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Microglia modulate the structure and function of the hippocampus after early-life seizures.

Abstract：

:The hippocampus is a brain region well-known to exhibit structural and functional changes in temporal lobe epilepsy. Studies analyzing the brains of patients with epilepsy and those from animal models of epilepsy have revealed that microglia are excessively activated, especially in the hippocampus. These findings suggest that microglia may contribute to the onset and aggravation of epilepsy; however, direct evidence for microglial involvement or the underlying mechanisms by which this occurs remain to be fully discovered. To date, neuron-microglia interactions have been vigorously studied in adult epilepsy models; such studies have clarified microglial responses to excessive synchronous firing of neurons. In contrast, the role of microglia in the postnatal brain of patients with epileptic seizures remain largely unclear. Some early-life seizures, such as complex febrile seizures, have been shown to cause structural and functional changes in the brain, which is a risk factor for future development of epilepsy. Because brain structure and function are actively modulated by microglia in both health and disease, it is essential to clarify the role of microglia in early-life seizures and its impact on epileptogenesis.

journal_name

J Pharmacol Sci

journal_title

Journal of pharmacological sciences

authors

Andoh M,Ikegaya Y,Koyama R

doi

10.1016/j.jphs.2020.09.003

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

212-217

issue

4

eissn

1347-8613

issn

1347-8648

pii

S1347-8613(20)30093-1

journal_volume

144

pub_type

杂志文章,评审

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