Abstract:
:Microglia are macrophage-like phagocytic cells in the brain parenchyma. However, microglial function after neurodegeneration is not fully understood. In this study, occlusion of the middle cerebral artery (MCA) and reperfusion caused massive neuronal loss in the rat cerebral cortex and striatum after 3 days. When exogenous microglia were microinjected into the intracerebroventricle during MCA occlusion, neurodegenerative areas significantly decreased. At that time, migrated microglia were detected in the ischemic lesion. These results suggest that exogenous microglia can migrate into brain parenchyma and then protect against neurodegeneration induced by MCA occlusion and reperfusion.
journal_name
J Pharmacol Scijournal_title
Journal of pharmacological sciencesauthors
Kitamura Y,Takata K,Inden M,Tsuchiya D,Yanagisawa D,Nakata J,Taniguchi Tdoi
10.1254/jphs.94.203subject
Has Abstractpub_date
2004-02-01 00:00:00pages
203-6issue
2eissn
1347-8613issn
1347-8648journal_volume
94pub_type
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