Combination effects of ZSET1446/ST101 with memantine on cognitive function and extracellular acetylcholine in the hippocampus.

abstract：:Cytochrome P450 (CYP)-mediated drug interactions caused by Kampo medicine have not been investigated sufficiently. The current study was conducted to reveal the effect of anchusan, a commonly used Kampo formula for gastrointestinal disease, on CYP3A-mediated drug metabolism in rats. The pharmacokinetics of midazolam (...

journal_title：Journal of pharmacological sciences

authors： Saito Y,Nishimura Y,Kurata N,Iwase M,Aoki K,Yasuhara H

更新日期：2011-01-01 00:00:00

abstract：:The biological basis for the therapeutic mechanisms of depression are still unknown. While performing EST (expressed sequence tag) analysis to identify some molecular machinery responsible for the antidepressant effect, we determined the full-length nucleotide sequence of rat frizzled-3 protein (Frz3) cDNA. Interestin...

journal_title：Journal of pharmacological sciences

authors： Yamada M,Iwabuchi T,Takahashi K,Kurahashi C,Ohata H,Honda K,Higuchi T,Yamada M

更新日期：2005-11-01 00:00:00

abstract：:Angiotensin II plays an important role in regulating blood pressure. Moreover, angiotensin II directly promotes organ damage by inducing expression of various genes, such as transforming growth factor (TGF)-β and matrix metalloproteinase (MMP)-9 precursors. Blockade of angiotensin II has been shown to not only lower b...

journal_title：Journal of pharmacological sciences

authors： Takai S,Jin D,Miyazaki M

更新日期：2012-01-01 00:00:00

abstract：:The cell signaling cascades provoked by Wnt proteins (the Wnt signaling pathways), which are well conserved through evolution, play crucial roles to maintain homeostasis of a variety of tissues such as skin, blood, intestine, and brain, as well as to regulate proliferation, morphology, motility, and fate of cells duri...

journal_title：Journal of pharmacological sciences

authors： Takahashi-Yanaga F,Sasaguri T

更新日期：2007-08-01 00:00:00

abstract：:Oleoylethanolamine (OEA), an endogenous high-affinity agonist of peroxisome proliferator-activated receptor alpha (PPAR-α), has revealed the pharmacological properties in the treatment of obesity, atherosclerosis and other diseases through the modulation of lipid metabolism. To assess whether OEA can also regulate non...

journal_title：Journal of pharmacological sciences

authors： Li L,Li L,Chen L,Lin X,Xu Y,Ren J,Fu J,Qiu Y

更新日期：2015-03-01 00:00:00

abstract：:Intestinal Cl- secretion is involved in the pathogenesis of secretory diarrheas including cholera. We recently demonstrated that flufenamic acid (FFA) suppressed Vibrio cholerae El Tor variant-induced intestinal fluid secretion via mechanisms involving AMPK activation and NF-κB-suppression. The present study aimed to ...

journal_title：Journal of pharmacological sciences

authors： Pongkorpsakol P,Yimnual C,Chatsudthipong V,Rukachaisirikul V,Muanprasat C

更新日期：2017-06-01 00:00:00

abstract：:In the present study, we investigated whether a novel benzopyranylindol analogue, KR-31466 (KR466) (1-[(2S,3R,4S)-3,4-dihydro-2-dimethoxymethyl-3-hydroxy-2-methyl-6-nitro-2H-1-benzopyran-4-yl]-1H-indole-2-carboxylic acid ethyl ester) can attenuate hypoxic injury in heart-derived H9c2 cells and, if so, whether the prot...

journal_title：Journal of pharmacological sciences

authors： Jung YS,Jung YS,Kim MY,Kim MH,Lee S,Yi KY,Yoo SE,Lee SH,Baik EJ,Moon CH,Cho JP

