Pharmacology in health foods: effects of arachidonic acid and docosahexaenoic acid on the age-related decline in brain and cardiovascular system function.

abstract：:Cisplatin causes chronic interstitial disease with fibrosis, but the development mechanism of interstitial fibrosis is not yet understood. We examined the effect of an antioxidant, N,N'-diphenyl-1,4-phenylenediamine (DPPD), on development of interstitial fibrosis induced by cisplatin. Cisplatin increased blood urea ni...

journal_title：Journal of pharmacological sciences

authors： Kawai Y,Satoh T,Hibi D,Ohno Y,Kohda Y,Miura K,Gemba M

更新日期：2009-12-01 00:00:00

abstract：:The extracellular L-glutamate (L-Glu) concentration is elevated in neuroinflammation, thereby causing excitotoxicity. One of the mechanisms is down-regulation of astrocyte L-Glu transporters. Some antidepressants have anti-inflammatory effects. We therefore investigated effects of various antidepressants on the down-r...

journal_title：Journal of pharmacological sciences

authors： Fujimori K,Takaki J,Shigemoto-Mogami Y,Sekino Y,Suzuki T,Sato K

更新日期：2015-01-01 00:00:00

abstract：:Prolonged QT interval is an independent risk factor for development of ventricular arrhythmias. Haloperidol is one of the drugs inducing QT prolongation. Previous studies showed that haloperidol affects not only QT duration but also heart rate (RR interval). The present work focused on relationship between QT and RR a...

journal_title：Journal of pharmacological sciences

authors： Vesely P,Stracina T,Hlavacova M,Halamek J,Kolarova J,Olejnickova V,Mrkvicova V,Paulova H,Novakova M

更新日期：2019-01-01 00:00:00

abstract：:Paclitaxel, an anticancer drug, frequently causes painful peripheral neuropathy. In this study, we investigated the preventive effect of polaprezinc on paclitaxel-induced peripheral neuropathy in rats. Polaprezinc (3 mg/kg, p.o., once daily) inhibited the development of mechanical allodynia induced by paclitaxel (4 mg...

journal_title：Journal of pharmacological sciences

authors： Tsutsumi K,Kaname T,Shiraishi H,Kawashiri T,Egashira N

更新日期：2016-06-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is defined as elevation of mean pulmonary arterial pressure to ≥25 mmHg within the low pressure pulmonary circulatory system. PAH is characterized by obstructive vascular remodeling, partially due to excessive pulmonary arterial smooth muscle cell (PASMC) proliferation. Puerarin i...

journal_title：Journal of pharmacological sciences

authors： Zhang X,Liu Q,Zhang C,Sheng J,Li S,Li W,Yang X,Wang X,He S,Bai J,Zhu D

更新日期：2019-10-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a group of small noncoding RNAs that regulate translational repression of multiple target mRNAs. The miRNAs in a whole cell regulate greater than 30% of all protein-coding genes. The vast majority of presently identified miRNAs are expressed in the brain in a spatially and temporally controlled ...

journal_title：Journal of pharmacological sciences

authors： Satoh J

更新日期：2010-01-01 00:00:00

abstract：:The purpose of this study was to determine whether carteolol eye drops, a β-adrenoceptor antagonist used as an intraocular hypotensive agent, has protective effects against the light-induced oxidative stress in retina. Dark-adapted pigmented rats were pre-treated with topical carteolol ophthalmic solution or saline an...

journal_title：Journal of pharmacological sciences

authors： Matsuo M,Kuse Y,Takahashi K,Kuwahara K,Tanito M,Kaidzu S,Shimazawa M,Hara H,Ohira A

更新日期：2019-02-01 00:00:00

abstract：:The aim of this study was to characterize the effects of rebamipide on the oxidative burst of human neutrophils. The neutrophil oxidative burst was measured in the presence of rebamipide and cimetidine using lucigenin- or luminol-dependent chemiluminescence (LgCL or LmCL). Rebamipide inhibited the LmCL response stimul...

