Indomethacin decreases arachidonic acid uptake in HCA-7 human colon cancer cells.

Abstract:

:Nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the incidence of colorectal cancer. However, evidence is accumulating that NSAIDs have anti-cancer effects in addition to inhibiting cyclooxygenase (COX)-mediated prostanoid biosynthesis. We now show that indomethacin, a popular NSAID, significantly reduced the [3H]-arachidonic acid uptake in HCA-7 human colon cancer cells. Interestingly, no decrease in the uptake of [3H]-arachidonic acid occurred when the cells were treated with aspirin, diclofenac, and sulindac even though the concentrations of these NSAIDs were high enough to inhibit COX-2 activity. These findings suggest that indomethacin has a novel anti-cancer effect that may be independent of COX-2 inhibition.

journal_name

J Pharmacol Sci

authors

Orido T,Fujino H,Hasegawa Y,Toyomura K,Kawashima T,Murayama T

doi

10.1254/jphs.08167sc

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

389-92

issue

3

eissn

1347-8613

issn

1347-8648

pii

JST.JSTAGE/jphs/08167SC

journal_volume

108

pub_type

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