Abstract:
:Although the opioid system is known to modulate depression-like behaviors, its role in the effects of antidepressants is not yet clear. We investigated the role of μ-opioid receptors (MOPs) in the effects of venlafaxine, a serotonin and norepinephrine reuptake inhibitor, in the forced swim test using MOP-knockout (KO) mice. Venlafaxine reduced immobility time in wild-type mice (C57BL/6J), but not in MOP-KO mice, although no significant effects were observed on locomotor activity. These results suggest that MOPs play an important role in the antidepressant-like effects of venlafaxine.
journal_name
J Pharmacol Scijournal_title
Journal of pharmacological sciencesauthors
Ide S,Fujiwara S,Fujiwara M,Sora I,Ikeda K,Minami M,Uhl GR,Ishihara Kdoi
10.1254/jphs.10136scsubject
Has Abstractpub_date
2010-01-01 00:00:00pages
107-10issue
1eissn
1347-8613issn
1347-8648pii
JST.JSTAGE/jphs/10136SCjournal_volume
114pub_type
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