Abstract:
:The cell signaling cascades provoked by Wnt proteins (the Wnt signaling pathways), which are well conserved through evolution, play crucial roles to maintain homeostasis of a variety of tissues such as skin, blood, intestine, and brain, as well as to regulate proliferation, morphology, motility, and fate of cells during embryonic development. Among these pathways, the signal transduction through beta-catenin (the Wnt/beta-catenin signaling pathway) has been most intensively studied because this signal regulates the expression of a number of genes essential for cell proliferation and differentiation and also this pathway is perturbed in a number of diseases such as cancers, bone diseases, and cardiovascular diseases. However, there is no therapeutic agents that can selectively modulate the Wnt/beta-catenin signaling pathway, although some existing drugs (e.g., non-steroidal anti-inflammatory drugs, vitamins, and imatinib mesylate) have been suggested to inhibit this pathway. Here we provide an overview of the Wnt/beta-catenin signaling pathway: its roles in physiology and pathology and the possibility as a target in development of new drugs.
journal_name
J Pharmacol Scijournal_title
Journal of pharmacological sciencesauthors
Takahashi-Yanaga F,Sasaguri Tdoi
10.1254/jphs.cr0070024subject
Has Abstractpub_date
2007-08-01 00:00:00pages
293-302issue
4eissn
1347-8613issn
1347-8648pii
JST.JSTAGE/jphs/CR0070024journal_volume
104pub_type
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journal_title:Journal of pharmacological sciences
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journal_title:Journal of pharmacological sciences
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journal_title:Journal of pharmacological sciences
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journal_title:Journal of pharmacological sciences
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journal_title:Journal of pharmacological sciences
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更新日期:2005-07-01 00:00:00
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journal_title:Journal of pharmacological sciences
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journal_title:Journal of pharmacological sciences
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更新日期:2006-12-01 00:00:00
abstract::Pseudolaric acid B (PAB) exerted cytostatic activity on murine fibrosarcoma L929 cells. The cytostatic mechanism of PAB on L929 cells was investigated in this paper. At 36 h, after 80 microM PAB treatment, the inhibitory ratio was 65.37 +/- 4.12%, and the MDC staining ratio was strongest in L929 cells. 3-Methyladenine...
journal_title:Journal of pharmacological sciences
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更新日期:2013-01-01 00:00:00
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journal_title:Journal of pharmacological sciences
pub_type: 杂志文章
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更新日期:2009-04-01 00:00:00
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journal_title:Journal of pharmacological sciences
pub_type: 杂志文章
doi:10.1016/j.jphs.2018.02.002
更新日期:2018-03-01 00:00:00
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journal_title:Journal of pharmacological sciences
pub_type: 杂志文章,评审
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更新日期:2019-08-01 00:00:00
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journal_title:Journal of pharmacological sciences
pub_type: 杂志文章
doi:10.1254/jphs.11181fp
更新日期:2012-01-01 00:00:00
abstract::Kursi Wufarikun Ziyabit (KWZ) is a traditional prescription that used in folk tea drinking for its health care effect in treatment of type 2 diabetes mellitus (T2DM) in central Asia. However, the underlying mechanism of KWZ in T2DM has not been investigated extensively. This study designed to observe the effect of KWZ...
journal_title:Journal of pharmacological sciences
pub_type: 杂志文章
doi:10.1016/j.jphs.2018.06.011
更新日期:2018-06-01 00:00:00
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journal_title:Journal of pharmacological sciences
pub_type: 杂志文章
doi:10.1016/j.jphs.2016.02.003
更新日期:2016-03-01 00:00:00
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journal_title:Journal of pharmacological sciences
pub_type: 杂志文章
doi:10.1016/j.jphs.2018.11.010
更新日期:2019-02-01 00:00:00
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journal_title:Journal of pharmacological sciences
pub_type: 杂志文章
doi:10.1016/j.jphs.2019.09.002
更新日期:2019-09-01 00:00:00
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journal_title:Journal of pharmacological sciences
pub_type: 杂志文章,评审
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journal_title:Journal of pharmacological sciences
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更新日期:2010-01-01 00:00:00
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journal_title:Journal of pharmacological sciences
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更新日期:2004-12-01 00:00:00
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journal_title:Journal of pharmacological sciences
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更新日期:2019-05-01 00:00:00
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journal_title:Journal of pharmacological sciences
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更新日期:2005-04-01 00:00:00
abstract::We examined the effects of a cannabinoid receptor agonist, (R)-(+)-[2,3-dihydro-5-methyl-3-[(4-merpholino)methyl]pyrrolo-[1,2,3-de]-1,4-benzoxazin-6-yl](1-naphthyl)methanone (WIN 55212-2), on various respiratory reactions induced by the activation of capsaicin-sensitive afferent sensory nerves (C-fibers). WIN 55212-2 ...
journal_title:Journal of pharmacological sciences
pub_type: 杂志文章
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更新日期:2005-05-01 00:00:00
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journal_title:Journal of pharmacological sciences
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abstract::Baicalin from Scutellaria baicalensis is a major flavonoid constituent found in the traditional Chinese medicinal herb Baikal skull cap. It has been widely used for the treatment of various diseases such as pneumonia, diarrhea, and hepatitis. Recent studies have demonstrated that baicalin possesses a wide range of pha...
journal_title:Journal of pharmacological sciences
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
abstract::Glucocorticoids are stress hormones released from the adrenal cortex and their concentration is controlled by the hypothalamic-pituitary-adrenal axis. In this study, we investigated the effect of glucocorticoids on the number of astrocytes and glucocorticoid receptor (GR) expression in vitro and in vivo. Proliferation...
journal_title:Journal of pharmacological sciences
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journal_title:Journal of pharmacological sciences
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:Journal of pharmacological sciences
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doi:10.1254/jphs.fpj04035x
更新日期:2004-11-01 00:00:00
abstract::We aimed to examine the rate of thrombotic events after discontinuation of one year clopidogrel therapy in patients with implanted coronary stent, and to determine platelet aggregability by multiple electrode analyzer after cessation of clopidogrel. This prospective, multicenter study enrolled 200 patients subjected t...
journal_title:Journal of pharmacological sciences
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doi:10.1254/jphs.11076fp
更新日期:2011-01-01 00:00:00
abstract::The critical role played by the renin-angiotensin-aldosterone system (RAAS) in the regulation of blood pressure and body fluid homeostasis has been well recognized. Angiotensin (Ang) II and aldosterone are the most powerful biologically active products of the RAAS, although there are also other bioactive Ang peptides ...
journal_title:Journal of pharmacological sciences
pub_type: 杂志文章,评审
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更新日期:2010-01-01 00:00:00