Abstract:
:Pantetheinase is an enzyme hydrolyzing pantetheine, an intermediate of the coenzyme A degradation pathway. Pantetheinase has long been considered as the enzyme that recycles pantothenic acid (vitamin B5) generated during coenzyme A breakdown. Genetic analyses showed that mammals have multiple genes known as vanin family genes. Recent studies using mice lacking the vanin-1 gene (pantetheinase gene) suggest that pantetheinase is actively involved in the progression of inflammatory reactions by generating cysteamine. Additional studies using human leukocytes demonstrate that human neutrophils have abundant pantetheinase proteins on the surface and inside the cells. The second pantetheinase protein, GPI-80/VNN2, is suggested to work as a modulator of the function of Mac-1 (CD11b/CD18), an adhesion molecule important to neutrophil functions. This review delineates the characteristics of the pantetheinase/vanin gene family and how they affect inflammation.
journal_name
J Pharmacol Scijournal_title
Journal of pharmacological sciencesauthors
Nitto T,Onodera Kdoi
10.1254/jphs.13r01cpsubject
Has Abstractpub_date
2013-09-20 00:00:00pages
1-8issue
1eissn
1347-8613issn
1347-8648pii
DN/JST.JSTAGE/jphs/13R01CPjournal_volume
123pub_type
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