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The antipsychotic and antiemetic drug prochlorperazine delays the ventricular repolarization of the in situ canine heart.

Abstract：

:Electropharmacological effect of the antipsychotic and antiemetic drug prochlorperazine was assessed using the halothane-anesthetized in vivo canine model (n = 5). Up to 10 times higher than the clinically relevant doses of prochlorperazine (< or = 3 mg/kg, i.v.) did not induce cardiohemodynamic collapse in the model. Meanwhile, clinically relevant to supratherapeutic doses (0.3 - 3 mg/kg, i.v.) prolonged the ventricular repolarization period in a dose-related and reverse-use dependent manner that could become proarrhythmic substrates. Thus, caution has to be paid on the use of prochlorperazine particularly for patients with risks of the elevated plasma drug concentration, compromised cardiac repolarization, and/or frequent ventricular premature beats.

journal_name

J Pharmacol Sci

journal_title

Journal of pharmacological sciences

authors

Satoh Y,Sugiyama A,Takahara A,Ando K,Wang K,Honsho S,Hashimoto K

doi

10.1254/jphs.fpj04038x

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

101-6

issue

1

eissn

1347-8613

issn

1347-8648

pii

JST.JSTAGE/jphs/FPJ04038X

journal_volume

97

pub_type

杂志文章

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