016/j.jphs.2019.12.003subject
Has Abstractpub_date
2020-02-01 00:00:00pages
79-82issue
2eissn
1347-8613issn
1347-8648pii
S1347-8613(19)35737-8journal_volume
142pub_type
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