更新日期：2003-05-01 00:00:00

abstract：:We investigated the effects of gabapentin and pregabalin on the itch-associated response in a mouse model of chronic dermatitis induced by the repeated application of 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one (oxazolone). Challenging the mice with oxazolone-induced chronic dermatitis with the oxazolone evoked severe...

journal_title：Journal of pharmacological sciences

authors： Tsukumo Y,Matsumoto Y,Miura H,Yano H,Manabe H

更新日期：2011-01-01 00:00:00

abstract：:Neurosteroids are known as allosteric modulators of the ligand-gated ion channel superfamily. Voltage-gated sodium channels (Na(v)) play an important role in mediating excitotoxic damages. Here we report the effects of neurosteroids on the function of Na(v), using voltage-clamp techniques in Xenopus oocytes expressed ...

journal_title：Journal of pharmacological sciences

authors： Horishita T,Ueno S,Yanagihara N,Sudo Y,Uezono Y,Okura D,Sata T

更新日期：2012-01-01 00:00:00

abstract：:The aim of this study was to compare the effect of antimuscarinic antagonists on carbachol-induced contraction of normal human bladder and detrusor overactivity associated with benign prostatic hyperplasia (DO/BPH). Samples of human bladder muscle were obtained from patients undergoing total cystectomy for bladder can...

journal_title：Journal of pharmacological sciences

authors： Yamanishi T,Kaga K,Fuse M,Shibata C,Kamai T,Uchiyama T

更新日期：2015-06-01 00:00:00

abstract：:Hypoxia or hypoxia/reoxygenation impairs nitric oxide (NO)-mediated relaxation through the increase in superoxide generation in monkey coronary arteries. Soluble guanylate cyclase (sGC), the target enzyme of NO, has been shown to change from the NO-sensitive reduced form to the NO-insensitive oxidized/heme-free form u...

journal_title：Journal of pharmacological sciences

authors： Tawa M,Geddawy A,Shimosato T,Iwasaki H,Imamura T,Okamura T

更新日期：2014-01-01 00:00:00

abstract：:Our recent study showed a possibility that newly developed A2 type botulinum toxin (A2NTX) inhibits both spontaneous and evoked transmitter release from inhibitory (glycinergic or GABAergic) and excitatory (glutamatergic) nerve terminals using rat spinal sacral dorsal commissural nucleus neurons. In the present study,...

journal_title：Journal of pharmacological sciences

authors： Yamaga T,Aou S,Shin MC,Wakita M,Akaike N

更新日期：2012-01-01 00:00:00

abstract：:The distribution of group I metabotropic glutamate receptors in rat hippocampal cells in culture was examined by calcium imaging and immunocytochemistry. To distinguish different cell types in the culture, the effects of t-ACPD ((1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid) and of NMDA (N-methyl-D-aspartate) were...

journal_title：Journal of pharmacological sciences

authors： Yoshida Y,Matsumoto N,Tsuchiya R,Morita M,Miyakawa H,Kudo Y

更新日期：2003-07-01 00:00:00

abstract：:The purpose of this study is to identify transient receptor potential canonical (TRPC) channels responsible for receptor-operated Ca(2+) entry (ROCE) triggered by activation of endothelin type A receptor (ET(A)R) and to clarify the importance of calmodulin (CaM) / inositol 1,4,5-trisphosphate (IP(3)) receptor binding ...

journal_title：Journal of pharmacological sciences

authors： Horinouchi T,Terada K,Higa T,Aoyagi H,Nishiya T,Suzuki H,Miwa S

更新日期：2011-01-01 00:00:00

abstract：:Recent epidemiological studies have demonstrated that coffee drinking is associated with reduced mortality of cardiovascular disease. However, its precise mechanisms remain to be clarified. In this study, we examined whether single ingestion of caffeine contained in a cup of coffee improves microvascular function in h...

