New methods to evaluate endothelial function: A search for a marker of nitric oxide (NO) in vivo: re-evaluation of NOx in plasma and red blood cells and a trial to detect nitrosothiols.

abstract：:It has been widely accepted that macrophages are divided into M1 "pro-inflammatory" macrophages and M2 "anti-inflammatory" macrophages and an uncontrolled macrophage polarization plays an important role in the pathogenesis of different diseases. As the main substance of total glucosides of peony, paeoniflorin (PF), ha...

journal_title：Journal of pharmacological sciences

authors： Zhai T,Sun Y,Li H,Zhang J,Huo R,Li H,Shen B,Li N

更新日期：2016-03-01 00:00:00

abstract：:The optimum strategy for heart failure (HF) treatment has yet to be elucidated. This study intended to test the benefit of a combination of valsartan (VAL) and perifosine (PER), a specific AKT inhibitor, in protecting against pressure overload induced mouse HF. Mouse were subjected to aortic banding (AB) surgery to es...

journal_title：Journal of pharmacological sciences

authors： Li WJ,Liao HH,Feng H,Zhou ZY,Mou SQ,Zhang N,Wu HM,Xia H,Tang QZ

更新日期：2020-07-01 00:00:00

abstract：:Five isoforms of Na+/Ca2+ exchanger have been identified: NCX1, NCX2, NCX3, NCX-SQ1, and CALX. In all of the exchangers, the Na+/Ca2+ exchange current, which was recorded in inside-out membrane patches, was regulated by cytoplasmic Ca2+. However, the mode of regulation is different among the exchangers. NCX1, NCX2, an...

journal_title：Journal of pharmacological sciences

authors： Matsuoka S

更新日期：2004-09-01 00:00:00

abstract：:Oleoylethanolamine (OEA), an endogenous high-affinity agonist of peroxisome proliferator-activated receptor alpha (PPAR-α), has revealed the pharmacological properties in the treatment of obesity, atherosclerosis and other diseases through the modulation of lipid metabolism. To assess whether OEA can also regulate non...

journal_title：Journal of pharmacological sciences

authors： Li L,Li L,Chen L,Lin X,Xu Y,Ren J,Fu J,Qiu Y

更新日期：2015-03-01 00:00:00

abstract：:The GABAergic system in the spinal cord has been shown to participate in neuropathic pain in various animal models. GABA transporters (GATs) play a role in controlling the synaptic clearance of GABA; however, their role in neuropathic pain remains unclear. In the present study, we compared the betaine/GABA transporter...

journal_title：Journal of pharmacological sciences

authors： Jinzenji A,Sogawa C,Miyawaki T,Wen XF,Yi D,Ohyama K,Kitayama S,Sogawa N,Morita K

更新日期：2014-01-01 00:00:00

abstract：:Cimetidine is known to suppress the growth of several tumors, including gastrointestinal cancer, in humans and animals. Nonetheless, whether other histamine H(2)-receptor antagonists exert such tumor suppressive effects remains unclear. The effect of roxatidine acetate hydrochloride (roxatidine), an H(2)-receptor anta...

journal_title：Journal of pharmacological sciences

authors： Tomita K,Izumi K,Okabe S

更新日期：2003-11-01 00:00:00

abstract：:2-Aminophenoxazine-3-one (Phx-3) induced cellular apoptosis in mouse melanoma B16 cells as detected by DNA laddering and upregulated Fas expression in the cells in vitro. Next, the anti-metastatic effects of Phx-3 were investigated in C56BL/6 mice. When B16 melanoma cells were injected into the tail veins of mice, sig...

journal_title：Journal of pharmacological sciences

authors： Hongo T,Miyano-Kurosaki N,Kurosaki K,Hata A,Harigae S,Tomoda A

更新日期：2010-01-01 00:00:00

abstract：:Differences of cell proliferation, cell cycle, and G(1)/S transition regulatory proteins of gingival fibroblasts derived from nifedipine-reactive patient (NIFr) and nifedipine-non-reactive patient (NIFn) in the presence of basic fibroblast growth factor (bFGF) were investigated to elucidate the mechanism of gingival o...