journal_title：Journal of pharmacological sciences

authors： Shimoyama T,Fukuda S,Liu Q,Fukuda Y,Nakaji S,Sugawara K

更新日期：2003-02-01 00:00:00

abstract：:Androgen-independent prostate cancer (PCa) is a developed tumor derived from the local androgen dependent PCa, which often affects elderly men. Psoralea corylifolia L, a traditional Chinese medicine, has been widely used for PCa treatment as an important part of a common prescription, while the mechanism remains uncle...

journal_title：Journal of pharmacological sciences

authors： Miao L,Yun X,Tao R,Wang Y,Fan G,Zhu Y,Cai T,Zhu Z,Yan C,Gao X

更新日期：2018-09-01 00:00:00

abstract：:To elucidate the mechanism of action of prostaglandin I(2) (PGI(2)) and carbaprostacyclin, we studied their effect on DNA synthesis and proliferation in primary cultures of adult rat hepatocytes. Hepatocyte parenchymal cells, maintained in a serum-free, defined medium, synthesized DNA and proliferated in the presence ...

journal_title：Journal of pharmacological sciences

authors： Kimura M,Okamoto H,Natsume H,Ogihara M

更新日期：2009-04-01 00:00:00

abstract：:This study investigated the effects of thiol and heme oxidants on responsiveness to cGMP generators in isolated rat aorta and pulmonary artery using an organ chamber. The nitric oxide (NO) donor sodium nitroprusside (SNP)-induced relaxation was impaired by exposure to the thiol oxidant diamide in both the aorta and th...

journal_title：Journal of pharmacological sciences

authors： Tawa M,Yamashita Y,Masuoka T,Nakano K,Yoshida J,Nishio M,Ishibashi T

更新日期：2019-05-01 00:00:00

abstract：:The sodium-glucose cotransporter (SGLT) 2 offer a novel approach to treating type 2 diabetes by reducing hyperglycaemia via increased urinary glucose excretion. In the present study, the pharmacokinetic, pharmacodynamic, and pharmacologic properties of all six SGLT2 inhibitors commercially available in Japan were inve...

journal_title：Journal of pharmacological sciences

authors： Tahara A,Takasu T,Yokono M,Imamura M,Kurosaki E

更新日期：2016-03-01 00:00:00

abstract：:A simple in vivo closed-chest atrial fibrillation (Af) model of rats was developed. Af was reproducibly induced by transesophageal atrial burst pacing for 30 s in each of the pentobarbital-anesthetized rats, whereas the cardiohemodynamic condition as well as the inducibility and duration of Af episode was stable over ...

journal_title：Journal of pharmacological sciences

authors： Sugiyama A,Takahara A,Honsho S,Nakamura Y,Hashimoto K

更新日期：2005-07-01 00:00:00

abstract：:Mosapride citrate (mosapride), a prokinetic agent with 5-HT(4)-receptor agonistic activity, is known to enhance gastric emptying and alleviate symptoms in patients with functional dyspepsia (FD). As hyperalgesia and delayed gastric emptying play an important role in the pathogenesis of FD, we used in this study balloo...

journal_title：Journal of pharmacological sciences

authors： Seto Y,Yoshida N,Kaneko H

更新日期：2011-01-01 00:00:00

abstract：:Ischemia/reperfusion (I/R)-induced oxidative stress is a serious clinical problem in the reperfusion therapy for ischemic diseases. Tumstatin is an endogenous bioactive peptide cleaved from type IV collagen α3 chain. We previously reported that T3 peptide, an active subfragment of tumstatin, exerts cytoprotective effe...

journal_title：Journal of pharmacological sciences

authors： Yasuda J,Okada M,Yamawaki H

更新日期：2019-03-01 00:00:00

abstract：:To ascertain whether steroid therapy evokes dentin hypersensitivity (DH)-like tooth pain, we performed a study based on compelling evidence from patients receiving steroid therapy. An exploratory study was conducted using a questionnaire for 220 patients prescribed steroids who attended the Department of Hematology an...

