Protective effects of phytochemical antioxidants against neurotoxin-induced degeneration of dopaminergic neurons.


:The specific toxicity to dopaminergic neurons of psychostimulants and neurotoxins has been extensively studied in vivo and in vitro, and findings have been used to establish animal models of amphetamine psychosis or Parkinson's disease. The multiple mechanisms of neurotoxicity operating in these disorders are known to involve oxidative stress or neuroinflammation, producing the characteristic behavioral and neuropathlogical changes arising from injured dopaminergic neurons and glial cells. A number of studies have shown that glia-targeting antioxidants play important roles in protecting against the neurotoxicity caused by psychostimulants or neurotoxins. Phytochemicals, which are non-nutritive plant chemicals, protect dopaminergic neurons and glial cells from damage caused by psychostimulants or neurotoxins. The objective of this review was to evaluate the involvement of glial cells in dopaminergic neuron-specific toxicity and to explore the neuroprotective activity of phytochemicals in terms of anti-inflammatory and antioxidant action.


J Pharmacol Sci


Kita T,Asanuma M,Miyazaki I,Takeshima M




Has Abstract


2014-01-01 00:00:00














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    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章


    authors: Iuchi K,Akagi K,Yagura T

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  • Neurotoxin A2NTX Blocks Fast Inhibitory and Excitatory Transmitter Release From Presynaptic Terminals.

    abstract::Our recent study showed a possibility that newly developed A2 type botulinum toxin (A2NTX) inhibits both spontaneous and evoked transmitter release from inhibitory (glycinergic or GABAergic) and excitatory (glutamatergic) nerve terminals using rat spinal sacral dorsal commissural nucleus neurons. In the present study,...

    journal_title:Journal of pharmacological sciences

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    authors: Yamaga T,Aou S,Shin MC,Wakita M,Akaike N

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    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章


    authors: Ren Y,Xu X,Wang X

    更新日期:2003-12-01 00:00:00

  • Endothelial progenitor cells: therapeutic target for cardiovascular diseases.

    abstract::Circulating endothelial progenitor cells (EPCs) derived from bone marrow were isolated for the first time in 1997 and characterized. Recent evidence has indicated that EPCs contribute to re-endothelialization of injured vessels as well as neovascularization of ischemic lesions and that a decrease in the number of EPCs...

    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章,评审


    authors: Umemura T,Higashi Y

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  • Lig-8, a bioactive lignophenol derivative from bamboo lignin, protects against neuronal damage in vitro and in vivo.

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    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章


    authors: Ito Y,Shimazawa M,Akao Y,Nakajima Y,Seki N,Nozawa Y,Hara H

    更新日期:2006-10-01 00:00:00

  • A comparative pharmacology study between the intracolonic and oral routes of 5-FU administration in a colon cancer-bearing Yoshida sarcoma rat model.

    abstract::We prepared a colon cancer-bearing Yoshida sarcoma rat model to examine the dose-response relationship of antitumor activity of intracolonically or orally administered 5-fluorouracil (5-FU; 45, 30, 20, 13, and 8 mg/kg). At doses of > or =20 mg/kg and > or =30 mg/kg, the 5-FU intracolonic and oral administration groups...

    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章


    authors: Goto T,Tomizawa N,Kobayashi E,Fujimura A

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  • Cucurbitacin B induces inhibitory effects via the CIP2A/PP2A/C-KIT signaling axis in t(8;21) acute myeloid leukemia.

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    journal_title:Journal of pharmacological sciences

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    authors: Ma W,Xiang Y,Yang R,Zhang T,Xu J,Wu Y,Liu X,Xiang K,Zhao H,Liu Y,Si Y

    更新日期:2019-04-01 00:00:00

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    journal_title:Journal of pharmacological sciences

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    authors: Sharifi AM,Mousavi SH,Farhadi M,Larijani B

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    journal_title:Journal of pharmacological sciences

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    authors: Yamaguchi Y,Takeda K,Hino M

    更新日期:2013-01-01 00:00:00

  • A simple in vivo atrial fibrillation model of rat induced by transesophageal atrial burst pacing.

    abstract::A simple in vivo closed-chest atrial fibrillation (Af) model of rats was developed. Af was reproducibly induced by transesophageal atrial burst pacing for 30 s in each of the pentobarbital-anesthetized rats, whereas the cardiohemodynamic condition as well as the inducibility and duration of Af episode was stable over ...

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    authors: Sugiyama A,Takahara A,Honsho S,Nakamura Y,Hashimoto K

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    journal_title:Journal of pharmacological sciences

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    authors: Agharkar AS,Gonzales EB

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    pub_type: 杂志文章,随机对照试验


    authors: Yoshihara T,Zaitsu M,Shiraishi F,Arima H,Takahashi-Yanaga F,Arioka M,Kajioka S,Sasaguri T

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    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Mori T,Ito S,Narita M,Suzuki T,Sawaguchi T

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    journal_title:Journal of pharmacological sciences

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    authors: Yu J,Li X,Tashiro S,Onodera S,Ikejima T

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    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章


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    journal_title:Journal of pharmacological sciences

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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Ishii T,Nishimura K,Nishimura M

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    pub_type: 杂志文章


    authors: Yamanishi T,Kaga K,Fuse M,Shibata C,Kamai T,Uchiyama T

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    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章


    authors: Silici S,Koç NA,Ayangil D,Cankaya S

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  • Inhibition of the TNF-α-induced serine phosphorylation of IRS-1 at 636/639 by AICAR.

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    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章


    authors: Shibata T,Takaguri A,Ichihara K,Satoh K

    更新日期:2013-01-01 00:00:00

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    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章


    authors: Wu CH,Chang WC,Chang GY,Kuo SC,Teng CM

    更新日期:2004-03-01 00:00:00

  • On the mechanisms underlying histamine induction of gastric mucosal lesions in rats with partial gastric vascular occlusion.

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    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章


    authors: Amagase K,Okabe S

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    journal_title:Journal of pharmacological sciences

    pub_type: 杂志文章


    authors: Kao CH,Kao TY,Huang WT,Lin MT

    更新日期:2007-06-01 00:00:00