Effect of aripiprazole on anxiety associated with ethanol physical dependence and on ethanol-induced place preference.

abstract：:Kv1.5 is considered to be a potential molecular target for treatment of atrial fibrillation or flutter. Disopyramide is widely used in the treatment of atrial flutter and/or atrial fibrillation. The present study was undertaken to characterize the effects of disopyramide on currents mediated by Kv1.5 channels and to d...

journal_title：Journal of pharmacological sciences

authors： Aréchiga IA,Barrio-Echavarria GF,Rodríguez-Menchaca AA,Moreno-Galindo EG,Decher N,Tristani-Firouzi M,Sánchez-Chapula JA,Navarro-Polanco RA

更新日期：2008-09-01 00:00:00

abstract：:Peripheral-type benzodiazepine receptor (PBR) and central-type benzodiazepine receptor (CBR) in salivary gland play a role in the inhibitory regulation of salivary secretion in rodents. Diazepam-binding inhibitor (DBI), an endogenous ligand for PBR, produces neurosteroids, which modulate CBR activity. In this study, w...

journal_title：Journal of pharmacological sciences

authors： Tsukagoshi E,Kawaguchi M,Shinomiya T,Yoshikawa M,Kawano T,Okubo M,Sawaki K

更新日期：2011-01-01 00:00:00

abstract：:Androgen-independent prostate cancer (PCa) is a developed tumor derived from the local androgen dependent PCa, which often affects elderly men. Psoralea corylifolia L, a traditional Chinese medicine, has been widely used for PCa treatment as an important part of a common prescription, while the mechanism remains uncle...

journal_title：Journal of pharmacological sciences

authors： Miao L,Yun X,Tao R,Wang Y,Fan G,Zhu Y,Cai T,Zhu Z,Yan C,Gao X

更新日期：2018-09-01 00:00:00

abstract：:Angiotensin II plays an important role in regulating blood pressure. Moreover, angiotensin II directly promotes organ damage by inducing expression of various genes, such as transforming growth factor (TGF)-β and matrix metalloproteinase (MMP)-9 precursors. Blockade of angiotensin II has been shown to not only lower b...

journal_title：Journal of pharmacological sciences

authors： Takai S,Jin D,Miyazaki M

更新日期：2012-01-01 00:00:00

abstract：:There is no direct evidence for the exact cilia-inhibitory effects of opioids, which are generally used to achieve general anesthesia in combination with other anesthetic drugs. These are the reasons, why we analysed direct concentration-dependent or systemic effects of anesthetics (propofol, sufentanil, and midazolam...

journal_title：Journal of pharmacological sciences

authors： Joskova M,Durdik P,Sutovska M,Grendar M,Koniar D,Hargas L,Banovcin P,Franova S

更新日期：2020-04-01 00:00:00

abstract：:The L-type Ca(2+) channel (Ca(V)1.2) shows clear Ca(2+)-dependent facilitation and inactivation. Here we have examined the effects of calmodulin (CaM) and Ca(2+) on Ca(2+) channel in guinea-pig ventricular myocytes in the inside-out patch mode, where rundown of the channels was controlled. At a free [Ca(2+)] of 0.1 mi...

journal_title：Journal of pharmacological sciences

authors： Han DY,Minobe E,Wang WY,Guo F,Xu JJ,Hao LY,Kameyama M

更新日期：2010-01-01 00:00:00

abstract：:Luminal hydrogen sulfide (H(2)S), a gasotransmitter, causes colonic pain / referred hyperalgesia in mice, most probably via activation of T-type Ca(2+) channels. Here we analyzed the mechanisms for H(2)S-induced facilitation of colonic pain signals. Intracolonic administration of NaHS, an H(2)S donor, evoked visceral ...

journal_title：Journal of pharmacological sciences

authors： Tsubota-Matsunami M,Noguchi Y,Okawa Y,Sekiguchi F,Kawabata A

更新日期：2012-01-01 00:00:00

abstract：:System L (SL), a basolateral amino acid transporter, transports large neutral amino acids (LNAAs) in a Na(+)-independent manner. Previously, we identified two isoforms of transporters: L-type amino acid transporter 1 (LAT1) and 2 (LAT2) and revealed their distinct substrate selectivity and transport properties. In thi...

journal_title：Journal of pharmacological sciences

authors： Morimoto E,Kanai Y,Kim DK,Chairoungdua A,Choi HW,Wempe MF,Anzai N,Endou H

更新日期：2008-12-01 00:00:00

abstract：:Ischemia/reperfusion (I/R)-induced oxidative stress is a serious clinical problem in the reperfusion therapy for ischemic diseases. Tumstatin is an endogenous bioactive peptide cleaved from type IV collagen α3 chain. We previously reported that T3 peptide, an active subfragment of tumstatin, exerts cytoprotective effe...

journal_title：Journal of pharmacological sciences

authors： Yasuda J,Okada M,Yamawaki H

更新日期：2019-03-01 00:00:00

abstract：:We investigated the participation of gamma-aminobutyric acid (GABA) neurons of the medial septal area in eight-arm radial maze performance in rats. The intra-septal injection of muscimol, a GABA(A) agonist, caused an increase in total error and working memory error. On the other hand, no significant effect was observe...