journal_title：Journal of pharmacological sciences

authors： Noguchi K,Matsuzaki T,Sakanashi M,Hamadate N,Uchida T,Kina-Tanada M,Kubota H,Nakasone J,Sakanashi M,Ueda S,Masuzaki H,Ishiuchi S,Ohya Y,Tsutsui M

更新日期：2015-02-01 00:00:00

abstract：:Although insulin-resistant states have been associated with endothelial dysfunction due to increased vascular oxidative stress, the underlying mechanisms are pooly understood. Recent experimental evidence suggests that tetrahydrobiopterin (BH(4)), the natural and essential cofactor of NO synthases (NOS), plays a cruci...

journal_title：Journal of pharmacological sciences

authors： Shinozaki K,Kashiwagi A,Masada M,Okamura T

更新日期：2003-03-01 00:00:00

abstract：:Opioid analgesics are widely used for the treatment of moderate to severe pain. The analgesic effects of opioids are well known to vary among individuals. The present study focused on the genetic factors that are associated with interindividual differences in pain and opioid sensitivity. We conducted a multistage geno...

journal_title：Journal of pharmacological sciences

authors： Takahashi K,Nishizawa D,Kasai S,Koukita Y,Fukuda KI,Ichinohe T,Ikeda K

更新日期：2018-03-01 00:00:00

abstract：:Yeasts isolated from patients with superficial mycoses were tested against propolis samples collected from different regions and honeybee races. The minimum inhibitory concentration (MIC) values obtained using the agar dilution methods were compared to the diameters of growth inhibition zones by using the disk diffusi...

journal_title：Journal of pharmacological sciences

authors： Silici S,Koç NA,Ayangil D,Cankaya S

更新日期：2005-09-01 00:00:00

abstract：:Peripheral-type benzodiazepine receptor (PBR) and central-type benzodiazepine receptor (CBR) in salivary gland play a role in the inhibitory regulation of salivary secretion in rodents. Diazepam-binding inhibitor (DBI), an endogenous ligand for PBR, produces neurosteroids, which modulate CBR activity. In this study, w...

journal_title：Journal of pharmacological sciences

authors： Tsukagoshi E,Kawaguchi M,Shinomiya T,Yoshikawa M,Kawano T,Okubo M,Sawaki K

更新日期：2011-01-01 00:00:00

abstract：:G protein-coupled receptors, in particular, Ca(2+)-mobilizing G(q)-coupled receptors have been reported to be targets for anesthetics. Opioids are commonly used analgesics in clinical practice, but the effects of anesthetics on the opioid mu-receptors (muOR) have not been systematically examined. We report here an ele...

journal_title：Journal of pharmacological sciences

authors： Minami K,Sudo Y,Shiraishi S,Seo M,Uezono Y

更新日期：2010-01-01 00:00:00

abstract：:Acid-sensing ion channels (ASICs) are proton-sensitive sodium channels that open in response to lowered extracellular pH and are expressed in the central and peripheral nervous systems. The ASIC3 subtype is found primarily in the periphery where the channel mediates pain signals caused by ischemia and inflammation. He...

journal_title：Journal of pharmacological sciences

authors： Agharkar AS,Gonzales EB

更新日期：2017-03-01 00:00:00

abstract：:Leptin is an adipose tissue-derived secretory hormone that suppresses appetite by inhibition of neuropepeptide Y (NPY) gene expression in arcuate nucleus (ARC) in the hypothalamus. To investigate the transcriptional regulation of NPY gene by leptin, we carried out a luciferase assay using NPY gene promotor plasmid (NP...

journal_title：Journal of pharmacological sciences

authors： Higuchi H,Hasegawa A,Yamaguchi T

更新日期：2005-07-01 00:00:00

abstract：:In this paper, we investigated interactions of the acidic oligosaccharide sugar chain (AOSC), derived from brown algae Echlonia kurome OKAM, with amyloid beta protein (Abeta). We observed that AOSC inhibited the toxicity induced by Abeta in both primarily cortical cells and the SH-SY5Y cell line. We also observed that...