journal_title：Journal of pharmacological sciences

authors： Takeuchi R,Matsumoto H,Okada H,Hori M,Gunji A,Hakozaki K,Akimoto Y,Fujii A

更新日期：2007-02-01 00:00:00

abstract：:Functional dyspepsia (FD) is thought to be mainly based on gastric motility dysfunction and chronic hypersensitivity, yet FD animal models has been reported a few. We studied to establish the mouse model of impaired gastric motility induced by a pungent ingredient of wasabi allyl isothiocyanate (AITC), which is reliab...

journal_title：Journal of pharmacological sciences

authors： Hashimoto K,Tashima K,Imai T,Matsumoto K,Horie S

更新日期：2021-01-01 00:00:00

abstract：:Lysophosphatidic acid (LPA), the simplest of the water-soluble phospholipids, can evoke various biological responses. The present study examined the activity of LPA to induce plasma exudation and histamine release in mice. Plasma exudation was assessed by extravasation of Evans blue. Subcutaneous administration of LPA...

journal_title：Journal of pharmacological sciences

authors： Hashimoto T,Ohata H,Honda K

更新日期：2006-01-01 00:00:00

abstract：:We investigated the anti-vasospastic potential of fasudil's active metabolite, hydroxyfasudil, a Rho-kinase inhibitor, after subarachnoid hemorrhage (SAH) and also its effect on hemorheological abnormalities following cerebral ischemia. Chronic cerebral vasospasm was produced using a two-hemorrhage canine model. On da...

journal_title：Journal of pharmacological sciences

authors： Satoh S,Takayasu M,Kawasaki K,Ikegaki I,Hitomi A,Yano K,Shibuya M,Asano T

更新日期：2012-01-01 00:00:00

abstract：:Based on the structure of AAP, a novel anti-thrombotic peptide from snake venom which we discovered in our previous study, more than 60 compounds were designed and synthesized. One of these termed as LX0702 exhibited stronger anti-platelet aggregation activity than AAP. This study aims to investigate the effects of LX...

journal_title：Journal of pharmacological sciences

authors： Kong Y,Wang Y,Yang W,Xie Z,Li Z

更新日期：2015-04-01 00:00:00

abstract：:We recently reported that physiological concentrations of 17beta-estradiol partially down-regulate cardiac rapidly-activating delayed rectifier K(+) currents (hERG currents) independently of estrogen-receptor signaling. To determine if other estrogens have the same effect as that of 17beta-estradiol, we investigated r...

journal_title：Journal of pharmacological sciences

authors： Kakusaka S,Asayama M,Kaihara A,Sasano T,Suzuki T,Kurokawa J,Furukawa T

更新日期：2009-01-01 00:00:00

abstract：:In the present study, we investigated the effect of aripiprazole, a dopamine system stabilizer, on ethanol-induced psychological and physiological dependence and anxiety-like behavior. First we determined the effect of aripiprazole, a dopamine system stabilizer, on the development and expression of ethanol-induced pla...

journal_title：Journal of pharmacological sciences

authors： Shibasaki M,Kurokawa K,Mizuno K,Ohkuma S

更新日期：2012-01-01 00:00:00

abstract：:Our recent study showed a possibility that newly developed A2 type botulinum toxin (A2NTX) inhibits both spontaneous and evoked transmitter release from inhibitory (glycinergic or GABAergic) and excitatory (glutamatergic) nerve terminals using rat spinal sacral dorsal commissural nucleus neurons. In the present study,...

