Bcl-2 family proteins were involved in pseudolaric acid B-induced autophagy in murine fibrosarcoma L929 cells.

abstract：:Electropharmacological effect of the antipsychotic and antiemetic drug prochlorperazine was assessed using the halothane-anesthetized in vivo canine model (n = 5). Up to 10 times higher than the clinically relevant doses of prochlorperazine (< or = 3 mg/kg, i.v.) did not induce cardiohemodynamic collapse in the model....

journal_title：Journal of pharmacological sciences

authors： Satoh Y,Sugiyama A,Takahara A,Ando K,Wang K,Honsho S,Hashimoto K

更新日期：2005-01-01 00:00:00

abstract：:We have shown that coadministration of sulpiride and fluvoxamine preferentially increases the release of dopamine in the prefrontal cortex. To study the possible role of the cortical cholinergic system in this effect, we combined several other antipsychotic drugs with fluvoxamine and examined the effects on acetylchol...

journal_title：Journal of pharmacological sciences

authors： Ago Y,Sato M,Nakamura S,Baba A,Matsuda T

更新日期：2006-12-01 00:00:00

abstract：:There is no direct evidence for the exact cilia-inhibitory effects of opioids, which are generally used to achieve general anesthesia in combination with other anesthetic drugs. These are the reasons, why we analysed direct concentration-dependent or systemic effects of anesthetics (propofol, sufentanil, and midazolam...

journal_title：Journal of pharmacological sciences

authors： Joskova M,Durdik P,Sutovska M,Grendar M,Koniar D,Hargas L,Banovcin P,Franova S

更新日期：2020-04-01 00:00:00

abstract：:Kursi Wufarikun Ziyabit (KWZ) is a traditional prescription that used in folk tea drinking for its health care effect in treatment of type 2 diabetes mellitus (T2DM) in central Asia. However, the underlying mechanism of KWZ in T2DM has not been investigated extensively. This study designed to observe the effect of KWZ...

journal_title：Journal of pharmacological sciences

authors： Edirs S,Jiang L,Xin X,Aisa HA

更新日期：2018-06-01 00:00:00

abstract：:Endothelin type A receptor (ETAR) is internalized upon agonist stimulation; however, the mechanism thereof remains controversial. In this study, we characterized the endothelin-1 (ET-1)-induced internalization of ETAR expressed in Chinese hamster ovary cells. ET-1 elicited ETAR internalization and increase in intracel...

journal_title：Journal of pharmacological sciences

authors： Horinouchi T,Karki S,Terada K,Mazaki Y,Miwa S

更新日期：2019-05-01 00:00:00

abstract：:Secretory diarrhea is one of the most common causes of death world-wide especially in children under 5 years old. Isoliquiritigenin (ISLQ), a plant-derived chalcone, has previously been shown to exert anti-secretory action in vitro and in vivo by inhibiting CFTR Cl- channels. However, its CFTR inhibition potency is co...

journal_title：Journal of pharmacological sciences

authors： Yibcharoenporn C,Chusuth P,Jakakul C,Rungrotmongkol T,Chavasiri W,Muanprasat C

更新日期：2019-07-01 00:00:00

abstract：:In the present study, we investigated whether a novel benzopyranylindol analogue, KR-31466 (KR466) (1-[(2S,3R,4S)-3,4-dihydro-2-dimethoxymethyl-3-hydroxy-2-methyl-6-nitro-2H-1-benzopyran-4-yl]-1H-indole-2-carboxylic acid ethyl ester) can attenuate hypoxic injury in heart-derived H9c2 cells and, if so, whether the prot...

journal_title：Journal of pharmacological sciences

authors： Jung YS,Jung YS,Kim MY,Kim MH,Lee S,Yi KY,Yoo SE,Lee SH,Baik EJ,Moon CH,Cho JP

更新日期：2003-05-01 00:00:00

abstract：:The distribution of group I metabotropic glutamate receptors in rat hippocampal cells in culture was examined by calcium imaging and immunocytochemistry. To distinguish different cell types in the culture, the effects of t-ACPD ((1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid) and of NMDA (N-methyl-D-aspartate) were...

journal_title：Journal of pharmacological sciences

authors： Yoshida Y,Matsumoto N,Tsuchiya R,Morita M,Miyakawa H,Kudo Y

更新日期：2003-07-01 00:00:00

abstract：:This study investigated endogenous mediators involved in mosquito allergy-associated itching in mice. An intradermal injection of an extract of mosquito salivary gland elicited marked scratching in sensitized mice. The 5-lipoxygenase inhibitor zileuton (100 mg/kg), the 5-lipoxygenase activating peptide inhibitor MK-88...

journal_title：Journal of pharmacological sciences

authors： Kuraishi Y,Ohtsuka E,Nakano T,Kawai S,Andoh T,Nojima H,Kamimura K

更新日期：2007-09-01 00:00:00

abstract：:Cardiovascular diseases are the most frequent and costly complication of diabetes. Many previous studies showed that ATP-sensitive potassium channels (K(ATP)) and inward rectifier potassium channels (Kir) play important regulatory roles in functions of cardiovascular tissues. It's still not very clear how these potass...