journal_title：Journal of pharmacological sciences

authors： Shoji N,Endo Y,Iikubo M,Ishii T,Harigae H,Aida J,Sakamoto M,Sasano T

更新日期：2016-11-01 00:00:00

abstract：:Secretory diarrhea is one of the most common causes of death world-wide especially in children under 5 years old. Isoliquiritigenin (ISLQ), a plant-derived chalcone, has previously been shown to exert anti-secretory action in vitro and in vivo by inhibiting CFTR Cl- channels. However, its CFTR inhibition potency is co...

journal_title：Journal of pharmacological sciences

authors： Yibcharoenporn C,Chusuth P,Jakakul C,Rungrotmongkol T,Chavasiri W,Muanprasat C

更新日期：2019-07-01 00:00:00

abstract：:Although insulin-resistant states have been associated with endothelial dysfunction due to increased vascular oxidative stress, the underlying mechanisms are pooly understood. Recent experimental evidence suggests that tetrahydrobiopterin (BH(4)), the natural and essential cofactor of NO synthases (NOS), plays a cruci...

journal_title：Journal of pharmacological sciences

authors： Shinozaki K,Kashiwagi A,Masada M,Okamura T

更新日期：2003-03-01 00:00:00

abstract：:We investigated the effects of treatment with trimethyltin (TMT) on the expression of glutathione-related enzymes in mouse hippocampus. TMT promoted the expression of glutathione S-transferase (GST) Ya/Yc mRNA, and GSTA2 protein, but not that of glutamate-cysteine ligase catalytic subunit mRNA, 1 day after injection. ...

journal_title：Journal of pharmacological sciences

authors： Nagashima R,Sano S,Huong NQ,Shiba T,Ogita K

更新日期：2010-01-01 00:00:00

abstract：:Chotosan (CTS), a traditional herbal formula called Kampo medicine, was shown to be effective in the treatment of vascular dementia in a clinical study, and exerted protective effects against transient cerebral ischemia-induced cognitive impairment in mice. In the present study, we investigated the neuroprotective eff...

journal_title：Journal of pharmacological sciences

authors： Sasaki-Hamada S,Suzuki A,Sanai E,Matsumoto K,Oka JI

更新日期：2017-11-01 00:00:00

abstract：:We previously reported that nicotine (NIC)-induced analgesia was elicited in part by activation of the endogenous opioid system. Moreover, it is well known that NIC has physical-dependence liability, but its mechanism is unclear. Therefore, we examined whether physical dependence on NIC was mediated by activation of t...

journal_title：Journal of pharmacological sciences

authors： Ueno K,Kiguchi N,Kobayashi Y,Saika F,Wakida N,Yamamoto C,Maeda T,Ozaki M,Kishioka S

更新日期：2014-01-01 00:00:00

abstract：:We have reported that the differentiation-inducing factors (DIFs) DIF-1 and DIF-3, morphogens secreted from Dictyostelium discoideum, inhibit proliferation of several cancer cells via suppression of the Wnt/beta-catenin signaling pathway. However, the target molecules of DIFs involved in the anti-proliferative effects...

journal_title：Journal of pharmacological sciences

authors： Matsuda T,Takahashi-Yanaga F,Yoshihara T,Maenaka K,Watanabe Y,Miwa Y,Morimoto S,Kubohara Y,Hirata M,Sasaguri T

更新日期：2010-01-01 00:00:00

abstract：:Kv1.5 is considered to be a potential molecular target for treatment of atrial fibrillation or flutter. Disopyramide is widely used in the treatment of atrial flutter and/or atrial fibrillation. The present study was undertaken to characterize the effects of disopyramide on currents mediated by Kv1.5 channels and to d...