journal_title：Journal of pharmacological sciences

authors： Yamaga T,Aou S,Shin MC,Wakita M,Akaike N

更新日期：2012-01-01 00:00:00

abstract：:Cytochrome P450 (CYP) catalyzes the oxidation of many endogenous and xenobiotic compounds. The expression of CYP isozymes are modulated by endogenous hormones and xenobiotics. We found that, although CYP2C11 and CYP3A2 are adult male-specific isozymes, they are also expressed in prepubertal female Sprague Dawley (SD) ...

journal_title：Journal of pharmacological sciences

authors： Ishii T,Nishimura K,Nishimura M

更新日期：2006-07-01 00:00:00

abstract：:The mesocorticolimbic dopaminergic system plays an important role in the reinforcing effects of drugs of abuse, and the activity-dependent synaptic plasticity of the system is involved in drug dependence. A DNA microarray screening revealed that the expression levels of tissue plasminogen activator (tPA) mRNA in the n...

journal_title：Journal of pharmacological sciences

authors： Yamada K,Nagai T,Nabeshima T

更新日期：2005-02-01 00:00:00

abstract：:We investigated the effects of gabapentin and pregabalin on the itch-associated response in a mouse model of chronic dermatitis induced by the repeated application of 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one (oxazolone). Challenging the mice with oxazolone-induced chronic dermatitis with the oxazolone evoked severe...

journal_title：Journal of pharmacological sciences

authors： Tsukumo Y,Matsumoto Y,Miura H,Yano H,Manabe H

更新日期：2011-01-01 00:00:00

abstract：:Pseudolaric acid B (PAB) exerted cytostatic activity on murine fibrosarcoma L929 cells. The cytostatic mechanism of PAB on L929 cells was investigated in this paper. At 36 h, after 80 microM PAB treatment, the inhibitory ratio was 65.37 +/- 4.12%, and the MDC staining ratio was strongest in L929 cells. 3-Methyladenine...

journal_title：Journal of pharmacological sciences

authors： Yu J,Li X,Tashiro S,Onodera S,Ikejima T

更新日期：2008-07-01 00:00:00

abstract：:In this paper, we investigated interactions of the acidic oligosaccharide sugar chain (AOSC), derived from brown algae Echlonia kurome OKAM, with amyloid beta protein (Abeta). We observed that AOSC inhibited the toxicity induced by Abeta in both primarily cortical cells and the SH-SY5Y cell line. We also observed that...

journal_title：Journal of pharmacological sciences

authors： Hu J,Geng M,Li J,Xin X,Wang J,Tang M,Zhang J,Zhang X,Ding J

更新日期：2004-06-01 00:00:00

abstract：:In the present study, we investigated the protective effect of methyl 3,4-dihydroxybenzoate (MDHB) against H2O2-induced apoptosis in RGC-5 cells. The RGC-5 cells were cultured in plates for 24 h, which were then pretreated with dimethyl sulfoxide, different concentrations of MDHB, or probucol for 12 h prior to additio...

journal_title：Journal of pharmacological sciences

authors： Zhou X,Su CF,Zhang Z,Wang CY,Luo JQ,Zhou XW,Cai L,Yan L,Zhang W,Luo HM

更新日期：2014-01-01 00:00:00

abstract：:The hippocampus is a brain region well-known to exhibit structural and functional changes in temporal lobe epilepsy. Studies analyzing the brains of patients with epilepsy and those from animal models of epilepsy have revealed that microglia are excessively activated, especially in the hippocampus. These findings sugg...

journal_title：Journal of pharmacological sciences

authors： Andoh M,Ikegaya Y,Koyama R

更新日期：2020-12-01 00:00:00

abstract：:The distribution of group I metabotropic glutamate receptors in rat hippocampal cells in culture was examined by calcium imaging and immunocytochemistry. To distinguish different cell types in the culture, the effects of t-ACPD ((1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid) and of NMDA (N-methyl-D-aspartate) were...