journal_title：Journal of pharmacological sciences

authors： Ren Y,Xu X,Wang X

更新日期：2003-12-01 00:00:00

abstract：:The aim of this study was to characterize the effects of rebamipide on the oxidative burst of human neutrophils. The neutrophil oxidative burst was measured in the presence of rebamipide and cimetidine using lucigenin- or luminol-dependent chemiluminescence (LgCL or LmCL). Rebamipide inhibited the LmCL response stimul...

journal_title：Journal of pharmacological sciences

authors： Shimoyama T,Fukuda S,Liu Q,Fukuda Y,Nakaji S,Sugawara K

更新日期：2003-02-01 00:00:00

abstract：:The aim of this study was to compare the effect of antimuscarinic antagonists on carbachol-induced contraction of normal human bladder and detrusor overactivity associated with benign prostatic hyperplasia (DO/BPH). Samples of human bladder muscle were obtained from patients undergoing total cystectomy for bladder can...

journal_title：Journal of pharmacological sciences

authors： Yamanishi T,Kaga K,Fuse M,Shibata C,Kamai T,Uchiyama T

更新日期：2015-06-01 00:00:00

abstract：:Although the opioid system is known to modulate depression-like behaviors, its role in the effects of antidepressants is not yet clear. We investigated the role of μ-opioid receptors (MOPs) in the effects of venlafaxine, a serotonin and norepinephrine reuptake inhibitor, in the forced swim test using MOP-knockout (KO)...

journal_title：Journal of pharmacological sciences

authors： Ide S,Fujiwara S,Fujiwara M,Sora I,Ikeda K,Minami M,Uhl GR,Ishihara K

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Clinical efficacy of allergen-specific Immunotherapy (AIT) towards Japanese cedar (JC) pollen allergy is firmly established but JC pollen-specific biomarker assays are lacking. Treatment-related increase of allergen-specific antibodies is a robust biomarker of successful AIT. Allergen-specific non-IgE antibo...

journal_title：Journal of pharmacological sciences

authors： Fukano C,Ohashi-Doi K,Lund K,Nakao A,Masuyama K,Matsuoka T

更新日期：2019-07-01 00:00:00

abstract：:The mesocorticolimbic dopaminergic system plays an important role in the reinforcing effects of drugs of abuse, and the activity-dependent synaptic plasticity of the system is involved in drug dependence. A DNA microarray screening revealed that the expression levels of tissue plasminogen activator (tPA) mRNA in the n...

journal_title：Journal of pharmacological sciences

authors： Yamada K,Nagai T,Nabeshima T

更新日期：2005-02-01 00:00:00

abstract：:Yeasts isolated from patients with superficial mycoses were tested against propolis samples collected from different regions and honeybee races. The minimum inhibitory concentration (MIC) values obtained using the agar dilution methods were compared to the diameters of growth inhibition zones by using the disk diffusi...

journal_title：Journal of pharmacological sciences

authors： Silici S,Koç NA,Ayangil D,Cankaya S

更新日期：2005-09-01 00:00:00

abstract：:To ascertain whether steroid therapy evokes dentin hypersensitivity (DH)-like tooth pain, we performed a study based on compelling evidence from patients receiving steroid therapy. An exploratory study was conducted using a questionnaire for 220 patients prescribed steroids who attended the Department of Hematology an...

journal_title：Journal of pharmacological sciences

authors： Shoji N,Endo Y,Iikubo M,Ishii T,Harigae H,Aida J,Sakamoto M,Sasano T

更新日期：2016-11-01 00:00:00

abstract：:It has been widely accepted that macrophages are divided into M1 "pro-inflammatory" macrophages and M2 "anti-inflammatory" macrophages and an uncontrolled macrophage polarization plays an important role in the pathogenesis of different diseases. As the main substance of total glucosides of peony, paeoniflorin (PF), ha...

journal_title：Journal of pharmacological sciences

authors： Zhai T,Sun Y,Li H,Zhang J,Huo R,Li H,Shen B,Li N

更新日期：2016-03-01 00:00:00

abstract：:Resveratrol is a stilbene compound found in grapes and other sources. In this study we examined the effects of trans-resveratrol (4.38 - 438 microM/implant) in the vasculogenesis of yolk-sac membranes and its capacity to improve chick embryo growth. High concentrations of the stilbene (43.8 - 438 microM) significantly...

journal_title：Journal of pharmacological sciences

authors： Dias PF,Berti FV,Siqueira JM Jr,Maraschin M,Gagliardi AR,Ribeiro-do-Valle RM

更新日期：2008-06-01 00:00:00

abstract：:A segment of guinea pig ileum was used to confirm the hypothesis that [6]-gingerol and lafutidine interact with capsaicin-sensitive neurons. Addition of 30 and 100 microM [6]-gingerol (a pungent constituent of ginger) induced contraction of the ileum immediately. Like capsaicin, [6]-gingerol-induced contraction was in...

