Lipopolysaccharide- and glutamate-induced hypothalamic hydroxyl radical elevation and fever can be suppressed by N-methyl-D-aspartate-receptor antagonists.

abstract：:We examined the effects of a cannabinoid receptor agonist, (R)-(+)-[2,3-dihydro-5-methyl-3-[(4-merpholino)methyl]pyrrolo-[1,2,3-de]-1,4-benzoxazin-6-yl](1-naphthyl)methanone (WIN 55212-2), on various respiratory reactions induced by the activation of capsaicin-sensitive afferent sensory nerves (C-fibers). WIN 55212-2 ...

journal_title：Journal of pharmacological sciences

authors： Yoshihara S,Morimoto H,Ohori M,Yamada Y,Abe T,Arisaka O

更新日期：2005-05-01 00:00:00

abstract：:Nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the incidence of colorectal cancer. However, evidence is accumulating that NSAIDs have anti-cancer effects in addition to inhibiting cyclooxygenase (COX)-mediated prostanoid biosynthesis. We now show that indomethacin, a popular NSAID, significantly reduced the [3H]...

journal_title：Journal of pharmacological sciences

authors： Orido T,Fujino H,Hasegawa Y,Toyomura K,Kawashima T,Murayama T

更新日期：2008-11-01 00:00:00

abstract：:Simultaneous administration of psychostimulants and opioids is a major drug abuse problem worldwide. This combination appears to produce synergistic effects on behavior at low doses; however, there is little direct evidence that the combination is stronger than either drug alone. Therefore, we investigated interaction...

journal_title：Journal of pharmacological sciences

authors： Mori T,Ito S,Narita M,Suzuki T,Sawaguchi T

更新日期：2004-12-01 00:00:00

abstract：:In this study, we clarified the intracellular mechanism of angiotensin II (Ang II) in promoting migration in rat aortic smooth muscle cells (RASMCs). RASMC migration was measured with the Boyden chamber assay, and the result was confirmed with an aortic sprout assay. The activities of kinases were investigated by west...

journal_title：Journal of pharmacological sciences

authors： Lee HM,Lee CK,Lee SH,Roh HY,Bae YM,Lee KY,Lim J,Park PJ,Park TK,Lee YL,Won KJ,Kim B

更新日期：2007-09-01 00:00:00

abstract：:Cisplatin causes chronic interstitial disease with fibrosis, but the development mechanism of interstitial fibrosis is not yet understood. We examined the effect of an antioxidant, N,N'-diphenyl-1,4-phenylenediamine (DPPD), on development of interstitial fibrosis induced by cisplatin. Cisplatin increased blood urea ni...

journal_title：Journal of pharmacological sciences

authors： Kawai Y,Satoh T,Hibi D,Ohno Y,Kohda Y,Miura K,Gemba M

更新日期：2009-12-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPARgamma) is a ligand-dependent nuclear receptor and regulates adipogenesis and fat metabolism. PPARgamma is activated by fatty acid derivatives and some synthetic compounds such as the thiazolidinediones. In addition, certain cytokines were known to affect the transa...

journal_title：Journal of pharmacological sciences

authors： Takada I,Suzawa M,Kato S

更新日期：2005-02-01 00:00:00

abstract：:The pharmacological mechanisms of a synthetic compound 1-benzyl-3-(5'-hydroxymethyl-2'-furyl) indazole (YC-1) in preventing smooth muscle cell proliferation remains to be elucidated. The present study was aimed to explore the effects of YC-1 on certain molecules responsible for cell proliferation, including transformi...

journal_title：Journal of pharmacological sciences

authors： Wu CH,Chang WC,Chang GY,Kuo SC,Teng CM

更新日期：2004-03-01 00:00:00

abstract：:Although mannitol has been used as an osmotherapeutic drug on brain injury, the clinical efficiency of the drug are still controversial. In the present study, we examined the effects of mannitol on the edema in a hippocampal slice due to brief ischemia. To evaluate the effects, we employed an image analysis system tha...

journal_title：Journal of pharmacological sciences

authors： Nakajima R,Nakamura T,Miyakawa H,Kudo Y

更新日期：2004-07-01 00:00:00

abstract：:Alprostadil (lipo-PGE1) is a drug delivery system preparation. This preparation is applied to treat refractory skin ulcers and arteriosclerosis obliterans. We investigated the effects of alprostadil by using the earflap ischemic model. The following results were obtained: 1) Treatment with alprostadil significantly in...

journal_title：Journal of pharmacological sciences

authors： Inoue H,Aihara M,Tomioka M,Watabe Y

更新日期：2013-01-01 00:00:00

abstract：:Pancreatic cancer has remained a major cause of cancer-related deaths. A hallmark of pancreatic cancer is extensive stromal reactions, resulting in a unique tumor microenvironment, especially the involvement of macrophages. These tumor-educated cells limit the efficacy of chemotherapy. Therefore, it is necessary to id...

