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Specific enhancement of vascular endothelial growth factor (VEGF) production in ischemic region by alprostadil--potential therapeutic application in pharmaceutical regenerative medicine.

Abstract：

:Alprostadil (lipo-PGE1) is a drug delivery system preparation. This preparation is applied to treat refractory skin ulcers and arteriosclerosis obliterans. We investigated the effects of alprostadil by using the earflap ischemic model. The following results were obtained: 1) Treatment with alprostadil significantly increased the VEGF contents in an ischemic ear; 2) Treatment with alprostadil resulted in strongly expressed VEGF levels only in the ischemic region; 3) Image analysis revealed a significant increase in the number of vessel bypasses and paths after flap creation with alprostadil administration compared to the vehicle-treated ears. The results suggest that it may be possible to apply alprostadil as one device for regenerative medical technology.

journal_name

J Pharmacol Sci

journal_title

Journal of pharmacological sciences

authors

Inoue H,Aihara M,Tomioka M,Watabe Y

doi

10.1254/jphs.13033sc

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

158-61

issue

2

eissn

1347-8613

issn

1347-8648

pii

DN/JST.JSTAGE/jphs/13033SC

journal_volume

122

pub_type

杂志文章

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