journal_title：Journal of pharmacological sciences

authors： Hu J,Geng M,Li J,Xin X,Wang J,Tang M,Zhang J,Zhang X,Ding J

更新日期：2004-06-01 00:00:00

abstract：:The extracellular L-glutamate (L-Glu) concentration is elevated in neuroinflammation, thereby causing excitotoxicity. One of the mechanisms is down-regulation of astrocyte L-Glu transporters. Some antidepressants have anti-inflammatory effects. We therefore investigated effects of various antidepressants on the down-r...

journal_title：Journal of pharmacological sciences

authors： Fujimori K,Takaki J,Shigemoto-Mogami Y,Sekino Y,Suzuki T,Sato K

更新日期：2015-01-01 00:00:00

abstract：:Isolation-induced abnormal behaviors are useful animal models for assessing potential anti-psychotic drugs. This study examined the effect of MGS0028, a selective metabotropic glutamate 2/3 receptor agonist, on abnormal behaviors such as hyperactivity, aggression, and deficits of prepulse inhibition in isolation-reare...

journal_title：Journal of pharmacological sciences

authors： Ago Y,Araki R,Yano K,Kawasaki T,Chaki S,Nakazato A,Onoe H,Hashimoto H,Baba A,Takuma K,Matsuda T

更新日期：2012-01-01 00:00:00

abstract：:Cyclophosphamide (CPA) is a widely used chemotherapeutic drug for neoplasias. It is a DNA and protein alkylating agent having a broad spectrum of activity against a variety of neoplasms including breast cancer. The therapeutic effectiveness of CPA is limited by the high-dose hematopoietic, renal, and cardiac toxicity ...

journal_title：Journal of pharmacological sciences

authors： Singh N,Nigam M,Ranjan V,Sharma R,Balapure AK,Rath SK

更新日期：2009-04-01 00:00:00

abstract：:Pancreatic cancer has remained a major cause of cancer-related deaths. A hallmark of pancreatic cancer is extensive stromal reactions, resulting in a unique tumor microenvironment, especially the involvement of macrophages. These tumor-educated cells limit the efficacy of chemotherapy. Therefore, it is necessary to id...

journal_title：Journal of pharmacological sciences

authors： Wang B,Zheng X,Liu J,Zhang Z,Qiu C,Yang L,Zhang L,Zhang Q,Gao H,Wang X

更新日期：2018-07-01 00:00:00

abstract：:Based on the structure of AAP, a novel anti-thrombotic peptide from snake venom which we discovered in our previous study, more than 60 compounds were designed and synthesized. One of these termed as LX0702 exhibited stronger anti-platelet aggregation activity than AAP. This study aims to investigate the effects of LX...

journal_title：Journal of pharmacological sciences

authors： Kong Y,Wang Y,Yang W,Xie Z,Li Z

更新日期：2015-04-01 00:00:00

abstract：:Mosapride citrate (mosapride), a prokinetic agent with 5-HT(4)-receptor agonistic activity, is known to enhance gastric emptying and alleviate symptoms in patients with functional dyspepsia (FD). As hyperalgesia and delayed gastric emptying play an important role in the pathogenesis of FD, we used in this study balloo...

journal_title：Journal of pharmacological sciences

authors： Seto Y,Yoshida N,Kaneko H

更新日期：2011-01-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPARgamma) is a ligand-dependent transcriptional factor implicated in regulating adipogenesis, glucose homeostasis, and in mediating the action of the insulin sensitizing anti-diabetic thiazolidinedione (TZD) compounds. [3-(2,4-Dichlorobenzyl)-2-methyl-N-(pentylsulfony...

journal_title：Journal of pharmacological sciences

authors： Fujimura T,Sakuma H,Konishi S,Oe T,Hosogai N,Kimura C,Aramori I,Mutoh S

更新日期：2005-12-01 00:00:00