journal_title：Journal of pharmacological sciences

authors： Yamamoto Y,Mikami A,Fujii Y,Kamei C

更新日期：2007-07-01 00:00:00

abstract：:High impulsivity will increase the risk of criminal behavior, drug abuse, and suicide. We chose two drugs by following a strategy recently we proposed for identifying potential anti-impulsivity drugs, and examined the effects on impulsive action in rats by using a 3-choice serial reaction time task. We showed that the...

journal_title：Journal of pharmacological sciences

authors： Nishitani N,Sasamori H,Ohmura Y,Yoshida T,Yoshioka M

更新日期：2019-11-01 00:00:00

abstract：:The prevalence rate of cardiovascular disease is higher for males than females, and estradiol (E2) induces AMP-activated protein kinase (AMPK) activation, which is known to regulate proliferation of VSMC. We identified the estrogenic properties of nordihydroguaiaretic acid (NDGA, a lignan phytoestrogen) that inhibit V...

journal_title：Journal of pharmacological sciences

authors： Kim SA,Lee KY,Kim JR,Choi HC

更新日期：2016-09-01 00:00:00

abstract：:Verapamil, a Ca(2+) entry blocker, can induce bronchorelaxation and bronchoconstriction. The mechanism of verapamil-induced bronchoconstriction is poorly understood. The present study determines the direct effect of verapamil on smooth muscle of isolated ovine airways and analyzes the mechanisms involved. Isolated tra...

journal_title：Journal of pharmacological sciences

authors： Mustafa S,Abdulraheem A,Alsughayer A

更新日期：2008-04-01 00:00:00

abstract：:G protein-coupled receptors, in particular, Ca(2+)-mobilizing G(q)-coupled receptors have been reported to be targets for anesthetics. Opioids are commonly used analgesics in clinical practice, but the effects of anesthetics on the opioid mu-receptors (muOR) have not been systematically examined. We report here an ele...

journal_title：Journal of pharmacological sciences

authors： Minami K,Sudo Y,Shiraishi S,Seo M,Uezono Y

更新日期：2010-01-01 00:00:00

abstract：:Multi-glycoside, one of the extracted compounds from Tripterygium wilfordii HOOK. f. (GTW), has been shown to be clinically effective in suppressing glomerular inflammation in chronic kidney disease. However, its clinical application is often limited by its cytotoxic actions on the liver. This study was performed to c...

journal_title：Journal of pharmacological sciences

authors： Wan YG,Zhao Q,Sun W,Zhang HL,Li M,Wei QX,Wu W,Yue LJ,Wang Q

更新日期：2012-01-01 00:00:00

abstract：:To examine effects of volatile anesthetics (VAs) on steroidogenesis, cell suspensions of isolated bovine adrenocortical cells were incubated with several steroidogenic agents in the presence or absence of halothane and sevoflurane. The adrenocortical cells were dispersed by trypsin digestion of bovine adrenal cortex. ...

journal_title：Journal of pharmacological sciences

authors： Masaki E,Shoji K,Saito H,Yamazaki K,Kawamura M

更新日期：2003-10-01 00:00:00

abstract：:GbaSM-4 cells, vascular smooth muscle cells (VSMCs) derived from brain basilar arteries, were shown to migrate toward d-nicotine by augmenting the actin cytoskeleton in their cell bodies and lamellipodia, and expression of nicotinic acetylcholine receptor (alpha7-nAChR) was detected in GbaSM-4 cells. Their chemotaxis ...

journal_title：Journal of pharmacological sciences

authors： Li S,Zhao T,Xin H,Ye LH,Zhang X,Tanaka H,Nakamura A,Kohama K

更新日期：2004-03-01 00:00:00

abstract：:Recent epidemiological studies have demonstrated that coffee drinking is associated with reduced mortality of cardiovascular disease. However, its precise mechanisms remain to be clarified. In this study, we examined whether single ingestion of caffeine contained in a cup of coffee improves microvascular function in h...

journal_title：Journal of pharmacological sciences

authors： Noguchi K,Matsuzaki T,Sakanashi M,Hamadate N,Uchida T,Kina-Tanada M,Kubota H,Nakasone J,Sakanashi M,Ueda S,Masuzaki H,Ishiuchi S,Ohya Y,Tsutsui M

更新日期：2015-02-01 00:00:00

abstract：:Rapid-scanning cofocal microscopy has been applied to the analysis of early phase Ca(2+) transients in ventricular and atrial cardiomyocytes. On electrical stimulation of ventricular myocytes, Ca(2+) concentration begins to rise earliest at the Z-line level and becomes uniform throughout the cytoplasm within about 10 ...

journal_title：Journal of pharmacological sciences

authors： Tanaka H,Kawanishi T,Shigenobu K

更新日期：2003-11-01 00:00:00

abstract：:In this paper, we investigated interactions of the acidic oligosaccharide sugar chain (AOSC), derived from brown algae Echlonia kurome OKAM, with amyloid beta protein (Abeta). We observed that AOSC inhibited the toxicity induced by Abeta in both primarily cortical cells and the SH-SY5Y cell line. We also observed that...

