Abstract:
:Lysophosphatidic acid (LPA), the simplest of the water-soluble phospholipids, can evoke various biological responses. The present study examined the activity of LPA to induce plasma exudation and histamine release in mice. Plasma exudation was assessed by extravasation of Evans blue. Subcutaneous administration of LPA (1 - 100 microg/site) led to increased plasma exudation in the skin. The LPA-induced plasma exudation was inhibited by ketotifen, a histamine H1-receptor antagonist, and diacylglycerol pyrophosphate (DGPP), a LPA1/LPA3-receptor antagonist. Moreover, pretreatment with pertussis toxin and DGPP inhibited the histamine release from peritoneal mast cells induced by LPA. These findings indicate that plasma exudation induced by LPA is mediated by histamine release from mast cells via LPA receptor(s), presumably LPA1 and/or LPA3, coupled to G(i/o) proteins. Moreover, these findings point to a role of LPA in the pathomechanisms of various allergic disorders.
journal_name
J Pharmacol Scijournal_title
Journal of pharmacological sciencesauthors
Hashimoto T,Ohata H,Honda Kdoi
10.1254/jphs.fpj05030xsubject
Has Abstractpub_date
2006-01-01 00:00:00pages
82-7issue
1eissn
1347-8613issn
1347-8648pii
JST.JSTAGE/jphs/FPJ05030Xjournal_volume
100pub_type
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