journal_title：Journal of pharmacological sciences

authors： Aréchiga IA,Barrio-Echavarria GF,Rodríguez-Menchaca AA,Moreno-Galindo EG,Decher N,Tristani-Firouzi M,Sánchez-Chapula JA,Navarro-Polanco RA

更新日期：2008-09-01 00:00:00

abstract：:L-Dihydroxyphenylalanine (L-DOPA) is considered the gold standard for the treatment of Parkinson's disease (PD). However, long-term administration of L-DOPA can induce abnormal side effects. On the other hand, selective serotonin reuptake inhibitors (SSRIs) including fluoxetine have gained tremendous popularity in the...

journal_title：Journal of pharmacological sciences

authors： Inden M,Abe M,Minamino H,Takata K,Yoshimoto K,Tooyama I,Kitamura Y

更新日期：2012-01-01 00:00:00

abstract：:MMP-9 or Gelatinase B, a member of the matrix metalloproteinase family (MMPs), plays important roles in physiological events such as tissue remodeling and in pathological processes that lead to destructive bone diseases, including osteoarthritis and periodontitis. In addition to its effect on the increase of total bon...

journal_title：Journal of pharmacological sciences

authors： Thunyakitpisal PD,Chaisuparat R

更新日期：2004-04-01 00:00:00

abstract：:We compared dilator actions of representative four Ca2+ channel blockers on the isolated lower esophagus sphincter (LES) and thoracic aorta from rats. Verapamil, diltiazem, nifedipine and cilnidipine suppressed KCl-induced contractions of LES and thoracic aorta in a concentration-dependent manner. The order of selecti...

journal_title：Journal of pharmacological sciences

authors： Takahara A,Nozaki S,Ishiguro A,Okamura K,Cao X,Aimoto M,Nagasawa Y

更新日期：2018-05-01 00:00:00

abstract：:Overexpression of constitutively active (CA)-G alpha13 significantly increased the expression of interleukin (IL)-1beta and IL-6 mRNAs and proteins in rat cardiac fibroblasts. IL-1beta mRNA induction by CA-G alpha13 was suppressed by diphenyleneiodonium (DPI), an NADPH oxidase inhibitor, but not by BAPTA-AM, an intrac...

journal_title：Journal of pharmacological sciences

authors： Nagamatsu Y,Nishida M,Onohara N,Fukutomi M,Maruyama Y,Kobayashi H,Sato Y,Kurose H

更新日期：2006-06-01 00:00:00

abstract：:Fullerene (C(60)), a condensed ring aromatic compound with extended pi systems, is a novel carbon allotrope. Because of its poor solubility in polar solvents, investigation of the biological and pharmacological properties of fullerene has been difficult. Recently, water-soluble fullerene derivatives have been synthesi...

journal_title：Journal of pharmacological sciences

authors： Satoh M,Takayanagi I

更新日期：2006-01-01 00:00:00

abstract：:The role of the Na+ current in the automaticity of the pulmonary vein myocardium was examined in isolated guinea pig pulmonary vein cardiomyocytes and tissue preparations. Tetrodotoxin inhibited the automaticity of pulmonary vein tissue preparations by suppressing the diastolic depolarization of the action potential. ...

journal_title：Journal of pharmacological sciences

authors： Irie M,Hiiro H,Hamaguchi S,Namekata I,Tanaka H

更新日期：2019-09-01 00:00:00

abstract：:Glutamate excitotoxicity mediated by N-methyl-d-aspartate (NMDA) receptors is an important cause of retinal ganglion cell death in glaucoma. To elucidate whether apelin protects against retinal neuronal cell death, we examined protective effects of exogenous and endogenous apelin on neuronal cell death induced by intr...

journal_title：Journal of pharmacological sciences

authors： Ishimaru Y,Sumino A,Kajioka D,Shibagaki F,Yamamuro A,Yoshioka Y,Maeda S

更新日期：2017-01-01 00:00:00