journal_title：Journal of pharmacological sciences

authors： Yoshida Y,Matsumoto N,Tsuchiya R,Morita M,Miyakawa H,Kudo Y

更新日期：2003-07-01 00:00:00

abstract：:Peripheral-type benzodiazepine receptor (PBR) and central-type benzodiazepine receptor (CBR) in salivary gland play a role in the inhibitory regulation of salivary secretion in rodents. Diazepam-binding inhibitor (DBI), an endogenous ligand for PBR, produces neurosteroids, which modulate CBR activity. In this study, w...

journal_title：Journal of pharmacological sciences

authors： Tsukagoshi E,Kawaguchi M,Shinomiya T,Yoshikawa M,Kawano T,Okubo M,Sawaki K

更新日期：2011-01-01 00:00:00

abstract：:Androgen-independent prostate cancer (PCa) is a developed tumor derived from the local androgen dependent PCa, which often affects elderly men. Psoralea corylifolia L, a traditional Chinese medicine, has been widely used for PCa treatment as an important part of a common prescription, while the mechanism remains uncle...

journal_title：Journal of pharmacological sciences

authors： Miao L,Yun X,Tao R,Wang Y,Fan G,Zhu Y,Cai T,Zhu Z,Yan C,Gao X

更新日期：2018-09-01 00:00:00

abstract：:Although mannitol has been used as an osmotherapeutic drug on brain injury, the clinical efficiency of the drug are still controversial. In the present study, we examined the effects of mannitol on the edema in a hippocampal slice due to brief ischemia. To evaluate the effects, we employed an image analysis system tha...

journal_title：Journal of pharmacological sciences

authors： Nakajima R,Nakamura T,Miyakawa H,Kudo Y

更新日期：2004-07-01 00:00:00

abstract：:The G protein-coupled receptors (GPCRs) form the largest and the most versatile superfamily that share a seven-transmembrane-spanning architecture. GPCR-signaling is involved in vision, taste, olfaction, sympathetic/parasympathetic nervous functions, metabolism, and immune regulation, indicating that GPCRs are extreme...

journal_title：Journal of pharmacological sciences

authors： Miyano K,Sudo Y,Yokoyama A,Hisaoka-Nakashima K,Morioka N,Takebayashi M,Nakata Y,Higami Y,Uezono Y

更新日期：2014-01-01 00:00:00

abstract：:Type 1 regulatory T (Tr1) cells are CD4+ T cells that produce a large amount of IL-10, an anti-inflammatory cytokine. However, it has not been fully elucidated whether Tr1 cells suppress allergic asthma. In this study, the effects of adoptive transfer of in vitro-induced Tr1 cells on allergic asthma were evaluated. Sp...

journal_title：Journal of pharmacological sciences

authors： Matsuda M,Doi K,Tsutsumi T,Inaba M,Hamaguchi J,Terada T,Kawata R,Kitatani K,Nabe T

更新日期：2019-12-01 00:00:00

abstract：:We prepared a colon cancer-bearing Yoshida sarcoma rat model to examine the dose-response relationship of antitumor activity of intracolonically or orally administered 5-fluorouracil (5-FU; 45, 30, 20, 13, and 8 mg/kg). At doses of > or =20 mg/kg and > or =30 mg/kg, the 5-FU intracolonic and oral administration groups...

journal_title：Journal of pharmacological sciences

authors： Goto T,Tomizawa N,Kobayashi E,Fujimura A

更新日期：2004-06-01 00:00:00

abstract：:Forsythiae Fructus is known to have diuretic, anti-bacterial, and anti-inflammatory activities. This study examined the hepatoprotective effects of pinoresinol, a lignan isolated from Forsythiae Fructus, against carbon tetrachloride (CCl(4))-induced liver injury. Mice were treated intraperitoneally with vehicle or pin...

journal_title：Journal of pharmacological sciences

authors： Kim HY,Kim JK,Choi JH,Jung JY,Oh WY,Kim DC,Lee HS,Kim YS,Kang SS,Lee SH,Lee SM

更新日期：2010-01-01 00:00:00