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Pharmacological studies on fullerene (C60), a novel carbon allotrope, and its derivatives.

Abstract：

:Fullerene (C(60)), a condensed ring aromatic compound with extended pi systems, is a novel carbon allotrope. Because of its poor solubility in polar solvents, investigation of the biological and pharmacological properties of fullerene has been difficult. Recently, water-soluble fullerene derivatives have been synthesized, and we and others have found that they have potent and selective pharmacological effects on organs, cells, enzymes, and nucleic acids. In the presence of fullerene C(60) derivative (10(-5) M), endothelium-dependent relaxations induced by agonists in the vascular system were eliminated and acetylcholine-induced contractile response of smooth muscle was observed. Some investigators have reported free radical-scavenging activity and direct nitric oxide-quenching activity of fullerene derivatives. Knowledge of the chemical modifications, biological significance, and materials applications of functionalized fullerenes is growing rapidly; and these compounds are emerging as new tools in the field. The focus of this review is to introduce several pharmacological effects of fullerenes and to discuss the possible mechanisms of the pharmacological actions caused by previously synthesized fullerenes.

journal_name

J Pharmacol Sci

journal_title

Journal of pharmacological sciences

authors

Satoh M,Takayanagi I

doi

10.1254/jphs.cpj06002x

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

513-8

issue

5

eissn

1347-8613

issn

1347-8648

pii

JST.JSTAGE/jphs/CPJ06002X

journal_volume

100

pub_type

杂志文章,评审

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