Abstract:
:Cigarette smoking is one of the factors causing accumulation of vascular smooth muscle cells (VSMCs) in atherosclerotic plaques. Changes in cell migration toward platelet-derived growth factor BB were investigated using a Boyden chamber after 48-h preincubation of GBaSM-4 VSMCs with nicotine or nicotine-free cigarette smoke extract (CSE). A nicotine concentration of 0.1 µM maximally promoted cell migration; 0.1% CSE also promoted cell migration, while high CSE concentrations damaged GBaSM-4 cells. Fetal bovine serum (FBS) long-depletion induced decrease in migration of GBaSM-4 cells. Our results suggest that nicotine and some CSE components can induce GBaSM-4 cell migration.
journal_name
J Pharmacol Scijournal_title
Journal of pharmacological sciencesauthors
Yoshiyama S,Horinouchi T,Miwa S,Wang HH,Kohama K,Nakamura Adoi
10.1254/jphs.10283scsubject
Has Abstractpub_date
2011-01-01 00:00:00pages
532-5issue
4eissn
1347-8613issn
1347-8648pii
JST.JSTAGE/jphs/10283SCjournal_volume
115pub_type
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