journal_title：Journal of pharmacological sciences

authors： Someya A,Horie S,Yamamoto H,Murayama T

更新日期：2003-08-01 00:00:00

abstract：:N-methyl-N-nitrosourea (MNU) is widely used to study the mechanism of retinal degenerative diseases (RDs) because of its selectivity of photoreceptor cell death. Many reports suggest that excessive nitric oxide (NO) plays a crucial role in neuronal cell death. We hypothesized that nitric oxide synthase (NOS)/NO are in...

journal_title：Journal of pharmacological sciences

authors： Koriyama Y,Hisano S,Ogai K,Sugitani K,Furukawa A,Kato S

更新日期：2015-03-01 00:00:00

abstract：:The G protein-coupled receptors (GPCRs) form the largest and the most versatile superfamily that share a seven-transmembrane-spanning architecture. GPCR-signaling is involved in vision, taste, olfaction, sympathetic/parasympathetic nervous functions, metabolism, and immune regulation, indicating that GPCRs are extreme...

journal_title：Journal of pharmacological sciences

authors： Miyano K,Sudo Y,Yokoyama A,Hisaoka-Nakashima K,Morioka N,Takebayashi M,Nakata Y,Higami Y,Uezono Y

更新日期：2014-01-01 00:00:00

abstract：:Pantetheinase is an enzyme hydrolyzing pantetheine, an intermediate of the coenzyme A degradation pathway. Pantetheinase has long been considered as the enzyme that recycles pantothenic acid (vitamin B5) generated during coenzyme A breakdown. Genetic analyses showed that mammals have multiple genes known as vanin fami...

journal_title：Journal of pharmacological sciences

authors： Nitto T,Onodera K

更新日期：2013-09-20 00:00:00

abstract：:The roles played by K+ channels in the urothelium (UE) and detrusor smooth muscle (DSM) in regulating agonist-induced bladder contraction is not known at present. Thus, the effects in carbachol (CCh)-induced contraction in UE-intact (+UE) and UE-denuded (-UE) rat detrusor strips pretreated with K+-channel blockers wer...

journal_title：Journal of pharmacological sciences

authors： Hidayat Santoso AG,Liang W

更新日期：2011-01-01 00:00:00

abstract：:Protective effect of valsartan (Val), an angiotensin II (AII)-receptor blocker (ARB), against organ damage is reported to depend on the dosing time in hypertensive patients. Dosing-time-dependent effect of Val on survival of stroke-prone spontaneously hypertensive rats (SHRSP) under a 12-h lighting cycle was examined....

journal_title：Journal of pharmacological sciences

authors： Liu Y,Ushijima K,Ohmori M,Takada M,Tateishi M,Ando H,Fujimura A

更新日期：2011-01-01 00:00:00

abstract：:Stiffness and cytokine in blood levels show 24-h rhythms in rheumatoid arthritis (RA) patients. We previously revealed that higher therapeutic effects were obtained in RA patients and RA model animals when the dosing time of methotrexate was chosen according to the 24-h rhythms to cytokine. In this study, we examined ...

journal_title：Journal of pharmacological sciences

authors： Obayashi K,Tomonari M,Yoshimatsu H,Fukuyama R,Ieiri I,Higuchi S,To H

更新日期：2011-01-01 00:00:00

abstract：:The aim of the present study is to clarify the mechanism for the decrease in intraocular pressure by 2-alkynyladenosine derivatives in rabbits. The receptor binding analysis revealed that 2-(1-octyn-1-yl)adenosine (2-O-Ado) and 2-(6-cyano-1-hexyn-1-yl)adenosine (2-CN-Ado) selectively bound to the A(2a) receptor with a...

journal_title：Journal of pharmacological sciences

authors： Konno T,Murakami A,Uchibori T,Nagai A,Kogi K,Nakahata N

更新日期：2005-04-01 00:00:00

abstract：:Platelet activation is the primary cause of thrombosis. The P2X7 receptor (P2X7R) is a therapeutic target of thrombosis. However, it is still unknown whether P2X7R activation affects platelet thrombus. Our molecular docking results showed that entecavir as a P2X7R antagonist interacted perfectly with the human P2X7R (...

journal_title：Journal of pharmacological sciences

authors： Ming Y,Xin G,Ji B,Ji C,Wei Z,Zhang B,Zhang J,Yu K,Zhang X,Li S,Li Y,Xing Z,Niu H,Huang W

更新日期：2020-09-01 00:00:00

abstract：:The hippocampus is a brain region well-known to exhibit structural and functional changes in temporal lobe epilepsy. Studies analyzing the brains of patients with epilepsy and those from animal models of epilepsy have revealed that microglia are excessively activated, especially in the hippocampus. These findings sugg...

journal_title：Journal of pharmacological sciences

authors： Andoh M,Ikegaya Y,Koyama R

更新日期：2020-12-01 00:00:00

abstract：:We recently developed a novel cognitive enhancer, ST101 (spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one), that activates T-type voltage-gated calcium channels (VGCCs). Here, we address whether T-type VGCC activation with ST101 mediates its cognitive effects in vivo and the relevance of T-type VGCC activation to ace...

journal_title：Journal of pharmacological sciences

authors： Yamamoto Y,Shioda N,Han F,Moriguchi S,Fukunaga K

更新日期：2013-01-01 00:00:00