journal_title：Journal of pharmacological sciences

authors： Hu J,Geng M,Li J,Xin X,Wang J,Tang M,Zhang J,Zhang X,Ding J

更新日期：2004-06-01 00:00:00

abstract：:We have developed an in vivo mouse model [the green fluorescent protein (GFP) / carbon tetrachloride (CCl(4)) model] and reported that infused GFP-positive bone marrow cells administered via a tail vein efficiently repopulated cirrhotic liver tissue under conditions of persistent liver damage induced by CCl(4). Moreov...

journal_title：Journal of pharmacological sciences

authors： Takami T,Terai S,Sakaida I

更新日期：2011-01-01 00:00:00

abstract：:Deficiency of tetrahydrobiopterin (BH4) in the vascular tissue contributes to endothelial dysfunction through reduced eNOS activity and increased superoxide anion (O2(-)) generation in the insulin-resistant state. We investigated the effects of atorvastatin, a 3-hydroxyl-3-methylglutaryl coenzyme A (HMG CoA) reductase...

journal_title：Journal of pharmacological sciences

authors： Okamura T,Tawa M,Geddawy A,Shimosato T,Iwasaki H,Shintaku H,Yoshida Y,Masada M,Shinozaki K,Imamura T

更新日期：2014-01-01 00:00:00

abstract：:Bee venom (BV) has been used in patients with rheumatoid arthritis, a condition characterized by rheumatoid joint destruction mediated, in large part, by matrix metalloproteinases (MMPs). We investigated the effects of melittin, a major component of bee venom, on the production of MMPs in human rheumatoid arthritic fi...

journal_title：Journal of pharmacological sciences

authors： Nah SS,Ha E,Mun SH,Won HJ,Chung JH

更新日期：2008-01-01 00:00:00

abstract：:The aim of this study was to classify antiarrhythmic drugs based on their effectiveness on 6 in vivo arrhythmia models, mainly using dogs. The models were produced by two-stage coronary ligation, digitalis, halothane-adrenaline, programmed electrical stimulation in old myocardial infarction dogs, coronary artery occlu...

journal_title：Journal of pharmacological sciences

authors： Hashimoto K

更新日期：2007-04-01 00:00:00

abstract：:Lamotrigine (LTG) is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder and it has been known that LTG targets voltage-dependent sodium channels (VGSCs). In this study, we investigated the effect of LTG on the Nav1.4 Na(+) current using HEK293 cells expressing mouse Nav1.4 VGSCs. By the trea...

journal_title：Journal of pharmacological sciences

authors： Nakatani Y,Masuko H,Amano T

更新日期：2013-01-01 00:00:00

abstract：:Since induced pluripotent stem cells (iPSCs) were generated from mice and humans by Professor Shinya Yamanaka et al. in 2006 and 2007, respectively, a variety of human-derived cells have been generated, including myocardial, liver, retinal pigment epithelial, and neuronal cells. These iPSCs are now used not only in cl...

journal_title：Journal of pharmacological sciences

authors： Nakazawa T,Hashimoto R,Takuma K,Hashimoto H

更新日期：2019-08-01 00:00:00

abstract：:Synaptic transmission is conducted by neurotransmitters released from nerve terminals. Neurotransmitter release is regulated both positively and negatively by multiple mechanisms, and its regulation is believed to be one of the important mechanisms of synaptic plasticity underlying learning and memory. Various protein...

journal_title：Journal of pharmacological sciences

authors： Takahashi M,Itakura M,Kataoka M

更新日期：2003-09-01 00:00:00

abstract：:Saxagliptin, a potent and selective DPP-4 inhibitor, exhibits a slow dissociation from DPP-4. We investigated the sustained effects of saxagliptin on renal DPP-4 activity in a washout study using renal tubular (HK-2) cells, and in a pharmacodynamic study using normal rats. In HK-2 cells, the inhibitory potency of saxa...

journal_title：Journal of pharmacological sciences

authors： Uchii M,Sakai M,Hotta Y,Saeki S,Kimoto N,Hamaguchi A,Kitayama T,Kunori S

更新日期：2017-11-01 00:00:00

abstract：:Lysophosphatidic acid (LPA) initiates demyelination following peripheral nerve injury, which causes neuropathic pain. Our previous in vivo and ex vivo studies using mice have demonstrated that LPA-induced demyelination of spinal dorsal roots is attributed by the LPA1-type receptor-mediated down-regulation of myelin-re...

journal_title：Journal of pharmacological sciences

authors： Tsukahara R,Ueda H

更新日期：2016-10-01 00:00:00

abstract：:The distribution of group I metabotropic glutamate receptors in rat hippocampal cells in culture was examined by calcium imaging and immunocytochemistry. To distinguish different cell types in the culture, the effects of t-ACPD ((1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid) and of NMDA (N-methyl-D-aspartate) were...

journal_title：Journal of pharmacological sciences

authors： Yoshida Y,Matsumoto N,Tsuchiya R,Morita M,Miyakawa H,Kudo Y

更新日期：2003-07-01 00:00:00