journal_title：Journal of pharmacological sciences

authors： Wang B,Zheng X,Liu J,Zhang Z,Qiu C,Yang L,Zhang L,Zhang Q,Gao H,Wang X

更新日期：2018-07-01 00:00:00

abstract：:Despite of the huge socio-economic burden, stroke still represents an unmet therapeutic need. Researchers failed to reproduce preclinical efficacy in subsequent clinical development. To bridge this translation failure, the Stroke Therapy Academic Industry Round Table (STAIR) has suggested a rigorous, robust, and detai...

journal_title：Journal of pharmacological sciences

authors： Kaundal RK,Iyer S,Kumar A,Sharma SS

更新日期：2009-03-01 00:00:00

abstract：:Selegiline is used an adjunct to L-DOPA therapy. We investigated extracellular striatal dopamine (DA) level in awake rats treated with L-DOPA and/or selegiline using a microdialysis method. Rats given 10 mg/kg, i.p. per day selegiline for 7 days were administered with a single dose of 100 mg/kg, i.p. L-DOPA 0 (3 h), 1...

journal_title：Journal of pharmacological sciences

authors： Adachi K,Miwa H,Kusumoto H,Shimazu S,Kondo T

更新日期：2006-08-01 00:00:00

abstract：:The aim of this study was to investigate the contribution of gene polymorphisms, in combination with habitual caffeine consumption, to the effect of caffeine intake on hemodynamic and psychoactive parameters. A double-blind, prospective study was conducted with 201 healthy volunteers randomly allocated 2:1 to the caff...

journal_title：Journal of pharmacological sciences

authors： Yoshihara T,Zaitsu M,Shiraishi F,Arima H,Takahashi-Yanaga F,Arioka M,Kajioka S,Sasaguri T

更新日期：2019-03-01 00:00:00

abstract：:Probucol has antioxidant effects and inhibits inflammation. Farnesoid X receptor (FXR) is a nuclear receptor that regulates autophagy, which is regarded as the key cause of the activation of hepatic stellate cell (HSC). In this study, the effects of probucol on HSC activation and autophagy in vitro and vivo and the ro...

journal_title：Journal of pharmacological sciences

authors： Yang R,Hu Z,Zhang P,Wu S,Song Z,Shen X,Wei Z

更新日期：2019-02-01 00:00:00

abstract：:Synaptic transmission is conducted by neurotransmitters released from nerve terminals. Neurotransmitter release is regulated both positively and negatively by multiple mechanisms, and its regulation is believed to be one of the important mechanisms of synaptic plasticity underlying learning and memory. Various protein...

journal_title：Journal of pharmacological sciences

authors： Takahashi M,Itakura M,Kataoka M

更新日期：2003-09-01 00:00:00

abstract：:Metabolic syndrome (MetS) induces serious complications; therefore, we developed a noninvasive MetS model using an extremely small minipig, the Microminipig. For 8 weeks, Microminipigs were administrated a high-fat and high-cholesterol diet (HFCD) for atherosclerosis and N(G)-nitro-l-arginine methyl ester (l-NAME) for...

journal_title：Journal of pharmacological sciences

authors： Yamaguchi T,Yamazaki T,Kawaguchi H,Tawa M,Nakamura Y,Shiota M,Osada-Oka M,Tanimoto A,Okamura T,Miura K,Iwao H,Yoshiyama M,Izumi Y

更新日期：2014-01-01 00:00:00

abstract：:We previously reported that NG108-15 cells contain intrinsic serotonin 2C receptor (5-HT2CR). The effects of imipramine, a 5-HT2CR antagonist, on cell growth, cell viability, and the 5-HT2CR mRNA level were investigated in this study. Repeated treatment with imipramine at concentrations of 1 - 10 microM for 5 days inh...

journal_title：Journal of pharmacological sciences

authors： Sukma M,Tohda M,Watanabe H

更新日期：2003-08-01 00:00:00

abstract：:Melittin is a major peptide component of sweet bee venom that possesses anti-allergic, anti-inflammatory, anti-arthritis, anti-cancer, and neuroprotective properties. However, the therapeutic effects of melittin on muscle injury have not been elucidated. We investigated the therapeutic effects of melittin on muscle in...

journal_title：Journal of pharmacological sciences

authors： Lee JE,Shah VK,Lee EJ,Oh MS,Choi JJ

更新日期：2019-05-01 00:00:00

abstract：:High impulsivity will increase the risk of criminal behavior, drug abuse, and suicide. We chose two drugs by following a strategy recently we proposed for identifying potential anti-impulsivity drugs, and examined the effects on impulsive action in rats by using a 3-choice serial reaction time task. We showed that the...

journal_title：Journal of pharmacological sciences

authors： Nishitani N,Sasamori H,Ohmura Y,Yoshida T,Yoshioka M

更新日期：2019-11-01 00:00:00

abstract：:Evidence has shown that hyperlipidemia is associated with retinoid dyshomeostasis. In liver, retinol is mainly oxidized to retinal by retinol dehydrogenases (RDHs) and alcohol dehydrogenases (ADHs), further converted to retinoic acid by retinal dehydrogenases (RALDHs). The aim of this study was to investigate whether ...

