Abstract:
:Rapid-scanning cofocal microscopy has been applied to the analysis of early phase Ca(2+) transients in ventricular and atrial cardiomyocytes. On electrical stimulation of ventricular myocytes, Ca(2+) concentration begins to rise earliest at the Z-line level and becomes uniform throughout the cytoplasm within about 10 ms after the onset of the action potential; transsarcolemmal Ca(2+) influx triggers Ca(2+) release from release sites on the junctional sarcoplasmic reticulum (SR) coupled to T-tubules at the Z-line throughout the cytoplasm. In atrial myocytes lacking the T-tubular network, transsarcolemmal Ca(2+) influx during an action potential triggers SR Ca(2+) release only at subsarcolemmal region. SR Ca(2+) release then spreads towards the central region of the cell through a propagated Ca(2+)-induced-Ca(2+) release mechanism. The atrio-ventricular difference in excitation-contraction coupling mechanisms underlies some of the atrio-ventricular difference in response to physiological and pharmacological stimuli.
journal_name
J Pharmacol Scijournal_title
Journal of pharmacological sciencesauthors
Tanaka H,Kawanishi T,Shigenobu Kdoi
10.1254/jphs.93.248subject
Has Abstractpub_date
2003-11-01 00:00:00pages
248-52issue
3eissn
1347-8613issn
1347-8648journal_volume
93pub_type
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