Abstract:
:We previously reported that NG108-15 cells contain intrinsic serotonin 2C receptor (5-HT2CR). The effects of imipramine, a 5-HT2CR antagonist, on cell growth, cell viability, and the 5-HT2CR mRNA level were investigated in this study. Repeated treatment with imipramine at concentrations of 1 - 10 microM for 5 days inhibited cell growth in a concentration-dependent manner without affecting cell viability. In addition, the level of 5-HT2CR mRNA was elevated. At 30 microM, imipramine significantly reduced cell viability. Our findings suggest that the effect of imipramine on neuronal growth may be related to its effects on 5-HT2CR.
journal_name
J Pharmacol Scijournal_title
Journal of pharmacological sciencesauthors
Sukma M,Tohda M,Watanabe Hdoi
10.1254/jphs.92.433subject
Has Abstractpub_date
2003-08-01 00:00:00pages
433-6issue
4eissn
1347-8613issn
1347-8648journal_volume
92pub_type
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