journal_title：Journal of pharmacological sciences

authors： Zhang M,Liu C,Hu MY,Zhang J,Xu P,Li F,Zhong ZY,Liu L,Liu XD

更新日期：2015-04-01 00:00:00

abstract：:Although it is well known that histamine induces gastric mucosal lesions in laboratory animals, the fundamental mechanisms remain unclear. In order to further analyze the vascular mechanisms underlying histamine-induced lesions, a new model was developed in the glandular stomach via administration of histamine (40 mg/...

journal_title：Journal of pharmacological sciences

authors： Amagase K,Okabe S

更新日期：2003-06-01 00:00:00

abstract：:Secretory diarrhea is one of the most common causes of death world-wide especially in children under 5 years old. Isoliquiritigenin (ISLQ), a plant-derived chalcone, has previously been shown to exert anti-secretory action in vitro and in vivo by inhibiting CFTR Cl- channels. However, its CFTR inhibition potency is co...

journal_title：Journal of pharmacological sciences

authors： Yibcharoenporn C,Chusuth P,Jakakul C,Rungrotmongkol T,Chavasiri W,Muanprasat C

更新日期：2019-07-01 00:00:00

abstract：:The purpose of this study was to determine whether carteolol eye drops, a β-adrenoceptor antagonist used as an intraocular hypotensive agent, has protective effects against the light-induced oxidative stress in retina. Dark-adapted pigmented rats were pre-treated with topical carteolol ophthalmic solution or saline an...

journal_title：Journal of pharmacological sciences

authors： Matsuo M,Kuse Y,Takahashi K,Kuwahara K,Tanito M,Kaidzu S,Shimazawa M,Hara H,Ohira A

更新日期：2019-02-01 00:00:00

abstract：:Ischemia/reperfusion (I/R)-induced oxidative stress is a serious clinical problem in the reperfusion therapy for ischemic diseases. Tumstatin is an endogenous bioactive peptide cleaved from type IV collagen α3 chain. We previously reported that T3 peptide, an active subfragment of tumstatin, exerts cytoprotective effe...

journal_title：Journal of pharmacological sciences

authors： Yasuda J,Okada M,Yamawaki H

更新日期：2019-03-01 00:00:00

abstract：:We recently reported that physiological concentrations of 17beta-estradiol partially down-regulate cardiac rapidly-activating delayed rectifier K(+) currents (hERG currents) independently of estrogen-receptor signaling. To determine if other estrogens have the same effect as that of 17beta-estradiol, we investigated r...

journal_title：Journal of pharmacological sciences

authors： Kakusaka S,Asayama M,Kaihara A,Sasano T,Suzuki T,Kurokawa J,Furukawa T

更新日期：2009-01-01 00:00:00

abstract：:To explore memory enhancing effect of the flavonoid fisetin, we investigated the effect of oral administration of flavonoids on the induction of long-term potentiation (LTP) at hippocampal CA1 synapses of anesthetized rats. Among four flavonoids (fisetin, quercetin, luteolin and myricetin) tested, only fisetin signifi...

journal_title：Journal of pharmacological sciences

authors： He WB,Abe K,Akaishi T

更新日期：2018-01-01 00:00:00

abstract：:Neurite outgrowth is a complex differentiation process regulated by external and/or internal mechanisms. Among external mechanisms, G-protein coupled receptors (GPCRs) have been implicated in this process, but the pathways involved are not fully understood. L-3,4-dihydroxyphenylalanine (l-DOPA) is considered to be ine...

journal_title：Journal of pharmacological sciences

authors： Masukawa D,Yamada K,Goshima Y

更新日期：2019-09-01 00:00:00

abstract：:Aristolochic acids (AAs), contained in Chinese herbal preparations, have been considered to induce nephropathy. In order to elucidate the molecular mechanisms of AA-induced nephrotoxicity, we have elucidated the interaction of human organic anion transporters (hOATs) with AAs using their stable cell lines. AA-I and AA...

journal_title：Journal of pharmacological sciences

authors： Babu E,Takeda M,Nishida R,Noshiro-Kofuji R,Yoshida M,Ueda S,Fukutomi T,Anzai N,Endou H

更新日期：2010-01-01 00:00:00

abstract：:Although insulin-resistant states have been associated with endothelial dysfunction due to increased vascular oxidative stress, the underlying mechanisms are pooly understood. Recent experimental evidence suggests that tetrahydrobiopterin (BH(4)), the natural and essential cofactor of NO synthases (NOS), plays a cruci...

journal_title：Journal of pharmacological sciences

authors： Shinozaki K,Kashiwagi A,Masada M,Okamura T

更新日期：2003-03-01 00:00:00

abstract：:Multi-glycoside, one of the extracted compounds from Tripterygium wilfordii HOOK. f. (GTW), has been shown to be clinically effective in suppressing glomerular inflammation in chronic kidney disease. However, its clinical application is often limited by its cytotoxic actions on the liver. This study was performed to c...

journal_title：Journal of pharmacological sciences

authors： Wan YG,Zhao Q,Sun W,Zhang HL,Li M,Wei QX,Wu W,Yue LJ,Wang Q

更新日期：2012-01-01 00:00:00